scholarly journals Neutrophil gelatinase‐associated lipocalin: An early biomarker for predicting acute kidney injury and severity in patients with acute pancreatitis

JGH Open ◽  
2018 ◽  
Vol 3 (2) ◽  
pp. 105-110 ◽  
Author(s):  
Pradeep K Siddappa ◽  
Rakesh Kochhar ◽  
Pooja Sarotra ◽  
Bikas Medhi ◽  
Vivekanand Jha ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Acute Pancreatitis ◽  
Kidney Injury ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Early Biomarker ◽  
Neutrophil Gelatinase

Sa1351 Neutrophil Gelatinase-Associated Lipocalin: An Early Biomarker for Predicting Acute Kidney Injury in Patients With Acute Pancreatitis

2013 ◽  
Vol 144 (5) ◽  
pp. S-271 ◽  
Author(s):  
Pradeep Kumar Siddappa ◽  
Sreekanth Appasani ◽  
Vivekanand Jha ◽  
Ragesh B. Thandassery ◽  
Jahangeer Basha ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Acute Pancreatitis ◽  
Kidney Injury ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Early Biomarker ◽  
Neutrophil Gelatinase

Urinary neutrophil gelatinase-associated lipocalin as an early biomarker for acute kidney injury in dogs

2020 ◽  
Vol 255 ◽  
pp. 105423
Author(s):  
S. Scheemaeker ◽  
E. Meyer ◽  
J.P. Schoeman ◽  
P. Defauw ◽  
L. Duchateau ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Early Biomarker ◽  
Neutrophil Gelatinase

scholarly journals SP214DETERMINATION OF NEUTROPHIL GELATINASE - ASSOCIATED LIPOCALIN AS EARLY MARKER OF ACUTE KIDNEY INJURY IN ACUTE PANCREATITIS

2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i157-i158
Author(s):  
Agnieszka Gala-Ba˛dzińska ◽  
Mateusz Sporek ◽  
Paulina Dumnicka ◽  
Marek Kuzniewski ◽  
Malgorzata Mazur-Laskowska ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Acute Pancreatitis ◽  
Kidney Injury ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Early Marker ◽  
Neutrophil Gelatinase

scholarly journals Role of Urine Neutrophil Gelatinase-Associated Lipocalin in the Early Diagnosis of Amphotericin B-Induced Acute Kidney Injury

2015 ◽  
Vol 59 (11) ◽  
pp. 6913-6921 ◽  
Author(s):  
Paulo Novis Rocha ◽  
Michael Nascimento Macedo ◽  
Carla Dinamérica Kobayashi ◽  
Lis Moreno ◽  
Luiz Henrique Santos Guimarães ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Amphotericin B ◽  
Area Under The Curve ◽  
Kidney Injury ◽  
Clinical Settings ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Urine Biomarkers ◽  
Early Biomarker ◽  
Neutrophil Gelatinase

ABSTRACTDetermination of the neutrophil gelatinase-associated lipocalin (NGAL) level can be used to detect acute kidney injury (AKI) earlier than determination of the serum creatinine (SCr) level in settings such as cardiac surgery, contrast nephropathy, and intensive care units. We hypothesized that urine NGAL (UrNGAL) would be an early biomarker of drug nephrotoxicity. To test this, we studied hemodynamically stable patients treated with amphotericin B (AmB). We measured the SCr and UrNGAL levels at the baseline and daily after initiation of AmB up to day 14 or development of AKI by the use of the SCr criterion. AKI was defined according to a Kidney Disease: Improving Global Outcomes (KDIGO) criterion (an increase in the SCr level by ≥0.3 mg/dl within 48 h or an SCr level ≥1.5 times the baseline level within 7 days). We studied 24 patients with a mean age of 48.4 ± 16.4 years. Most patients were male, and the patients received AmB (12 received AmB deoxycholate and 12 received liposomal AmB) for the treatment of leishmaniasis (91.7%). Overall, 17/24 patients fulfilled a KDIGO criterion for AKI. Peak UrNGAL levels were higher in patients with AKI than in patients without AKI and in recipients of AmB deoxycholate than in recipients of liposomal AmB. The diagnostic performance of the UrNGAL level on day 5 for the detection of AKI was moderate, with the area under the curve (AUC) being 0.68 (95% confidence interval [CI], 0.41 to 0.95). In the subgroup receiving AmB deoxycholate, however, the AUC rose to 0.89 (95% CI, 0.67 to 1.00). In a patient-level analysis, we found that AKI could be detected 3.2 days earlier by the use of the UrNGAL criterion than by the use of the SCr criterion (times to AKI by the UrNGAL and SCr criteria, 3.7 ± 2.5 versus 6.9 ± 3.3 days, respectively;P= 0.001). Future studies should evaluate if a treatment strategy oriented toward evaluation of UrNGAL levels will improve outcomes. These findings for AmB-induced AKI in leishmaniasis patients could serve as a basis for the investigation of urine biomarkers in the early detection of drug nephrotoxicity in other clinical settings.

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