Important role of phosphoramido linkage in imidazole-based dioleyl helper lipids for liposome stability and primary cell transfection

2016 ◽  
Vol 18 (1-3) ◽  
pp. 3-15 ◽  
Author(s):  
Mathieu Mével ◽  
Thomas Haudebourg ◽  
Thibault Colombani ◽  
Pauline Peuziat ◽  
Laurence Dallet ◽  
...  
Keyword(s):  
Primary Cell ◽  
Cell Transfection ◽  
Liposome Stability

The role of ER stress for the pathogenesis of SCA3 in primary cell culture experiment

2007 ◽  
Vol 34 (S 2) ◽  
Author(s):  
C Funke ◽  
J Hübener ◽  
H Wolburg ◽  
T Schmidt ◽  
H Toresson ◽  
...  
Keyword(s):  
Cell Culture ◽  
Er Stress ◽  
Primary Cell Culture ◽  
Primary Cell ◽  
Culture Experiment ◽  
Cell Culture Experiment

The role of apolipoprotein- and vitronectin-enriched protein corona on lipid nanoparticles for in vivo targeted delivery and transfection of oligonucleotides in murine tumor models

Nanoscale ◽  
2019 ◽  
Vol 11 (40) ◽  
pp. 18806-18824 ◽  
Author(s):  
Dongyu Chen ◽  
Neha Parayath ◽  
Shanthi Ganesh ◽  
Weimin Wang ◽  
Mansoor Amiji
Keyword(s):  
Targeted Delivery ◽  
Protein Corona ◽  
Lipid Nanoparticles ◽  
Cell Transfection ◽  
Tumor Models ◽  
Profound Impact ◽  
Murine Tumor ◽  
Composition Changes

We demonstrated that protein corona can be altered by lipid nanoparticle composition changes. Protein corona composition differences had a profound impact on cell transfection, in vivo biodistribution and tumor-specific delivery.

scholarly journals The Role of the Primary Cell Wall in Plant Morphogenesis

2018 ◽  
Vol 19 (9) ◽  
pp. 2674 ◽  
Author(s):  
Derek Lamport ◽  
Li Tan ◽  
Michael Held ◽  
Marcia Kieliszewski
Keyword(s):  
Cell Wall ◽  
Plasma Membrane ◽  
Computational Modelling ◽  
Primary Cell ◽  
Arabinogalactan Protein ◽  
Primary Cell Wall ◽  
Proton Pumps ◽  
Plant Morphogenesis ◽  
Evolutionary Origins

Morphogenesis remains a riddle, wrapped in a mystery, inside an enigma. It remains a formidable problem viewed from many different perspectives of morphology, genetics, and computational modelling. We propose a biochemical reductionist approach that shows how both internal and external physical forces contribute to plant morphogenesis via mechanical stress–strain transduction from the primary cell wall tethered to the plasma membrane by a specific arabinogalactan protein (AGP). The resulting stress vector, with direction defined by Hechtian adhesion sites, has a magnitude of a few piconewtons amplified by a hypothetical Hechtian growth oscillator. This paradigm shift involves stress-activated plasma membrane Ca2+ channels and auxin-activated H+-ATPase. The proton pump dissociates periplasmic AGP-glycomodules that bind Ca2+. Thus, as the immediate source of cytosolic Ca2+, an AGP-Ca2+ capacitor directs the vectorial exocytosis of cell wall precursors and auxin efflux (PIN) proteins. In toto, these components comprise the Hechtian oscillator and also the gravisensor. Thus, interdependent auxin and Ca2+ morphogen gradients account for the predominance of AGPs. The size and location of a cell surface AGP-Ca2+ capacitor is essential to differentiation and explains AGP correlation with all stages of morphogenetic patterning from embryogenesis to root and shoot. Finally, the evolutionary origins of the Hechtian oscillator in the unicellular Chlorophycean algae reflect the ubiquitous role of chemiosmotic proton pumps that preceded DNA at the dawn of life.

scholarly journals Role of Xyloglucan in Primary Cell Walls

2008 ◽  
Vol 20 (6) ◽  
pp. 1421-1422 ◽  
Author(s):  
Nancy A. Eckardt
Keyword(s):  
Cell Walls ◽  
Primary Cell

scholarly journals The Role of the Primary Cell Wall in Plant Morphogenesis

2018 ◽  
Author(s):  
Derek T Lamport ◽  
Li Tan ◽  
Michael Held ◽  
Marcia J. Kieliszewski
Keyword(s):  
Cell Wall ◽  
Plasma Membrane ◽  
Computational Modelling ◽  
Primary Cell ◽  
Arabinogalactan Protein ◽  
Primary Cell Wall ◽  
Proton Pumps ◽  
Plant Morphogenesis ◽  
Evolutionary Origins

Morphogenesis remains a riddle, wrapped in a mystery, inside an enigma. It remains a formidable problem viewed from many different perspectives of morphology, genetics, and computational modelling. We propose a biochemical reductionist approach that shows how both internal and external physical forces contribute to plant morphogenesis via mechanical stress-strain transduction from the primary cell wall tethered to the plasma membrane by a specific arabinogalactan protein (AGP). The resulting stress vector with direction defined by Hechtian adhesion sites, has a magnitude of a few picoNewtons amplified by a hypothetical Hechtian growth oscillator. This paradigm shift involves stress activated plasma membrane Ca2+channels and auxin-activated H+-ATPase. The proton pump dissociates periplasmic AGP-glycomodules that bind Ca2+. Thus, as the immediate source of cytosolic Ca2+ an AGP-Ca2+ capacitor directs vectorial exocytosis of cell wall precursors and auxin efflux (PIN) proteins. In toto these components comprise the Hechtian Oscillator and also the gravisensor. Thus interdependent auxin and Ca2+ morphogen gradients account for the predominance of AGPs. The size and location of a cell surface AGP-Ca2+ capacitor is essential to differentiation and explains AGP correlation with all stages of morphogenetic patterning from embryogenesis to root and shoot. Finally, evolutionary origins of the Hechtian Oscillator in the unicellular Chlorophycean algae reflect the ubiquitous role of chemiosmotic proton pumps that preceded DNA at the dawn of life.

scholarly journals Role of the Extensin Superfamily in Primary Cell Wall Architecture

2011 ◽  
Vol 156 (1) ◽  
pp. 11-19 ◽  
Author(s):  
Derek T.A. Lamport ◽  
Marcia J. Kieliszewski ◽  
Yuning Chen ◽  
Maura C. Cannon
Keyword(s):  
Cell Wall ◽  
Primary Cell ◽  
Primary Cell Wall ◽  
Cell Wall Architecture

Role of dactinomycin in the improved survival of children with Wilms' tumor

JAMA ◽  
1966 ◽  
Vol 195 (12) ◽  
pp. 1005-1009 ◽  
Author(s):  
D. J. Fernbach
Keyword(s):  
Wilms Tumor

Role of the allergist in diagnosis and management of patients with uveitis

JAMA ◽  
1966 ◽  
Vol 195 (3) ◽  
pp. 167-172 ◽  
Author(s):  
T. E. Van Metre
Keyword(s):  
Diagnosis And Management
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