scholarly journals Early radiological response evaluation with response evaluation criteria in solid tumors 1.1 stratifies survival in hepatocellular carcinoma patients treated with lenvatinib

JGH Open ◽  
2020 ◽  
Vol 4 (6) ◽  
pp. 1183-1190
Author(s):  
Shun Kaneko ◽  
Kaoru Tsuchiya ◽  
Yutaka Yasui ◽  
Kento Inada ◽  
Sakura Kirino ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Solid Tumors ◽  
Evaluation Criteria ◽  
Response Evaluation ◽  
Radiological Response ◽  
Response Evaluation Criteria

scholarly journals Analysis of Survival and Response to Lenvatinib in Unresectable Hepatocellular Carcinoma

Cancers ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 320
Author(s):  
Kei Amioka ◽  
Tomokazu Kawaoka ◽  
Masanari Kosaka ◽  
Yusuke Johira ◽  
Yuki Shirane ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Multivariate Analysis ◽  
Solid Tumors ◽  
Evaluation Criteria ◽  
Initial Evaluation ◽  
Radiological Evaluation ◽  
Response Evaluation ◽  
Unresectable Hepatocellular Carcinoma ◽  
Radiological Response ◽  
Response Evaluation Criteria

The association between radiological response and overall survival (OS) was retrospectively evaluated in patients treated with lenvatinib as a first-line systemic treatment for unresectable hepatocellular carcinoma. A total of 182 patients with Child–Pugh class A liver function and an Eastern Cooperative Oncology Group performance status of zero or one were enrolled. Radiological evaluation was performed using Response Evaluation Criteria in Solid Tumors (RECIST) and modified Response Evaluation Criteria in Solid Tumors (mRECIST). Initial radiological evaluation confirmed significant stratification of OS by efficacy judgment with both RECIST and mRECIST, and that initial radiological response was an independent prognostic factor for OS on multivariate analysis. Furthermore, in patients with stable disease (SD) at initial evaluation, macrovascular invasion at the initial evaluation on RECIST and modified albumin–bilirubin grade at initial evaluation on mRECIST were independent predictors of OS on multivariate analysis. In conclusion, if objective response is obtained at the initial evaluation, continuation of treatment appears desirable because prolonged OS can be expected; but, if SD is obtained at the initial evaluation, one should determine whether to continue or switch to the next treatment, with careful consideration of factors related to the tumor and hepatic reserve at the initial evaluation.

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