scholarly journals Pilot study identifying circulating miRNA signature specific to alcoholic chronic pancreatitis and its implication on alcohol‐mediated pancreatic tissue injury

JGH Open ◽  
2020 ◽  
Vol 4 (6) ◽  
pp. 1079-1087
Author(s):  
Bishnupriya Chhatriya ◽  
Piyali Sarkar ◽  
Debashis Nath ◽  
Sukanta Ray ◽  
Kshaunish Das ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Pilot Study ◽  
Tissue Injury ◽  
Pancreatic Tissue ◽  
Mirna Signature ◽  
Circulating Mirna ◽  
Alcoholic Chronic Pancreatitis

Pilot study on circulating miRNA signature in children with obesity born small for gestational age and appropriate for gestational age

2018 ◽  
Vol 13 (12) ◽  
pp. 803-811 ◽  
Author(s):  
F. Marzano ◽  
M. F. Faienza ◽  
M. F. Caratozzolo ◽  
G. Brunetti ◽  
M. Chiara ◽  
...  
Keyword(s):  
Pilot Study ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Mirna Signature ◽  
Circulating Mirna ◽  
Appropriate For Gestational Age

scholarly journals The Analgesic Effect of the Mitochondria-Targeted Antioxidant SkQ1 in Pancreatic Inflammation

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Maximilian Weniger ◽  
Leonard Reinelt ◽  
Jens Neumann ◽  
Lesca Holdt ◽  
Matthias Ilmer ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Chronic Pancreatitis ◽  
Analgesic Effect ◽  
Tissue Injury ◽  
Behavioral Observation ◽  
Pancreatic Tissue ◽  
Mechanical Sensitivity ◽  
Risks And Benefits ◽  
Reduction Of Pain ◽  
Acute And Chronic Pancreatitis

Background. Chronic pancreatitis is one of the main risk factors for pancreatic cancer. In acute and chronic pancreatitis, oxidative stress is thought to play a key role. In this respect, the recently described mitochondria-targeted antioxidant SkQ1 effectively scavenges reactive oxygen species at nanomolar concentrations. Therefore, we aimed to characterize the influence of SkQ1 on tissue injury and pain in acute and chronic pancreatitis.Methods. Both acute and chronic pancreatitis were induced in C57BL/6 mice by intraperitoneal cerulein injections and treatment with SkQ1 was carried out by peroral applications. Hyperalgesia was assessed by behavioral observation and measurement of abdominal mechanical sensitivity. Blood serum and pancreatic tissue were harvested for analysis of lipase and histology.Results. SkQ1 did not influence pain, serological, or histological parameters of tissue injury in acute pancreatitis. In chronic pancreatitis, a highly significant reduction of pain-related behavior (p<0.0001) was evident, but histological grading revealed increased tissue injury in SkQ1-treated animals (p=0.03).Conclusion. After SkQ1 treatment, tissue injury is not ameliorated in acute pancreatitis and increased in chronic pancreatitis. However, we show an analgesic effect in chronic pancreatitis. Further studies will need to elucidate the risks and benefits of mitochondria-targeted antioxidants as an analgesic.

scholarly journals Non-alcoholic duct destructive chronic pancreatitis

Gut ◽  
1997 ◽  
Vol 41 (2) ◽  
pp. 263-268 ◽  
Author(s):  
N Ectors ◽  
B Maillet ◽  
R Aerts ◽  
K Geboes ◽  
A Donner ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Chronic Pancreatitis ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Morphological Changes ◽  
Inflammatory Cells ◽  
Pancreatic Disease ◽  
Pancreatic Tissue ◽  
Duct Obstruction ◽  
Alcoholic Chronic Pancreatitis

Background—The pathology of non-alcoholic chronic pancreatitis has not yet been sufficiently studied.Aims—To identify the major changes of pancreatic tissue in patients surgically treated for non-alcoholic chronic pancreatitis.Patients—Pancreatectomy specimens from 12 patients with non-alcoholic chronic pancreatitis, including four patients with autoimmune or related diseases (Sjögren’s syndrome, primary sclerosing cholangitis, ulcerative colitis, and Crohn’s disease), were reviewed.Methods—Morphological changes were studied histologically and immunohistochemically (to type inflammatory cells) and compared with the pancreatic alterations found in 12 patients with alcoholic chronic pancreatitis.Results—In patients with non-alcoholic chronic pancreatitis, with or without associated autoimmune or related diseases, pancreatic inflammation particularly involved the ducts, commonly resulting in duct obstruction and occasionally duct destruction. None of these features was seen in alcoholic chronic pancreatitis which, however, showed pseudocysts and calcifications.Conclusion—The pancreatic changes in patients with non-alcoholic chronic pancreatitis clearly differ from those with alcoholic chronic pancreatitis. The term chronic duct destructive pancreatitis is suggested for this type of pancreatic disease.

scholarly journals Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis

PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0165567 ◽  
Author(s):  
Karianne Fjeld ◽  
Sebastian Beer ◽  
Marianne Johnstone ◽  
Constantin Zimmer ◽  
Joachim Mössner ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Chronic Pancreatitis ◽  
Tandem Repeats ◽  
Alcoholic Liver Cirrhosis ◽  
Alcoholic Chronic Pancreatitis

Comparison of Endoscopic Retrograde Pancreatography with Functional and Histologic Changes in Chronic Pancreatitis

