scholarly journals The natural history of low‐grade dysplasia in Barrett's esophagus and risk factors for progression

JGH Open ◽  
2021 ◽  
Author(s):  
Mohamed Hussein ◽  
Vinay Sehgal ◽  
Sarmed Sami ◽  
Paul Bassett ◽  
Rami Sweis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Natural History ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Low Grade ◽  
History Of ◽  
Low Grade Dysplasia

scholarly journals Sa1160 – The Natural History of Low Grade Dysplasia in Patients with Barrett's Esophagus: 12 Year Retrospective Analysis from a Tertiary Centre

2019 ◽  
Vol 156 (6) ◽  
pp. S-289-S-290
Author(s):  
Mohamed Hussein ◽  
Vinay Sehgal ◽  
Cormac Magee ◽  
Sarmed S. Sami ◽  
Matthew Banks ◽  
...  
Keyword(s):  
Natural History ◽  
Retrospective Analysis ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Low Grade ◽  
Tertiary Centre ◽  
History Of ◽  
Low Grade Dysplasia

Su1447 Prevalence and Natural History of Low-Grade Dysplasia in Patients With Barrett's Esophagus

2013 ◽  
Vol 77 (5) ◽  
pp. AB327 ◽  
Author(s):  
Christos Zavos ◽  
Romy E. Verbeek ◽  
Max Leenders ◽  
Leon M. Moons ◽  
Frank P. Vleggaar ◽  
...  
Keyword(s):  
Natural History ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Low Grade ◽  
History Of ◽  
Low Grade Dysplasia

scholarly journals Persistent confirmed low-grade dysplasia in Barrett's esophagus is a risk factor for progression to high-grade dysplasia and adenocarcinoma in a US Veterans cohort

2019 ◽  
Author(s):  
K Y Song ◽  
A J Henn ◽  
A A Gravely ◽  
H Mesa ◽  
S Sultan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Independent Risk Factor ◽  
High Grade Dysplasia ◽  
Low Grade ◽  
High Grade ◽  
Increased Risk ◽  
Low Grade Dysplasia

SUMMARY Patients with Barrett's esophagus (BE) and low-grade dysplasia (LGD) are at increased risk of esophageal adenocarcinoma (EAC), although many regress to nondysplastic BE. This has significant clinical importance for patients being considered for endoscopic eradication therapy. Our aim is to determine the risk for progression in patients with confirmed persistent LGD. We performed a single-center retrospective cohort study of patients with BE and confirmed LGD between 2006 and 2016. Confirmed LGD was defined as LGD diagnosed by consensus conference with an expert GI pathologist or review by an expert GI pathologist and persistence as LGD present on subsequent endoscopic biopsy. The primary outcome was the incidence rate of HGD (high-grade dysplasia)/EAC. Secondary outcomes included risk factors for dysplastic progression. Risk factors for progression were assessed using univariate and multivariate analysis with logistic regression. Of 69 patients (mean age 65.2 years) with confirmed LGD were included. In total, 16 of 69 patients (23.2%) with LGD developed HGD/EAC during a median follow-up of 3.74 years (IQR, 1.24–5.45). For persistent confirmed LGD, the rate was 6.44 (95% confidence interval (CI), 2.61–13.40) compared to 2.61 cases per 100 patient-years (95% CI, 0.83–6.30) for nonpersistent LGD. Persistent LGD was found in only 29% of patients. Persistent LGD was an independent risk factor for the development of HGD/EAC (OR 4.18; [95% CI, 1.03–17.1]). Persistent confirmed LGD, present in only 1/3 of patients, was an independent risk factor for the development of HGD/EAC. Persistence LGD may be useful in decision making regarding the management of BE.

