Using disaccharides to enhancein vitro andin vivo transgene expression mediated by a lipid-based gene delivery system

2007 ◽  
Vol 9 (8) ◽  
pp. 659-667 ◽  
Author(s):  
Wen-Chi Tseng ◽  
Chien-Hsiang Tang ◽  
Tsuei-Yun Fang ◽  
Ling-Yu Su
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Transgene Expression ◽  
Gene Delivery System

Reduction-Sensitive Lipopolyamines as a Novel Nonviral Gene Delivery System for Modulated Release of DNA with Improved Transgene Expression

2000 ◽  
Vol 43 (23) ◽  
pp. 4377-4387 ◽  
Author(s):  
Gerardo Byk ◽  
Barbara Wetzer ◽  
Marc Frederic ◽  
Catherine Dubertret ◽  
Bruno Pitard ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Transgene Expression ◽  
Nonviral Gene Delivery ◽  
Gene Delivery System

Improvement of a phiC31 integrase-based gene delivery system that confers high and continuous transgene expression

2011 ◽  
Vol 28 (4) ◽  
pp. 312-319 ◽  
Author(s):  
Satoshi Watanabe ◽  
Shingo Nakamura ◽  
Takayuki Sakurai ◽  
Koji Akasaka ◽  
Masahiro Sato
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Transgene Expression ◽  
Gene Delivery System ◽  
Phic31 Integrase

1004: In-Vivo Transfection of the Rat Corpus Cavernosum Using a Non-Viral, Linear Polyethylenimine Gene Delivery System: A Novel Application

2006 ◽  
Vol 175 (4S) ◽  
pp. 323-324 ◽  
Author(s):  
Joseph Dall'era ◽  
Sweaty Koul ◽  
Jesse Mills ◽  
Jeremy Myers ◽  
Randall B. Meacham ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Corpus Cavernosum ◽  
Gene Delivery System ◽  
System A ◽  
In Vivo Transfection ◽  
Linear Polyethylenimine

Polyplex: A Promising Gene Delivery System

2019 ◽  
Vol 12 (6) ◽  
pp. 4681-4686
Author(s):  
Rohan Aggarwal ◽  
Monika Targhotra ◽  
Bhumika Kumar ◽  
P.K Sahoo ◽  
Meenakshi K Chauhan
Keyword(s):  
Gene Transfer ◽  
Gene Delivery ◽  
Delivery System ◽  
Viral Vectors ◽  
Gene Delivery System ◽  
Cationic Polymers ◽  
Therapeutic Application ◽  
Promising Alternative ◽  
Structure And Stability ◽  
The Past

In the past few years gene delivery system has gained a huge attention owing to its proved efficacy in several diseases especially in those caused by genetic and/oroncological malfunctioning. The effective gene delivery mainly depends on the carrier molecules that can ensure the safe and specific delivery of the nucleic acidmolecules. Viral vectors have been used for a longer period as the gene transfer vehicle. However, these viral vectors have potential immunological disadvantages that made them less preferred. Recently, non-viral vectors such as polyplexes have emerged as a promising alternative for viral vectors. Polyplexes are formed by conjugating a polymer with DNA and in maximum cases the cationic polymers are preferred over others. The structure and stability of the polyplexes depends on various factors. The ability of the polymer to condense the DNA mainly dictates the efficiency of the polyplex mediated transfection. In this review we are going to provide a framework for the synthesis and design of the polyplexes along with the structure and stability of the complexes pertaining to mechanism of action, characterization and therapeutic application, including polyethyleneimine mediated cytotoxicity as well as newer strategies for the generation of better polyplexes.

In vivo uterine local gene delivery system using TAT‐displaying bionanocapsules

2019 ◽  
Vol 21 (12) ◽  
Author(s):  
Kaori Koizumi ◽  
Hitomi Nakamura ◽  
Masumi Iijima ◽  
Takashi Matsuzaki ◽  
Masaharu Somiya ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Gene Delivery System
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