Galanin and its binding sites in the brain of eels subjected to different osmolar conditions

2006 ◽  
Vol 305A (10) ◽  
pp. 862-871 ◽  
Author(s):  
Maria Angela Masini ◽  
Paola Prato ◽  
Bianca Maria Uva
Keyword(s):  
Binding Sites ◽  
The Brain

Autoradiographic analysis of 5-HT2A binding sites in the brain of Sardinian alcohol-preferring and nonpreferring rats

1999 ◽  
Vol 373 (1) ◽  
pp. 13-19 ◽  
Author(s):  
Roberto Ciccocioppo ◽  
Stefania Angeletti ◽  
Giancarlo Colombo ◽  
GianLuigi Gessa ◽  
Maurizio Massi
Keyword(s):  
Binding Sites ◽  
Autoradiographic Analysis ◽  
The Brain

Distribution and characterisation of somatostatin receptor mRNA and binding sites in the brain and periphery

2000 ◽  
Vol 94 (3-4) ◽  
pp. 265-281 ◽  
Author(s):  
Dominique Fehlmann ◽  
Daniel Langenegger ◽  
Edy Schuepbach ◽  
Sandra Siehler ◽  
Dominik Feuerbach ◽  
...  
Keyword(s):  
Binding Sites ◽  
Somatostatin Receptor ◽  
Receptor Mrna ◽  
The Brain

Serotonin binding sites and metabolites in the brain of schizophrenic suicide victims

1991 ◽  
Vol 4 (3) ◽  
pp. 376-377
Author(s):  
R. Conley ◽  
R. Schmitt ◽  
G.-S. Pandy ◽  
F. Peretti ◽  
J. Smialek ◽  
...  
Keyword(s):  
Binding Sites ◽  
The Brain

Localization of binding sites for oxytocin in the brain of the golden hamster

Neuroreport ◽  
1992 ◽  
Vol 3 (9) ◽  
pp. 797-800 ◽  
Author(s):  
Michel Dubois-Dauphin ◽  
Paul Pévet ◽  
Claude Barberis ◽  
Eliane Tribollet ◽  
Jean Jacques Dreifuss
Keyword(s):  
Golden Hamster ◽  
Binding Sites ◽  
The Brain

Localization of stable prostaglandin (PG) I2 agonist binding sites and possible role of PGI2 in the brain

1991 ◽  
Vol 16 ◽  
pp. 21
Author(s):  
Yasuyoshi Watanabe ◽  
Yumiko Watanabe ◽  
Kiyoshi Matsumura ◽  
Hirotaka Onoe ◽  
Nobuko Mataga
Keyword(s):  
Binding Sites ◽  
Agonist Binding ◽  
The Brain

Kernicterus in Rats with an Inherited Deficiency of Glucuronyal Transferase

PEDIATRICS ◽  
1959 ◽  
Vol 24 (1) ◽  
pp. 73-73
Keyword(s):  
Binding Sites ◽  
Renal Excretion ◽  
Practical Importance ◽  
Human Beings ◽  
Human Infants ◽  
Toxic Agent ◽  
History Of ◽  
The Central Nervous System ◽  
The Brain ◽  
Comprehensive Study

Aside from the great theoretic interest, the experiments described in this paper have considerable practical importance in providing a means of studying the efficacy of treatments designed to prevent kernicterus. A comprehensive study of a strain of rats (the Gunn strain) which have a hereditary deficiency of the enzyme required to conjugate bilirubin, and thus develope jaundice due to increased concentration of unconjugated bilirubin in the blood and tissues. The rats developed kernicterus which was apparently identical with that seen in human beings and is the only example of kernicterus in animals that fulfills rigid criteria outlined by the authors. Extensive data on the natural history of the bilirubinemia and development of kernicterus in the rats, as determined by chemical and pathologic techniques, are provided. Bilirubin itself is incriminated as the toxic agent producing the characteristic changes in the brain in kernicterus. Sulfonamides were found to augment the toxic effects of bilirubin, apparently because of competition between bilirubin and sulfonamides for binding sites on serum albumin. Neither infection nor hypoxia appeared to aggravate the effects of bilirubin. Administration of sodium glucuronate to jaundiced rats was followed by a decrease in bilirubin in the serum which at times exceeded 50%. This was not accompanied by any postponement of the onset of signs of damage to the central nervous system and did not prevent development of kernicterus. It appeared that the decrease in bilirubin in the serum may have resulted from an increased transferral to tissues rather than elimination through renal excretion. On the basis of the knowledge of this strain of rats, it should be possible to explore the usefulness of proposed therapeutic regimens in the experimental animal without jeopardizing the course of human infants who might be successfully treated with exchange transfusion pending the discovery of a more satisfactory therapy.

Visualization of Neurokinin, Growth Factor, Ion Channel and Second Messenger Binding Sites in the Brain: Clues to their Function

1989 ◽  
pp. 73-85
Author(s):  
Rémi Quirion ◽  
Dalia M. Araujo ◽  
Than Vinh Dam ◽  
Michel Dalpé ◽  
Jean-Guy Chabot
Keyword(s):  
Growth Factor ◽  
Ion Channel ◽  
Binding Sites ◽  
Second Messenger ◽  
The Brain
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