838 Risk Factors for Progression of Barrett's Esophagus With Low-Grade Dysplasia

2016 ◽  
Vol 150 (4) ◽  
pp. S177 ◽  
Author(s):  
Anna Tavakkoli ◽  
Henry D. Appelman ◽  
David G. Beer ◽  
Chaitra Madiyal ◽  
Maryam Khodadost ◽  
...  
Keyword(s):  
Risk Factors ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Low Grade ◽  
Low Grade Dysplasia

Risk Factors for Progression of Low-Grade Dysplasia in Patients With Barrett's Esophagus

2011 ◽  
Vol 141 (4) ◽  
pp. 1179-1186.e1 ◽  
Author(s):  
Sachin Wani ◽  
Gary W. Falk ◽  
Jane Post ◽  
Lisa Yerian ◽  
Matthew Hall ◽  
...  
Keyword(s):  
Risk Factors ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Low Grade ◽  
Low Grade Dysplasia

scholarly journals Persistent indefinite for dysplasia in Barrett’s esophagus is a risk factor for dysplastic progression to low-grade dysplasia

2020 ◽  
Vol 33 (9) ◽  
Author(s):  
Andrew J Henn ◽  
Kevin Y Song ◽  
Amy A Gravely ◽  
Hector Mesa ◽  
Shahnaz Sultan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multivariate Analysis ◽  
Risk Factor ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Smoking History ◽  
Low Grade ◽  
Indefinite For Dysplasia ◽  
Low Grade Dysplasia

Summary Patients with Barrett’s esophagus (BE) are at increased risk of esophageal adenocarcinoma (EAC). The risk is largely based on the degree of dysplasia. Dysplasia cannot always be differentiated from inflammatory changes, and therefore may be classified as indefinite for dysplasia (IND). The risk of progressive dysplasia in patients with IND is unclear. Our aim is to characterize the risk of progression in US veterans with BE-IND. We performed a single-center retrospective cohort study of patients with BE-IND between 2006 and 2016. All IND was diagnosed by consensus conference with an expert gastrointestinal (GI) pathologist or review by an expert GI pathologist and persistence was defined as IND present on subsequent endoscopic biopsy. The primary outcome was the incidence rate of high-grade dysplasia (HGD)/EAC. Secondary outcomes included any progression including incident low-grade dysplasia (LGD), any prevalent dysplasia and risk factors for dysplastic progression, namely persistent IND. Risk factors for progression were assessed using univariate and multivariate analysis with logistic regression. Among 107 patients with BE-IND, there were no incident cases of HGD/EAC. Twenty patients (18.7%) developed incident LGD during a median follow-up of 2.39 years (interquartile range, 1.13–5.17). The annual rate of progression to LGD was 5.95 per 100 patient-years (95% CI, 3.73–9.02). Prevalent dysplasia was common (9.3%). Eight patients had prevalent LGD, one patient had prevalent HGD and one patient had prevalent EAC. Twenty-eight patients (30.1%) were found to have persistent IND. Among those with persistent IND, 10 (36%) patients progressed to LGD (none to HGD/EAC). The progression rate to LGD for patients with persistent IND was 7.86 (95% CI, 3.99–14.02) cases per 100 patient-years versus 4.78 (95% CI, 2.48–8.52) for nonpersistent IND (P = 0.036). The odds ratio for progression to LGD in persistent IND was 3.06 (95% CI, 1.08–8.64). In multivariate analysis adjusting for age, smoking history, presence of hiatal hernia and BMI > 30, persistent IND remained significant (OR 3.23; 95% CI, 1.04–9.98). Regression to nondysplastic BE was very common. Seventy-one (61%) patients developed complete and sustained regression of all dysplastic changes at last follow-up. Persistent IND, present in one-third of patients with IND, is an independent risk factor for progression to LGD. Although no patients in this cohort developed HGD/EAC, prevalent dysplasia was common (9.3%). Taken together, patients with IND should receive close surveillance for both prevalent and incident dysplasia especially if IND is persistent.

Mo1854 Risk Factors for Predicting Neoplastic Progression in Patients With Barrett's Esophagus and Low-Grade Dysplasia

2013 ◽  
Vol 144 (5) ◽  
pp. S-675-S-676
Author(s):  
Christos Zavos ◽  
Romy E. Verbeek ◽  
Max Leenders ◽  
Leon M. Moons ◽  
Frank P. Vleggaar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Low Grade ◽  
Neoplastic Progression ◽  
Low Grade Dysplasia
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