MiR‐96‐5p promotes breast cancer migration by activating MEK/ERK signaling

2020 ◽  
Vol 22 (8) ◽  
Author(s):  
Wei‐yan Qin ◽  
Shi‐chun Feng ◽  
Yong‐qiang Sun ◽  
Guo‐qin Jiang
Keyword(s):  
Breast Cancer ◽  
Erk Signaling ◽  
Cancer Migration

Hypoxia/reoxygenation: A dynamic regulator of lysyl oxidase-facilitated breast cancer migration

2008 ◽  
Vol 103 (5) ◽  
pp. 1369-1378 ◽  
Author(s):  
Lynne-Marie Postovit ◽  
Daniel E. Abbott ◽  
Stacey L. Payne ◽  
William W. Wheaton ◽  
Naira V. Margaryan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lysyl Oxidase ◽  
Cancer Migration ◽  
Hypoxia Reoxygenation

scholarly journals Subereamolline A as a Potent Breast Cancer Migration, Invasion and Proliferation Inhibitor and Bioactive Dibrominated Alkaloids from the Red Sea Sponge Pseudoceratina arabica

Marine Drugs ◽  
2012 ◽  
Vol 10 (12) ◽  
pp. 2492-2508 ◽  
Author(s):  
Lamiaa Shaala ◽  
Diaa Youssef ◽  
Mansour Sulaiman ◽  
Fathy Behery ◽  
Ahmed Foudah ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Red Sea ◽  
Cancer Migration

scholarly journals AMPKα1 Regulates Lung and Breast Cancer Progression by Regulating TLR4-Mediated TRAF6-BECN1 Signaling Axis

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3289
Author(s):  
Mi-Jeong Kim ◽  
Yoon Min ◽  
Juhee Son ◽  
Ji Young Kim ◽  
Ji Su Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
A549 Cells ◽  
Migration And Invasion ◽  
Serum Starvation ◽  
Lung Cancers ◽  
Cancer Migration ◽  
Expression Of Genes ◽  
Autophagy Induction ◽  
Signaling Axis

TRAF6-BECN1 signaling axis is critical for autophagy induction and functionally implicated in cancer progression. Here, we report that AMP-activated protein kinase alpha 1 (AMPKα1, PRKAA1) is positively involved in autophagy induction and cancer progression by regulating TRAF6-BECN1 signaling axis. Mechanistically, AMPKα1 interacted with TRAF6 and BECN1. It also enhanced ubiquitination of BECN1 and autophagy induction. AMPKα1-knockout (AMPKα1KO) HEK293T or AMPKα1-knockdown (AMPKα1KD) THP-1 cells showed impaired autophagy induced by serum starvation or TLR4 (Toll-like receptor 4) stimulation. Additionally, AMPKα1KD THP-1 cells showed decreases of autophagy-related and autophagosome-related genes induced by TLR4. AMPKα1KO A549 cells exhibited attenuation of cancer migration and invasion induced by TLR4. Moreover, primary non-small cell lung cancers (NSCLCs, n = 6) with low AMPKαl levels showed markedly decreased expression of genes related to autophagy, cell migration and adhesion/metastasis, inflammation, and TLRs whereas these genes were significantly upregulated in NSCLCs (n = 5) with high AMPKαl levels. Consistently, attenuation of cancer migration and invasion could be observed in AMPKα1KO MDA-MB-231 and AMPKα1KO MCF-7 human breast cancer cells. These results suggest that AMPKα1 plays a pivotal role in cancer progression by regulating the TRAF6-BECN1 signaling axis for autophagy induction.

TRAIL-induced miR-146a expression suppresses CXCR4-mediated human breast cancer migration

FEBS Journal ◽  
2013 ◽  
Vol 280 (14) ◽  
pp. 3340-3353 ◽  
Author(s):  
Dongsheng Wang ◽  
Dan Liu ◽  
Jing Gao ◽  
Min Liu ◽  
Shilian Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Cancer Migration

Mechanical regulation of breast cancer migration and apoptosis via direct and indirect osteocyte signaling

2018 ◽  
Vol 119 (7) ◽  
pp. 5665-5675 ◽  
Author(s):  
Yu‐Heng V. Ma ◽  
Candy Lam ◽  
Shreyash Dalmia ◽  
Peter Gao ◽  
Jacob Young ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Migration ◽  
Mechanical Regulation
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