Computerized morphometry analysis of epithelial fimbriae nuclear symmetry in BRCA carriers may identify patients at risk for developing ovarian cancer

2021 ◽  
Author(s):  
Amnon Amit ◽  
Edmond Sabo ◽  
Anna Petruseva ◽  
Leah Stroller ◽  
Ari Reiss ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
At Risk ◽  
Computerized Morphometry ◽  
Morphometry Analysis ◽  
Patients At Risk ◽  
Brca Carriers

Genetic counseling and cancer risk perception in Brazilian patients at-risk for hereditary breast and ovarian cancer

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 9698-9698 ◽  
Author(s):  
E. I. Palmero ◽  
M. Caleffi ◽  
F. R. Vargas ◽  
J. C. C. Rocha ◽  
R. Giugliani ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
At Risk ◽  
Genetic Counseling ◽  
Risk Perception ◽  
Cancer Risk ◽  
Breast And Ovarian Cancer ◽  
Cancer Risk Perception ◽  
Patients At Risk

Genetic counseling and cancer risk perception in Brazilian patients at-risk for hereditary breast and ovarian cancer

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 9698-9698
Author(s):  
E. I. Palmero ◽  
M. Caleffi ◽  
F. R. Vargas ◽  
J. C. C. Rocha ◽  
R. Giugliani ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
At Risk ◽  
Genetic Counseling ◽  
Risk Perception ◽  
Cancer Risk ◽  
Breast And Ovarian Cancer ◽  
Cancer Risk Perception ◽  
Patients At Risk

Implementing a Screening Tool for Identifying Patients at Risk for Hereditary Breast and Ovarian Cancer: A Statewide Initiative

2014 ◽  
Vol 21 (10) ◽  
pp. 3342-3347 ◽  
Author(s):  
L. Brannon Traxler ◽  
Monique L. Martin ◽  
Alice S. Kerber ◽  
Cecelia A. Bellcross ◽  
Barbara E. Crane ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
At Risk ◽  
Screening Tool ◽  
Breast And Ovarian Cancer ◽  
Patients At Risk

A comparison of ovarian cancer treatments: analysis of utility assessments of ovarian cancer patients, at-risk population, general population, and physicians

2004 ◽  
Vol 93 (1) ◽  
pp. 164-169 ◽  
Author(s):  
Elizabeth A Calhoun ◽  
David A Fishman ◽  
John R Lurain ◽  
Emily E Welshman ◽  
Charles L Bennett
Keyword(s):  
Ovarian Cancer ◽  
At Risk ◽  
General Population ◽  
Cancer Patients ◽  
Cancer Treatments ◽  
Risk Population ◽  
Patients At Risk

scholarly journals Breadth of Genetic Testing Selected by Patients at Risk of Hereditary Breast and Ovarian Cancer

2018 ◽  
Vol 28 (1) ◽  
pp. 26-33 ◽  
Author(s):  
J. Brian Szender ◽  
Jasmine Kaur ◽  
Katherine Clayback ◽  
Mollie L. Hutton ◽  
June Mikkelson ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
At Risk ◽  
Genetic Counseling ◽  
Genetic Testing ◽  
Confidence Interval ◽  
Categorical Variables ◽  
Breast And Ovarian Cancer ◽  
Clinical Genetic ◽  
Patients At Risk ◽  
The Impact

ObjectiveThe aim of this study was to evaluate the ability of patients at risk of hereditary breast and ovarian cancer (HBOC) syndrome to select the extent of genetic testing personally preferred and the impact of demographic factors on the breadth of testing pursued.MethodsA single-institution cohort was enumerated consisting of patients referred for clinical genetic counseling secondary to risk of HBOC syndrome. This was a retrospective study of consecutive patients seen for genetic counseling; all patients completed an epidemiologic questionnaire and provided personal and family medical histories. Patients meeting guidelines for testing were offered testing at 3 levels: single gene/condition (Single), small panels with highly penetrant genes (Plus), and large panels with high and moderately penetrant genes (Next). Associations between personal or family-related factors and breadth of testing selected were investigated. Continuous and categorical variables were compared using Student t and χ2 tests, as appropriate. Joint classification tables were used to test for effect modification, and a log-binomial model was used to compute rate ratios (RR) with a threshold of P < 0.05 considered significant.ResultsWe identified 253 patients who underwent genetic counseling for HBOC syndrome. Most patients were personally affected by cancer (63.6%), reported at least some college (79.2%), met the National Comprehensive Cancer Network guidelines for BRCA testing (94.5%), and opted to undergo genetic testing (94.1%). Most (84.9%) patients opted for panel testing. An increased likelihood of choosing Next-level testing was found to be associated with patients having any college experience (RR, 1.53; 95% confidence interval, 1.02–2.30), as well as being unaffected by cancer (RR, 1.30; 95% confidence interval, 1.03–1.64).ConclusionsClinical genetic counseling is a highly specialized service, which should be provided to patients at risk of hereditary cancer syndromes. Although some epidemiologic factors can predict a patient's preference for testing breadth, patients were sufficiently able to self-identify the level of testing they were comfortable with after receiving genetic counseling. Most practitioners do not have the time or expertise to provide the degree of counseling needed to enable and empower patients to choose the level of testing they are comfortable with. When available, referral to genetic counselors remains an important component of comprehensive care for women with a personal or family history of cancer suggestive of hereditary risk.

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