Thyroid status affects membranes susceptibility to free radicals and oxidative balance in skeletal muscle of Muscovy ducklings (Cairina moschata)

2014 ◽  
Vol 321 (8) ◽  
pp. 415-421 ◽  
Author(s):  
Benjamin Rey ◽  
Caroline Romestaing ◽  
Jacques Bodennec ◽  
Adeline Dumet ◽  
Anaïs Fongy ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Free Radicals ◽  
Thyroid Status ◽  
Oxidative Balance ◽  
Cairina Moschata

Properties of 5′-deiodinase of 3,3′,5′-triiodothyronine in rat skeletal muscle

1989 ◽  
Vol 120 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Fujiko Tsukahara ◽  
Teruko Nomoto ◽  
Michiko Maeda
Keyword(s):  
Skeletal Muscle ◽  
Drinking Water ◽  
Incubation Medium ◽  
Marked Reduction ◽  
Daily Administration ◽  
Type I ◽  
Rat Skeletal Muscle ◽  
Thyroid Status ◽  
Altered Thyroid

Abstract. To characterize rT3 5′-deiodinase (5′D) in rat skeletal muscle, the effects of altered thyroid status and PTU on rT3 5′D were studied. rT3 5′D activity was measured by incubating homogenates of rat skeletal muscle with [125]rT3, iodine labelled in the outer ring, in the presence of 20 mmol/l DL-dithiothreitol. This activity was observed to increase significantly 24 h after a single sc injection of T3 (75 μg/kg). The increase following the daily administration of this drug (15 or 75 μg/kg) for 3 and 14 days was dependent on the dose and number of previous days of injection. A significant decrease in activity was observed 2 weeks after thyroidectomy. The addition of 0.1 mmol/l 6-n-propyl-2-thiouracil (PTU) to the incubation medium in vitro caused a marked reduction in the activity in homogenates of skeletal muscle from hypothyroid, euthyroid and hyperthyroid rats. PTU, present at 0.05% in the drinking water for 2 weeks virtually abolished it. The properties of rT3 5′D in rat skeletal muscle thus appear to be essentially the same as those of type I enzyme with respect to response toward altered thyroid status and PTU.

MRI imaging for in vivo free radicals and bioenergetics in mouse skeletal muscle

2018 ◽  
Vol 128 ◽  
pp. S123
Author(s):  
Bumsoo Ahn ◽  
Nataliya Smith ◽  
Debra Saunders ◽  
Holly Van Remmen ◽  
Rheal Towner
Keyword(s):  
Skeletal Muscle ◽  
Free Radicals ◽  
Mri Imaging ◽  
Mouse Skeletal Muscle

scholarly journals Effects of hyperthyroidism and hypothyroidism on glutamine metabolism by skeletal muscle of the rat

1990 ◽  
Vol 272 (2) ◽  
pp. 319-322 ◽  
Author(s):  
M Parry-Billings ◽  
G D Dimitriadis ◽  
B Leighton ◽  
J Bond ◽  
S J Bevan ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Amino Acids ◽  
Soleus Muscle ◽  
Gastrocnemius Muscle ◽  
Glutamine Metabolism ◽  
Thyroid Status ◽  
Pathological Conditions ◽  
Per Se

1. The effects of hyperthyroidism and hypothyroidism on the concentrations of glutamine and other amino acids in the muscle and plasma and on the rates of glutamine and alanine release from incubated isolated stripped soleus muscle of the rat were investigated. 2. Hyperthyroidism decreased the concentration of glutamine in soleus muscle but was without effect on that in the gastrocnemius muscle or in the plasma. Hyperthyroidism also increased markedly the rate of release of glutamine from the incubated soleus muscle. 3. Hypothyroidism decreased the concentrations of glutamine in the gastrocnemius muscle and plasma but was without effect on that in soleus muscle. Hypothyroidism also decreased markedly the rate of glutamine release from the incubated soleus muscle. 4. Thyroid status was found to have marked effects on the rate of glutamine release by skeletal muscle per se, and may be important in the control of this process in both physiological and pathological conditions.