1987 ◽  
Vol 28 (3) ◽  
pp. 289-293 ◽  
Author(s):  
H. A. Heij ◽  
H. Obertop ◽  
M. van Blankenstein ◽  
G. A. J. J. Nix ◽  
D. L. Westbroek
Keyword(s):  
Chronic Pancreatitis ◽  
Discriminant Analysis ◽  
Test Data ◽  
Pancreatic Surgery ◽  
Pancreatic Disease ◽  
Pancreatic Tissue ◽  
Endoscopic Retrograde Pancreatography ◽  
Endoscopic Retrograde ◽  
The Relationship ◽  
Histologic Changes

The findings from endoscopic retrograde pancreatography (ERP) and secretin-CCK test data were compared in 69 patients: 36 with chronic pancreatitis, 9 with possible chronic pancreatitis, and 24 without chronic pancreatic disease. The ERP findings were also compared with the histologic changes in pancreatic tissue in 18 patients who underwent pancreatic surgery for chronic pancreatitis. ERP films were reviewed according to the criteria proposed by Kasugai et coll. (8) with special attention paid to the side branches. Secretin-CCK test data were interpreted using the discriminant analysis. A good correlation between bicarbonate and chymotrypsin output and ductular changes at ERP was found. The results of ERP and the secretin-CCK test were compatible in 86 per cent of the patients. The relationship between ERP findings and histologic changes was not straightforward. It was concluded that ERP and the secretin-CCK test are complementary in the diagnosis of chronic pancreatitis. ERP does not necessarily represent the histology in chronic pancreatitis.

scholarly journals Vascularisation Pattern of Chronic Pancreatitis Compared with Pancreatic Carcinoma: Results from Contrast-Enhanced Endoscopic Ultrasound

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Michael Hocke ◽  
Christoph F. Dietrich
Keyword(s):  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Pancreatic Carcinoma ◽  
Endoscopic Ultrasound ◽  
Clinical Medicine ◽  
Pancreatic Tissue ◽  
Mechanical Index ◽  
Contrast Enhanced ◽  
Inflammatory Processes ◽  
Doppler Techniques

Discriminating between focal chronic pancreatitis and pancreatic cancer is always a challenge in clinical medicine. Contrast-enhanced endoscopic ultrasound using Doppler techniques can uniquely reveal different vascularisation patterns in pancreatic tissue alterated by chronic inflammatory processes and even allows a discrimination from pancreatic cancer. This paper will describe the basics of contrast-enhanced high mechanical index endoscopic ultrasound (CEHMI EUS) and contrast enhanced low mechanical index endoscopic ultrasound (CELMI EUS) and explain the pathophysiological differences of the vascularisation of chronic pancreatitis and pancreatic carcinoma. Furthermore it will discuss how to use these techniques in daily clinical practice.

Comparison of plasmapheresis efficacy and complex antioxidant therapy in patients with comorbid course of chronic pancreatitis and chronic obstructive pulmonary disease

2014 ◽  
Vol 18 (4 (72)) ◽  
Author(s):  
O. S. Khukhlina ◽  
O. O. Ursul ◽  
V. S. Smandych
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Chronic Pancreatitis ◽  
Pulmonary Disease ◽  
Underlying Disease ◽  
Pancreatic Tissue ◽  
Inhalation Therapy ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Complex Therapy ◽  
Reduced Intensity

60 patients with chronic obstructive pulmonary disease (COPD) and chronic pancreatitis (CP) were examined in the dynamics of treatment. The complex therapy of patients with COPD and CP including inhalation therapy with Thiotropium bromide, Serrathiopeptidase and Emoxypin promoted reduced intensity of oxidative stress, restoration of antioxidant protective components activity and natural detoxication system, intensified the activity of enzymatic, Hagemmandependant fibrinolysis and collagenosis, improving the processes of microcirculation, elimination of ischemia and swelling of the pancreatic tissue, quick removal of clinical exacerbation signs of the underlying disease and comorbid diseases. According to the correction degree of enzyme deviation syndrome in the blood, intensity of nitrositic stress and endogenic intoxication in patients with COPD and CP, the effect of 30-day intake of Serrathiopeptidase and 15-day intake of Emoxypin is equal to the efficacy of five plasmapheresis sessions.

Anti-Ulcer Agent, Cetraxate Hydrochloride (Neuer®), Prevents Subcellular Redistribution of Lysosomal Enzyme in Caerulein-Induced Pancreatitis in the Rat

1994 ◽  
Vol 22 (2) ◽  
pp. 107-112
Author(s):  
T Hirano ◽  
S Takeuchi
Keyword(s):  
Chronic Pancreatitis ◽  
Protective Effect ◽  
Lysosomal Enzyme ◽  
Cathepsin B ◽  
Exocrine Pancreas ◽  
Pancreatic Tissue ◽  
Lysosomal Fraction ◽  
Pancreatic Injuries

The protective effect of an anti-ulcer agent, cetraxate hydrochloride [4-(2-carboxyethyl)phenyltrans-4-aminomethylcyclohexanecarboxylate hydrochloride], on the exocrine pancreas in caerulein-induced pancreatitis of rats was investigated. Hyperamylasaemia, pancreatic oedema and activation of trypsinogen in the pancreatic tissue, as well as subcellular redistribution of the lysosomal enzyme, cathepsin B, from the lysosomal fraction to the zymogen fraction, were prevented by infusion of 20 mg/kg.h cetraxate for 2 h before caerulein infusion and throughout the 3.5 h of caerulein infusion (5 μ-g/kg.h). The results indicate that cetraxate plays its protective roles against pancreatitis by inhibiting the redistribution of lysosomal enzyme and by activation of trypsinogen; such activities may be clinically useful in preventing pancreatic injuries, particularly in patients with chronic pancreatitis.

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