Young people’s experiences of a CDH1 pathogenic variant: Decision‐making about gastric cancer risk management

2021 ◽  
Author(s):  
Cass Hoskins ◽  
Erin Tutty ◽  
Rebecca Purvis ◽  
Mary Shanahan ◽  
Alex Boussioutas ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Decision Making ◽  
Risk Management ◽  
Cancer Risk ◽  
Pathogenic Variant ◽  
Gastric Cancer Risk ◽  
Cancer Risk Management

The influence of BRCA variants of uncertain significance in cancer risk management decision-making.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 1555-1555
Author(s):  
Jing-Yi Chern ◽  
Sarah S. Lee ◽  
Melissa K Frey ◽  
Rebecca Bassett ◽  
Jessica Martineau ◽  
...  
Keyword(s):  
Decision Making ◽  
Risk Management ◽  
Cancer Risk ◽  
Management Decision ◽  
Variants Of Uncertain Significance ◽  
Uncertain Significance ◽  
Management Decision Making ◽  
Cancer Risk Management

scholarly journals A Microsimulation Model for Evaluating the Effectiveness of Cancer Risk Management for BRCA Pathogenic Variant Carriers: miBRovaCAre

2019 ◽  
Vol 22 (8) ◽  
pp. 854-862 ◽  
Author(s):  
Lara Petelin ◽  
Lucinda Hossack ◽  
Gillian Mitchell ◽  
Danny Liew ◽  
Alison H. Trainer ◽  
...  
Keyword(s):  
Risk Management ◽  
Cancer Risk ◽  
Pathogenic Variant ◽  
Microsimulation Model ◽  
Cancer Risk Management

scholarly journals Patient-Reported Outcome Measures may optimize shared decision-making for cancer risk management in BRCA mutation carriers

Breast Cancer ◽  
2019 ◽  
Vol 27 (3) ◽  
pp. 426-434
Author(s):  
L. S. E. van Egdom ◽  
M. A. de Kock ◽  
I. Apon ◽  
M. A. M. Mureau ◽  
C. Verhoef ◽  
...  
Keyword(s):  
Decision Making ◽  
Risk Management ◽  
Cancer Risk ◽  
Shared Decision Making ◽  
Well Being ◽  
Shared Decision ◽  
Mutation Carriers ◽  
Patient Reported ◽  
One Year ◽  
Cancer Risk Management

Abstract Purpose The aim of this study was to compare patient-reported outcomes (PROs) of BRCA1/2 mutation carriers, either after bilateral prophylactic mastectomy (BPM) or during breast surveillance, to improve shared decision-making in their cancer risk management. Methods Unaffected BRCA1/2 mutation carriers at least one year after BPM followed by immediate breast reconstruction (BPM-IBR) or one year under surveillance were eligible. After informed consent, the Hospital Anxiety and Depression Scale (HADS) and BREAST-Q were administered and compared between the different strategies. PROs were also compared to available normative data. Results Ninety-six participants were analyzed in this study and showed significant differences between strategies in age, age at genetic testing, and time since BPM or starting breast surveillance. All HADS scores were below 8 suggesting no signs of anxiety or depression in both groups. Higher mean ‘Q-physical well-being’ scores were reported by the surveillance group (81.78 [CI 76.99–86.57]) than the BPM group (76.96 [CI 73.16 – 80.75]; p = 0.011). Overall, for both questionnaires better scores were seen when compared to age-matched normative data. Conclusions No signs of anxiety or depression were seen in the surveillance or BPM-IBR group. Slightly better mean BREAST-Q scores were seen for the surveillance group in comparison to BPM-IBR, except for ‘Q-psychological well-being’. The difference in ‘Q-physical well-being’ was significantly worse for BPM-IBR. Approaches to obtain longitudinal PROs and reference values should be explored in the future, which could add value to shared decision-making in regards to breast cancer risk management in this specific patient population.

Histopathology of Helicobacter pylori associated gastritis in children from high-and low-gastric cancer risk populations

2001 ◽  
Vol 120 (5) ◽  
pp. A657-A657
Author(s):  
A BEDOYA ◽  
J GARAY ◽  
F SANZON ◽  
J BRAVO ◽  
H CORREA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Cancer Risk ◽  
Gastric Cancer Risk

IL-1beta and IL-10 genotypes in a high gastric cancer risk province in China

2001 ◽  
Vol 120 (5) ◽  
pp. A743-A743
Author(s):  
E ELOMAR ◽  
W YOU ◽  
W CHOW ◽  
J FRAUMENIJR ◽  
C RABKIN
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Gastric Cancer Risk
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