Non-invasive detection of bladder cancer via expression-targeted gene delivery

2017 ◽  
Vol 19 (11) ◽  
pp. e2992
Author(s):  
Yunlan Fang ◽  
Benjamin Wolfson ◽  
W T. Godbey
Keyword(s):  
Bladder Cancer ◽  
Gene Delivery ◽  
Targeted Gene Delivery ◽  
Non Invasive

Targeted gene delivery to the cardiac tissue by adenovirus conjugated magnetic nanobeads

2011 ◽  
Vol 59 (S 01) ◽  
Author(s):  
Y Zhang ◽  
W Li ◽  
W Wang ◽  
L Ou ◽  
A Liebold ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cardiac Tissue ◽  
Targeted Gene Delivery ◽  
Magnetic Nanobeads

scholarly journals Tropism-Modification Strategies for Targeted Gene Delivery Using Adenoviral Vectors

Viruses ◽  
2010 ◽  
Vol 2 (10) ◽  
pp. 2290-2355 ◽  
Author(s):  
Lynda Coughlan ◽  
Raul Alba ◽  
Alan L. Parker ◽  
Angela C. Bradshaw ◽  
Iain A. McNeish ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Adenoviral Vectors ◽  
Targeted Gene Delivery

Antheraea pernyi silk fibroin for targeted gene delivery of VEGF165-Ang-1 with PEI

2014 ◽  
Vol 9 (3) ◽  
pp. 035015 ◽  
Author(s):  
Caili Ma ◽  
Linlin Lv ◽  
Yu Liu ◽  
Yanni Yu ◽  
Renchuan You ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Silk Fibroin ◽  
Antheraea Pernyi ◽  
Targeted Gene Delivery

Nonenzymatic glycosylation of poly-l-lysine: A new tool for targeted gene delivery

Hepatology ◽  
1994 ◽  
Vol 20 (6) ◽  
pp. 1602-1608 ◽  
Author(s):  
Daniel Martinez-Fong ◽  
Jerald E. Mullersman ◽  
Anthony F. Purchio ◽  
Juan Armendariz-Borunda ◽  
Antonio Martinez-Hernandez M.D.
Keyword(s):  
Gene Delivery ◽  
Nonenzymatic Glycosylation ◽  
Targeted Gene Delivery

PEGylated poly(2-(dimethylamino) ethyl methacrylate)/DNA polyplex micelles decorated with phage-displayed TGN peptide for brain-targeted gene delivery

Biomaterials ◽  
2013 ◽  
Vol 34 (8) ◽  
pp. 2117-2129 ◽  
Author(s):  
Yong Qian ◽  
Yuan Zha ◽  
Bing Feng ◽  
Zhiqing Pang ◽  
Bo Zhang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Targeted Gene Delivery ◽  
Ethyl Methacrylate

scholarly journals Phase I/II and Phase II Studies of Targeted Gene Delivery In Vivo: Intravenous Rexin-G for Chemotherapy-resistant Sarcoma and Osteosarcoma

2009 ◽  
Vol 17 (9) ◽  
pp. 1651-1657 ◽  
Author(s):  
Sant P Chawla ◽  
Victoria S Chua ◽  
Lita Fernandez ◽  
Doris Quon ◽  
Andreh Saralou ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Phase I ◽  
Phase Ii ◽  
Targeted Gene Delivery ◽  
Phase Ii Studies

scholarly journals Epigenomic and Metabolomic Integration Reveals Dynamic Metabolic Regulation in Bladder Cancer

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2719
Author(s):  
Alba Loras ◽  
Cristina Segovia ◽  
José Luis Ruiz-Cerdá
Keyword(s):  
Bladder Cancer ◽  
Cancer Biology ◽  
Metabolic Regulation ◽  
Tumor Development ◽  
Dna Methyltransferases ◽  
Pentose Phosphate ◽  
Metabolic Reprogramming ◽  
Oncogenic Signaling ◽  
Invasive Approach ◽  
Non Invasive

Bladder cancer (BC) represents a clinical, social, and economic challenge due to tumor-intrinsic characteristics, limitations of diagnostic techniques and a lack of personalized treatments. In the last decade, the use of liquid biopsy has grown as a non-invasive approach to characterize tumors. Moreover, the emergence of omics has increased our knowledge of cancer biology and identified critical BC biomarkers. The rewiring between epigenetics and metabolism has been closely linked to tumor phenotype. Chromatin remodelers interact with each other to control gene silencing in BC, but also with stress-inducible factors or oncogenic signaling cascades to regulate metabolic reprogramming towards glycolysis, the pentose phosphate pathway, and lipogenesis. Concurrently, one-carbon metabolism supplies methyl groups to histone and DNA methyltransferases, leading to the hypermethylation and silencing of suppressor genes in BC. Conversely, α-KG and acetyl-CoA enhance the activity of histone demethylases and acetyl transferases, increasing gene expression, while succinate and fumarate have an inhibitory role. This review is the first to analyze the interplay between epigenome, metabolome and cell signaling pathways in BC, and shows how their regulation contributes to tumor development and progression. Moreover, it summarizes non-invasive biomarkers that could be applied in clinical practice to improve diagnosis, monitoring, prognosis and the therapeutic options in BC.

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