scholarly journals Effect of abdominal visceral fat on mortality risk in patients with severe acute pancreatitis

JGH Open ◽  
2021 ◽  
Author(s):  
Yu Higaki ◽  
Tsutomu Nishida ◽  
Kengo Matsumoto ◽  
Sho Yamaoka ◽  
Naoto Osugi ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Mortality Risk ◽  
Visceral Fat ◽  
Abdominal Visceral Fat

scholarly journals Elevated serum neopterin concentration increases mortality risk in patients with acute pancreatitis

Pteridines ◽  
2019 ◽  
Vol 30 (1) ◽  
pp. 16-20
Author(s):  
Zemin Xiang ◽  
Yijun Gu ◽  
Yuanyuan Huang ◽  
Lefeng Zhang ◽  
Xiaohong Zhang ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Mortality Risk ◽  
Elevated Serum ◽  
Multiple Organ ◽  
Control Group ◽  
Serum Neopterin ◽  
Severity Of Disease ◽  
Significant Difference ◽  
Mild Acute Pancreatitis

Abstract Background The aim of this study was to investigate serum neopterin levels in patients with acute pancreatitis (AP) and its predictive value for mortality in cases of severe acute pancreatitis (SAP). Methods Eighty-two patients with confirmed acute pancreatitis (AP) were included and divided into two groups, mild acute pancreatitis (MAP, n=51) and severe acute pancreatitis (SAP, n=31) according to severity of disease. From the SAP group, 8 cases went on to develop multiple organ dysfunction syndrome (MODS) and 6 subsequently died. Thirty healthy subjects from routine medical examination were included as the control group. The neopterin serum concentrations were determined and compared between groups. Results Serum neopterin concentrations from control, MAP, SAP, SAP_Non-MODS, MODS_survival and MODS_death groups were 6.85±2.42 (nmol/L), 0.91±4.83(nmol/L), 33.11±11.67(nmol/L), 30.39±9.97(nmol/L), 36.40±4.48(nmol/L) and 41.75±15.64(nmol/L) respectively, with statistical significant difference (p<0.05). The sensitivity and specificity for mortality risk were 66.67% (95%CI:22.28-95.67%) and 88.00%(95%CI:68.78-97.45%) respectively, with area under the ROC curve (AUC) of 0.71(95%CI:0.50-0.9), under the cut off value of 40.18. Conclusion: Serum neopterin levels in patients with acute pancreatitis were significantly elevated and correlated with the severity of disease. Neopterin may also be used a serological biomarker of mortality risk in patients with SAP.

scholarly journals Predicting the Severity of Acute Pancreatitis

2021 ◽  
Vol 26 (3) ◽  
pp. 168-175
Author(s):  
Song Yi Yu ◽  
Yun Chae Lee ◽  
Seong-Hun Kim ◽  
Seung Ok Lee
Keyword(s):  
Acute Pancreatitis ◽  
Organ Failure ◽  
Disease Severity ◽  
Severe Acute Pancreatitis ◽  
Mortality Risk ◽  
Large Scale ◽  
Time Of Death ◽  
Single Test ◽  
Serological Tests ◽  
Evaluation Measures

Acute pancreatitis has two mortality peaks, which occurs within the first 2 weeks due to organ failure and then weeks or months later as result of multi-organ failure and local complications. Although there have been several clinical and multidisciplinary evaluation measures, imaging tests, and serological tests proposed to forecast severe acute pancreatitis, there is still no single test available to reliably predict the disease severity and time of death. Future large-scale studies are required to develop an assessment scale that can accurately predict the prognosis and mortality risk of severe acute pancreatitis.

scholarly journals The influence of abdominal visceral fat on inflammatory pathways and mortality risk in obstructive lung disease

2012 ◽  
Vol 96 (3) ◽  
pp. 516-526 ◽  
Author(s):  
Bram van den Borst ◽  
Harry R Gosker ◽  
Annemarie Koster ◽  
Binbing Yu ◽  
Stephen B Kritchevsky ◽  
...  
Keyword(s):  
Lung Disease ◽  
Mortality Risk ◽  
Visceral Fat ◽  
Obstructive Lung Disease ◽  
Inflammatory Pathways ◽  
Abdominal Visceral Fat

Gut permeabillity and nitric oxide: Evidence for an endotoxin mediated inflammatory response in severe acute pancreatitis

2001 ◽  
Vol 120 (5) ◽  
pp. A468-A469
Author(s):  
S RAHMAN ◽  
B AMMORI ◽  
I MARTIN ◽  
G BARCLAY ◽  
M LARVIN ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Acute Pancreatitis ◽  
Inflammatory Response ◽  
Severe Acute Pancreatitis

Clinical Profile and Outcomes in Patients with Acute Pancreatitis attending a Teaching Hospital at Gandaki Province, Nepal

2020 ◽  
Vol 16 (3) ◽  
Author(s):  
Subash Bhattarai ◽  
Merina Gyawali
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Age Groups ◽  
Data Entry ◽  
Kidney Injury ◽  
Severity Index ◽  
Clinical Profile ◽  
Cross Sectional ◽  
Systemic Complications ◽  
Keywords Alcohol

Background: Acute pancreatitis (AP) is inflammatory process of pancreas presenting with acute abdominal pain.The majority of patients have mild disease. Some patients develop local and systemic complications with increased morbidity and mortality. This study was undertaken to describe the clinical profile and outcomes in patients with acute pancreatitis.   Methods:  A cross-sectional hospital based study comprising of 62 consecutive patients with acute pancreatitis were enrolled between Jan 2019 to August 2020. Clinical profile at admission, complications and clinical outcomes including mortality were studied. Patients were classified into mild, moderately severe and severe acute pancreatitis based on revised Atlanta classification and modified CT severity index.  Data entry was done in Statistical Packages for the Social Sciences version 20. Results: The mean age of study subjects was 44±10.87 years with 43 (56%) males and 19 (44%) females (M:F=2.1:1). The commonest etiology of pancreatitis was alcohol (53.2%) followed by biliary pancreatitis (37.1%)  The most common presentation was abdominal pain (100%). The most common complication was pancreatic necrosis (21%) followed by acute kidney injury (19.4%) and pleural effusion (17.3%). Majority( 72.6%) was mild and 17.7% had severe acute pancreatitis. Mortality was seen in 6.5% patients. Mortality was observed in patients with persistent complications, organ failure, low serum calcium and high modified CT severity index.   Conclusions: Alcohol and gallstones were the two main etiologies of acute pancreatitis and were common in males, and in middle age groups. Majority presented with mild severity. Mortality was observed in some patients with severe acute pancreatitis.   Keywords: alcohol; biliary; CT severity index; mortality; outcome; pancreatitis          

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