Long non‐coding RNA SNHG6 increases JAK2 expression by targeting the miR‐181 family to promote colorectal cancer cell proliferation

2020 ◽  
Vol 22 (12) ◽  
Author(s):  
Fangfang Lai ◽  
Wei Deng ◽  
Chunhua Fu ◽  
Pengbo Wu ◽  
Mingwei Cao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Colorectal Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Long Non-Coding RNA FLVCR1-AS1 Acts as miR-493-3p Sponge to Modulate Cancer Cell Proliferation, Invasion and Migration in Colorectal Cancer

2020 ◽  
Vol 10 (3) ◽  
pp. 306-314
Author(s):  
Tingyun Cui ◽  
Dechun Gui ◽  
Chao Gu ◽  
Shuai Yan ◽  
Yinzi Yue ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Invasion And Migration ◽  
Non Coding Rna ◽  
Colorectal Cancer Cells ◽  
Colorectal Cancer Cell Lines ◽  
And Migration ◽  
Long Non Coding Rna

This study aimed to investigate the effect and mechanism of long non-coding RNA FLVCR1-AS1 on proliferation, invasion and migration of colorectal cancer. QRT-PCR was used to detect the expression of FLVCR1-AS1 in colorectal cancer. The target genes of FLVCR1-AS1 were predicted using the StarBase and Luciferase assay. The biological function of miR-493-3p through a series of in vitro experiments. We examined the expression of FLVCR1-AS1 in colorectal cancer cell lines was remarkably increased. Interference with FLVCR1-AS1 inhibits proliferation, invasion and migration of colorectal cancer cell lines. MiR-493-3p is a targeted miRNA of lncRNA FLVCR1-AS1, and overexpression of miR-493-3p inhibits proliferation of colorectal cancer cells, invasion and migration of colorectal cancer cells, and it can be reversed by lncRNA FLVCR1-AS1. LncRNA FLVCR1-AS1 acts as miR-493-3p sponge to modulate cancer cell proliferation, invasion and migration in colorectal cancer.

Sign in / Sign up

Export Citation Format

Share Document