Intravenous glial-derived neurotrophic factor gene therapy of experimental Parkinson's disease with Trojan horse liposomes and a tyrosine hydroxylase promoter

2008 ◽  
Vol 10 (3) ◽  
pp. 306-315 ◽  
Author(s):  
Chun-Fang Xia ◽  
Ruben J. Boado ◽  
Yun Zhang ◽  
Chun Chu ◽  
William M. Pardridge
Keyword(s):  
Parkinson’S Disease ◽  
Gene Therapy ◽  
Parkinson's Disease ◽  
Tyrosine Hydroxylase ◽  
Neurotrophic Factor ◽  
Trojan Horse ◽  
Factor Gene ◽  
Glial Derived Neurotrophic Factor ◽  
Tyrosine Hydroxylase Promoter

Trophic Factor Gene Therapy for Parkinson's Disease

2013 ◽  
Vol 28 (1) ◽  
pp. 96-109 ◽  
Author(s):  
Jeffrey H. Kordower ◽  
Anders Bjorklund
Keyword(s):  
Parkinson’S Disease ◽  
Gene Therapy ◽  
Parkinson's Disease ◽  
Trophic Factor ◽  
Factor Gene

scholarly journals Efficient Gene Therapy for Parkinson's Disease Using Astrocytes as Hosts for Localized Neurotrophic Factor Delivery

2012 ◽  
Vol 20 (3) ◽  
pp. 534-543 ◽  
Author(s):  
Anja Drinkut ◽  
Yuliya Tereshchenko ◽  
Jörg B Schulz ◽  
Mathias Bähr ◽  
Sebastian Kügler
Keyword(s):  
Parkinson’S Disease ◽  
Gene Therapy ◽  
Parkinson's Disease ◽  
Neurotrophic Factor ◽  
Efficient Gene

Gene Therapy in the Management of Parkinson’s Disease: Potential of GDNF as a Promising Therapeutic Strategy

2020 ◽  
Vol 20 (3) ◽  
pp. 207-222
Author(s):  
Tapan Behl ◽  
Ishnoor Kaur ◽  
Arun Kumar ◽  
Vineet Mehta ◽  
Gokhan Zengin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Gene Therapy ◽  
Parkinson's Disease ◽  
Neurotrophic Factor ◽  
Dopaminergic Neurons ◽  
Viral Vector ◽  
Neurodegenerative Disorder ◽  
Dopamine Synthesis ◽  
Motor Symptoms ◽  
Ligand Complex

: The limitations of conventional treatment therapies in Parkinson’s disorder, a common neurodegenerative disorder, lead to the development of an alternative gene therapy approach. Multiple treatment options targeting dopaminergic neuronal regeneration, production of enzymes linked with dopamine synthesis, subthalamic nucleus neurons, regulation of astrocytes and microglial cells and potentiating neurotrophic factors, were established. Viral vector-based dopamine delivery, prodrug approaches, fetal ventral mesencephalon tissue transplantation and dopamine synthesizing enzyme encoding gene delivery are significant therapies evidently supported by numerous trials. The review primarily elaborates on the significant role of glial cell-line derived neurotrophic factor in alleviating motor symptoms and the loss of dopaminergic neurons in Parkinson’s disease. Neuroprotective and neuroregenerative effects of GDNF were established via preclinical and clinical study outcomes. The binding of GDNF family ligands with associated receptors leads to the formation of a receptor-ligand complex activating Ret receptor of tyrosine kinase family, which is only expressed in dopaminergic neurons, playing an important role in Parkinson’s disease, via its association with the essential protein encoded genes. Furthermore, the review establishes delivery aspects, like ventricular delivery of recombinant GDNF, intraparenchymal and intraputaminal delivery using infusion catheters. The review highlights problems and challenges of GDNF delivery, and essential measures to overcome them, like gene therapy combinations, optimization of delivery vectors, newer targeting devices, motor symptoms curbing focused ultrasound techniques, modifications in patient selection criteria and development of novel delivery strategies based on liposomes and encapsulated cells, to promote safe and effective delivery of neurotrophic factor and establishment of routine treatment therapy for patients.

Delayed gene therapy of glial cell line-derived neurotrophic factor is efficacious in a rat model of Parkinson's disease

2005 ◽  
Vol 134 (1) ◽  
pp. 155-161 ◽  
Author(s):  
Jie-Sheng Zheng ◽  
Ling-Ling Tang ◽  
Shu-Sen Zheng ◽  
Ren-Ya Zhan ◽  
Yong-Qing Zhou ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Gene Therapy ◽  
Parkinson's Disease ◽  
Cell Line ◽  
Glial Cell ◽  
Rat Model ◽  
Neurotrophic Factor
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