scholarly journals Associations between Common Genetic Variants in MicroRNAs and Hirschsprung disease Susceptibility in Southern Chinese Children

2020 ◽  
Author(s):  
Qi Wu ◽  
Jinglu Zhao ◽  
Yi Zheng ◽  
Xiaoli Xie ◽  
Qiuming He ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Disease Susceptibility ◽  
Hirschsprung Disease ◽  
Chinese Children ◽  
Southern Chinese ◽  
Common Genetic Variants

scholarly journals Association of VAMP5 and MCC genetic polymorphisms with increased risk of Hirschsprung disease susceptibility in Southern Chinese children

Aging ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 689-700 ◽  
Author(s):  
Jinglu Zhao ◽  
Xiaoli Xie ◽  
Yuxiao Yao ◽  
Qiuming He ◽  
Ruizhong Zhang ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Disease Susceptibility ◽  
Hirschsprung Disease ◽  
Chinese Children ◽  
Southern Chinese ◽  
Increased Risk

scholarly journals Common genetic variants in pre-microRNAs are associated with cervical cancer susceptibility in southern Chinese women

2020 ◽  
Vol 11 (8) ◽  
pp. 2133-2138 ◽  
Author(s):  
Guange Chen ◽  
Mingyao Zhang ◽  
Jiawei Zhu ◽  
Feng Chen ◽  
Danyang Yu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Genetic Variants ◽  
Cancer Susceptibility ◽  
Chinese Women ◽  
Southern Chinese ◽  
Common Genetic Variants ◽  
Southern Chinese Women

scholarly journals miR-618 rs2682818 C>A polymorphism decreases Hirschsprung disease risk in Chinese children

2020 ◽  
Vol 40 (5) ◽  
Author(s):  
Yi Zheng ◽  
Tongyi Lu ◽  
Xiaoli Xie ◽  
Qiuming He ◽  
Lifeng Lu ◽  
...  
Keyword(s):  
Disease Risk ◽  
Malignant Tumors ◽  
Hirschsprung Disease ◽  
Chinese Children ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Functional Region ◽  
Tumor Susceptibility ◽  
Southern Chinese ◽  
Stratified Analysis

Abstract MicroRNAs (miRNAs) are endogenous non-coding small RNAs that play an important role in the development of many malignant tumors. In addition, recent studies have reported that single nucleotide polymorphisms (SNPs) located in the miRNA functional region was inextricably linked to tumor susceptibility. In the present study, we investigated the susceptibility between miR-618 rs2682818 C>A and Hirschsprung disease (HSCR) in the Southern Chinese population (1470 patients and 1473 controls). Odds ratios (ORs) and 95% confidence intervals (CIs) were used for estimating the strength of interrelation between them. We found that the CA/AA genotypes of miR-618 rs2682818 were associated with a decreased risk of HSCR when compared with the CC genotype (OR = 0.84, 95% CI = 0.72–0.99, P=0.032). Based on the stratified analysis of HSCR subtypes, the rs2682818 CA/AA genotypes were able to significantly lessen the risk of HSCR compared with CC genotype in patients with long-segment HSCR (adjusted OR = 0.70, 95% CI = 0.52–0.93, P=0.013). In conclusion, our results indicated that the miR-618 rs2682818 C>A polymorphism was associated with a reduced risk of HSCR in Chinese children, especially in patients with long-segment HSCR (L-HSCR) subtype.

scholarly journals miR-100 rs1834306 A>G Increases the Risk of Hirschsprung Disease in Southern Chinese Children

2020 ◽  
Vol Volume 13 ◽  
pp. 283-288
Author(s):  
Yun Zhu ◽  
Ao Lin ◽  
Yi Zheng ◽  
Xiaoli Xie ◽  
Qiuming He ◽  
...  
Keyword(s):  
Hirschsprung Disease ◽  
Chinese Children ◽  
Southern Chinese
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