Electroporation enhances reporter gene expression following delivery of naked plasmid DNA to the lung

2007 ◽  
Vol 9 (5) ◽  
pp. 369-380 ◽  
Author(s):  
Ian A. Pringle ◽  
Gerry McLachlan ◽  
David D. S. Collie ◽  
Stephanie G. Sumner-Jones ◽  
Anna E. Lawton ◽  
...  
Keyword(s):  
Gene Expression ◽  
Reporter Gene ◽  
Plasmid Dna ◽  
Reporter Gene Expression ◽  
Naked Plasmid ◽  
Naked Plasmid Dna

scholarly journals Silencing of Reporter Gene Expression in Skin Using siRNAs and Expression of Plasmid DNA Delivered by a Soluble Protrusion Array Device (PAD)

2010 ◽  
Vol 18 (9) ◽  
pp. 1667-1674 ◽  
Author(s):  
Emilio Gonzalez-Gonzalez ◽  
Tycho J Speaker ◽  
Robyn P Hickerson ◽  
Ryan Spitler ◽  
Manuel A Flores ◽  
...  
Keyword(s):  
Gene Expression ◽  
Reporter Gene ◽  
Plasmid Dna ◽  
Reporter Gene Expression

scholarly journals Direct transfer of IL-12 gene into growing Renca tumors.

2000 ◽  
Vol 47 (2) ◽  
pp. 385-391 ◽  
Author(s):  
M Budryk ◽  
U Wilczyńska ◽  
J Szary ◽  
S Szala
Keyword(s):  
Cancer Cells ◽  
Therapeutic Effect ◽  
Reporter Gene ◽  
Plasmid Dna ◽  
Time Span ◽  
Direct Transfer ◽  
Therapeutic Gene ◽  
Naked Dna ◽  
Naked Plasmid ◽  
Naked Plasmid Dna

We investigated the feasibility of transferring naked plasmid DNA containing a therapeutic gene (IL-12) into mice harboring growing Renca tumors. We found that naked DNA transferred into growing Renca and B16(F10) tumors gives higher expression level of reporter gene than complexes of DNA with DDAB/DOPE or DC-Chol/DOPE. Transfer of naked DNA carrying the IL-12 gene into growing Renca tumors causes a distinct therapeutic effect that depends on the time span between inoculation of mice with cancer cells and the beginning of the therapy. Therapy started on day 3 resulted in total cure (100%) of mice.

Uptake and Gene Expression of Naked Plasmid DNA in Cultured Brain Microvessel Endothelial Cells

1998 ◽  
Vol 245 (1) ◽  
pp. 235-239 ◽  
Author(s):  
Masaru Nakamura ◽  
Pablo Davila-Zavala ◽  
Hideaki Tokuda ◽  
Yoshinobu Takakura ◽  
Mitsuru Hashida
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Plasmid Dna ◽  
Naked Plasmid ◽  
Microvessel Endothelial Cells ◽  
Brain Microvessel ◽  
Naked Plasmid Dna

Disposition and Gene Expression Characteristics in Solid Tumors and Skeletal Muscle after Direct Injection of Naked Plasmid DNA in Mice

2003 ◽  
Vol 92 (6) ◽  
pp. 1295-1304 ◽  
Author(s):  
Atsushi Kawase ◽  
Takehiko Nomura ◽  
Kei Yasuda ◽  
Naoki Kobayashi ◽  
Mitsuru Hashida ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Solid Tumors ◽  
Plasmid Dna ◽  
Direct Injection ◽  
Naked Plasmid ◽  
Expression Characteristics ◽  
Naked Plasmid Dna
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