scholarly journals How did the ancient bacterium, Helicobacter pylori , cause an epidemic of chronic duodenal ulceration?

JGH Open ◽  
2021 ◽  
Author(s):  
Ian C Roberts‐Thomson
Keyword(s):  
Helicobacter Pylori ◽  
Duodenal Ulceration

Gastric mucosal hydrophobicity in duodenal ulceration: Role of Helicobacter pylori infection density and mucus lipids

1997 ◽  
Vol 113 (2) ◽  
pp. 449-454 ◽  
Author(s):  
M Asante ◽  
H Ahmed ◽  
P Patel ◽  
T Davis ◽  
C Finlayson ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Helicobacter Pylori Infection ◽  
Duodenal Ulceration ◽  
Infection Density

scholarly journals The Pathogenesis of Duodenal Ulcer and the Role of Helicobacter pylori in This Disease: A Systematic Review

2020 ◽  
Author(s):  
Simon Xin Min Dong ◽  
Katelynn Jean Rowe ◽  
Connie Ching Yuen Chang
Keyword(s):  
Systematic Review ◽  
Duodenal Ulcer ◽  
Helicobacter Pylori ◽  
Gastric Acid ◽  
Late Phase ◽  
Pathological Process ◽  
Duodenal Ulceration ◽  
Controversial Issues ◽  
Peptic Ulcers ◽  
Existing Data

Background: The pathogenesis of duodenal ulcer has never been explained although the first description of this disease in medical literature appeared in 1817. Marshall et al. concluded that Helicobacter pylori was the most important etiological factor for duodenal ulcer in 1988, but the etiology based on this bacterium is controversial and how the bacterial infection leads to ulceration is presently unknown. Objectives: This study aims to identify the cause of duodenal ulcer, address the controversial issues surrounding Helicobacter pylori, elucidate the roles of gastric acid, and describe the pathological process of duodenal ulceration. Methods: First, a comprehensive systematic review on peptic ulcers (including gastric ulcer and duodenal ulcer) was conducted and the results were summarized. Second, a recently published causal relationship was employed to identify the etiology of peptic ulcers. Third, novel concepts and methods were applied to analyze the existing data on duodenal ulcer. Results: The etiology of duodenal ulcer and the roles of Helicobacter pylori and gastric acid in this disease were identified. The controversies surrounding Helicobacter pylori were addressed, and many characteristics and phenomena/observations of duodenal ulcer were elucidated. The pathological process of duodenal ulceration was described. Conclusion: Existing data accumulated over the past 300 years was sufficient, when analyzed using novel concepts, to understand the pathogenesis of duodenal ulcer. Duodenal ulcer is not an infectious disease caused by the infection of Helicobacter pylori, but a psychosomatic disease triggered by psychological stress. Helicobacter pylori plays a secondary role in only the late phase of duodenal ulceration.

scholarly journals A study of the pathogenesis of Helicobacter pylori negative chronic duodenal ulceration.

Gut ◽  
1993 ◽  
Vol 34 (6) ◽  
pp. 762-768 ◽  
Author(s):  
K E McColl ◽  
A M el-Nujumi ◽  
R S Chittajallu ◽  
S W Dahill ◽  
C A Dorrian ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Duodenal Ulceration
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