scholarly journals Significance of repeat magnetic resonance imaging in diagnosing vertebral osteomyelitis

2018 ◽  
Vol 20 (2) ◽  
pp. 68-71
Author(s):  
Naoko Kamiya ◽  
Shuji Hatakeyama ◽  
Naoki Kanda ◽  
Sho Yonaha ◽  
Dai Akine ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Vertebral Osteomyelitis ◽  
Resonance Imaging ◽  
Repeat Magnetic Resonance Imaging

scholarly journals Is There an Association Between Magnetic Resonance Imaging and Neurological Signs in Patients With Vertebral Osteomyelitis?

Medicine ◽  
2016 ◽  
Vol 95 (3) ◽  
pp. e2373 ◽  
Author(s):  
Géraldine Bart ◽  
Hervé Redon ◽  
David Boutoille ◽  
Olivier Hamel ◽  
Lucie Planche ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Vertebral Osteomyelitis ◽  
Resonance Imaging ◽  
Neurological Signs

scholarly journals Dabigatran following acute transient ischemic attack and minor stroke II (DATAS II)

2017 ◽  
Vol 12 (8) ◽  
pp. 910-914 ◽  
Author(s):  
Kuan H Ng ◽  
Mukul Sharma ◽  
Oscar Benavente ◽  
Laura Gioia ◽  
Thalia S Field ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Ischemic Stroke ◽  
Magnetic Resonance ◽  
Transient Ischemic Attack ◽  
Hemorrhagic Transformation ◽  
Phase Iii ◽  
Minor Stroke ◽  
Resonance Imaging ◽  
Repeat Magnetic Resonance Imaging ◽  
Ischemic Attack

Rationale Patients with transient ischemic attack or minor stroke are at high risk of early recurrent cerebrovascular events. Anticoagulation with heparin or warfarin acutely after ischemic stroke is at least as efficacious as aspirin for preventing recurrent events but is associated with an increased risk of clinical worsening due to hemorrhagic transformation. Aim and hypothesis We aim to demonstrate the safety of early anticoagulation with dabigatran, an oral direct thrombin inhibitor, in acute cerebrovascular syndrome patients. The primary hypothesis is that symptomatic hemorrhagic transformation rates in dabigatran and aspirin-treated patients will be similar. Sample size estimates At least 136 participants in two groups required to demonstrate an absolute between-group difference in the rate of hemorrhagic transformation of 5.6% with 80% power, assuming alpha = 5%. Methods and design A randomized, multicenter open-label clinical trial (NCT02295826). Three-hundred participants with a transient ischemic attack/ischemic stroke (National Institutes of Health Stroke Scale ≤ 9) will undergo magnetic resonance imaging within 72 h of symptom onset and will be randomized to aspirin 81 mg daily or dabigatran 150 mg twice daily for 30 days. Participants undergo repeat magnetic resonance imaging at 30 days and clinical assessment to 90 days. Study outcomes The primary outcome is the symptomatic hemorrhagic transformation rate. Secondary outcomes include recurrent stroke and new ischemic lesions on repeat magnetic resonance imaging. Discussion This study will determine the safety of early anticoagulation with dabigatran in patients with acute transient ischemic attack/ischemic stroke and will inform the design of a phase III randomized trial aimed at demonstrating reduced recurrent early ischemic events after acute transient ischemic attack/stroke.

scholarly journals Isolated Bilateral Gastrocnemius Myositis in Crohn Disease Successfully Treated with Adalimumab

2016 ◽  
Vol 10 (3) ◽  
pp. 661-667 ◽  
Author(s):  
Salvatore Vadala di Prampero ◽  
Marco Marino ◽  
Francesco Toso ◽  
Claudio Avellini ◽  
Vu Nguyen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Crohn Disease ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Resonance Imaging ◽  
Extraintestinal Manifestation ◽  
Repeat Magnetic Resonance Imaging ◽  
Vein Thrombosis ◽  
First Case ◽  
High Intensity Signal

Extraintestinal manifestations are common in inflammatory bowel disease; however, muscular involvement in Crohn disease is rarely reported. We present a case of a 26-year-old male with ileocolonic Crohn disease who developed sudden tenderness in both calves. Doppler ultrasound was negative for deep vein thrombosis. Magnetic resonance imaging of the gastrocnemius muscle showed high intensity signal in the muscle fibers, and muscle biopsy demonstrated nonspecific lymphocytic myositis. Other relevant laboratory results included normal antineutrophil cytoplasmic antibodies and creatine kinase as well as elevated C-reactive protein, erythrocyte sedimentation rate, and anti-Saccharomyces cerevisiae IgG titer. The patient was in clinical remission, being treated with azathioprine 2.5 mg/kg. Prednisone 60 mg/day was initiated with rapid resolution of calf tenderness; however, tenderness soon returned when the dose was tapered to 10 mg/day. Subsequently, prednisone and azathioprine were discontinued, and adalimumab was started at standard induction and maintenance doses. The patient’s symptoms resolved shortly after the first induction dose. A repeat magnetic resonance imaging of the calves – 3 months after starting adalimumab – showed complete resolution of muscle inflammation. To our knowledge, this is the first case of gastrocnemius myositis – a rare extraintestinal manifestation of Crohn disease – successfully treated with anti-tumor necrosis factor agents.

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