scholarly journals Serotonin syndrome after an overdose of over‐the‐counter medicine containing dextromethorphan

2021 ◽  
Author(s):  
Nina Omoto ◽  
Yohei Kanzawa ◽  
Naoto Ishimaru ◽  
Saori Kinami
Keyword(s):  
Serotonin Syndrome ◽  
Over The Counter

scholarly journals Serotonin Toxicity: Implications for Clinical Practice

2016 ◽  
Vol 13 (3) ◽  
Author(s):  
Auston Rotheram ◽  
Wayne Harris ◽  
Colin Curtain ◽  
David Nihill
Keyword(s):  
Adverse Reaction ◽  
Prescription Drugs ◽  
Serotonin Syndrome ◽  
Management Strategies ◽  
Clinical Information ◽  
Over The Counter ◽  
Life Threatening ◽  
Serotonergic Drugs ◽  
High Index Of Suspicion ◽  
Serotonin Toxicity

Serotonin toxicity, or serotonin syndrome, is a potentially life threatening adverse reaction to the use of one or more serotonergic drugs. Patients presenting with low level obscure symptoms may have pathophysiology rooted in adverse dopamine and serotonergic poly-pharmacy reactions involving illegal, over-the-counter and/or prescription drugs. In this clinical information paper an overview of serotonin toxicity, diagnostic criteria, and management strategies will be offered. Cultivating a high index of suspicion for serotonin toxicity across a broad patient demographic is recommended

The serotonin syndrome associated with paroxetine, an over-the-counter cold remedy, and vascular disease

1994 ◽  
Vol 12 (6) ◽  
pp. 642-644 ◽  
Author(s):  
Brian P. Skop ◽  
Jeff A. Finkelstein ◽  
Thomas R. Mareth ◽  
Michael R. Magoon ◽  
Thomas M. Brown
Keyword(s):  
Vascular Disease ◽  
Serotonin Syndrome ◽  
Over The Counter ◽  
Cold Remedy

Acetaminophen: Neonatal hepatotoxicity due to late pregnancy exposure

1987 ◽  
Vol 45 ◽  
pp. 718-719
Author(s):  
G.A. Miranda ◽  
M.A. Arroyo ◽  
C.A. Lucio ◽  
M. Mongeotti ◽  
S.S. Poolsawat
Keyword(s):  
Low Dose ◽  
Fetal Liver ◽  
Late Pregnancy ◽  
Toxic Chemicals ◽  
Control Group ◽  
High Dose ◽  
Over The Counter ◽  
Liver And Kidney ◽  
Neonatal Liver ◽  
Childbearing Women

Exposure to drugs and toxic chemicals, during late pregnancy, is a common occurrence in childbearing women. Some studies have reported that more than 90% of pregnant women use at least 1 prescription; of this, 60% used more than one. Another study indicated that 80% of the consumed drugs were not prescribed, and of this figure, 95% were “over-the-counter” drugs. Acetaminophen, the safest of all over-the-counter drugs, has been reported to induce fetal liver necrosis in man and animals and to have abortifacient and embryocidal action in mice. This study examines the degree to which acetaminophen affects the neonatal liver and kidney, when a fatty diet is simultaneously fed to the mother during late pregnancy.Timed Swiss Webster female mice were gavaged during late pregnancy (days 16-19) with fat suspended acetaminophen at a high dose, HD = 84.50 mg/kg, and a low dose, LD = 42.25 mg/kg; a control group received fat alone.

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