Perinatal ontogeny of porcine growth hormone receptor gene expression is modulated by thyroid status

1996 ◽  
Vol 134 (4) ◽  
pp. 524-531 ◽  
Author(s):  
C Duchamp ◽  
KA Burton ◽  
P Herpin ◽  
MJ Dauncey
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Growth Hormone ◽  
Growth Hormone Receptor ◽  
Receptor Gene ◽  
Thyroid Status ◽  
Ghr Gene ◽  
Growth Hormone Receptor Gene ◽  
Receptor Gene Expression ◽  
Hormone Receptor Gene

Duchamp C, Burton KA, Herpin P, Dauncey MJ, Perinatal ontogeny of porcine growth hormone receptor gene expression is modulated by thyroid status. Eur J Endocrinol 1996;134:524–31 The ontogeny of growth hormone receptors (GHR) represents a critical stage in growth and metabolism. We have investigated the perinatal ontogeny of hepatic and skeletal muscle GHR gene expression in piglets, and its modulation by GH and thyroid hormones. Test piglets were rendered hypothyroid in late gestation by feeding the sow a high-glucosinolate rapeseed meal. Plasma and tissue samples were obtained from test and control piglets at various ages between 80 days of fetal life (80F) and 2 days postnatally. Plasma hormone levels were determined by radioimmunoassay and GHR mRNA by RNase protection assays. In controls, plasma thyroxine (T4) and 3,5,3′-triiodothyronine (T3) levels increased between 80F and birth and the early postnatal period was characterized by a marked surge in plasma T3. Test piglets were hypothyroid at 110F with total T4, total T3 and free T3 levels being reduced by 28, 53 and 33% respectively. By contrast, the postnatal increase in T3 was more marked in test than in control animals. Plasma GH levels decreased over the perinatal period and there was no effect of treatment. Hepatic GHR mRNA was at the lower limit of detection at 80F but by 11 OF was expressed in both groups of animals. However, fetal hypothyroidism at 11 OF resulted in a marked 70% decrease in hepatic GHR mRNA (p < 0.01). The higher postnatal rise in T3 in test piglets was accompanied by a recovery of hepatic GHR mRNA levels. By contrast with liver, skeletal muscle (longissimus dorsi) expressed high levels of GHR mRNA at 80F and hypothyroidism induced a 68% increase in GHR mRNA (p < 0.001). The present results suggest that thyroid hormones may modulate the perinatal ontogeny of GHR gene expression, in addition to other hormonal factors, and that this modulation is tissue-specific. MJ Dauncey, Department of Cellular Physiology, The Babraham Institute, Cambridge CB2 4AT, UK

scholarly journals Effect of Thyroid Status on Insulin Action in Rat Adipocytes and Skeletal Muscle

1980 ◽  
Vol 66 (3) ◽  
pp. 574-582 ◽  
Author(s):  
Michael P. Czech ◽  
Craig C. Malbon ◽  
Keith Kerman ◽  
Wendy Gitomer ◽  
Paul F. Pilch
Keyword(s):  
Skeletal Muscle ◽  
Insulin Action ◽  
Thyroid Status ◽  
Rat Adipocytes

scholarly journals Skeletal muscle ischemia and reperfusion in rats increase lipid peroxidation in rats

2004 ◽  
Vol 19 (5) ◽  
pp. 578-581 ◽  
Author(s):  
Carlos Eli Piccinato ◽  
Armando De Domenico Jr ◽  
Alceu Afonso Jordão Jr ◽  
Helio Vannucchi
Keyword(s):  
Skeletal Muscle ◽  
Lipid Peroxidation ◽  
Free Radicals ◽  
Vitamin E ◽  
Ischemia Reperfusion ◽  
Ischemia And Reperfusion ◽  
Muscle Ischemia ◽  
Increase Lipid Peroxidation ◽  
Deficient Group

PURPOSE: To determine the effects of 30 minutes of ischemia followed by 30 minutes of reperfusion in skeletal muscle of rats receiving three different diets (supplemented, normal and vitamin E deficient) on lipoperoxidation (LP). METHODS: LP measured by TBARS levels, and plasma and hepatic concentrations of vitamin E measured by HPLC. RESULTS: The deficient group presented higher lipoperoxidation levels in muscle compared to the control and supplemented groups. CONCLUSION: Supplementation with vitamin E decrease the free radicals production in ischemia/reperfusion in skeletal muscle of rats.

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