Uncommon hepatic macrophagic foamy‐cell nodules in Iberian barbel ( Lucio barbus bocagei Steindachner, 1864) from the Vizela River (Portugal)

2019 ◽  
Vol 82 (7) ◽  
pp. 1127-1135 ◽  
Author(s):  
João S. Carrola ◽  
António Fontainhas‐Fernandes ◽  
Eduardo Rocha
Keyword(s):  
Author(s):  
Marián Švajdler ◽  
Marián Benický ◽  
Lucia Fröhlichová ◽  
Tomáš Beneš ◽  
Zuzana Hojstričová ◽  
...  

2010 ◽  
Vol 37 (8) ◽  
pp. 901-906 ◽  
Author(s):  
Amy D. Tatsas ◽  
Vicki L. Keedy ◽  
Scott R. Florell ◽  
Jean F. Simpson ◽  
Cheryl M. Coffin ◽  
...  
Keyword(s):  

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi156-vi156
Author(s):  
Tokunori Kanazawa ◽  
Kentaro Ohara ◽  
Kazunari Yoshida ◽  
Hikaru Sasaki

Abstract BACKGROUND Little is known about histopathological changes after chemotherapy in lower-grade gliomas (LrGGs). METHODS We investigated 15 1p/19q-codeleted gliomas resected following tumor volume decrease after alkylating agents chemotherapy in comparison with their pre-chemotherapy specimens. Histopathological changes by chemotherapy were evaluated by hematoxilyn-eosin staining and immunohistochemistry for Ki-67/MIB-1, CD68 as pan macrophage/monocyte marker, CD163 as presumed marker of M2 polarity, and nestin and CD133 as markers of glioma stem cells (GSCs). RESULTS Histologically, there were several presumed chemotherapy-related changes in the post-chemotherapy specimens, with the most frequent findings being sparse glial background and abundant foamy cell infiltration. The Ki-67/MIB-1 indices significantly decreased, and CD68+ cells significantly increased after chemotherapy. The increasing rate of CD68+ cells in the post-/pre-chemotherapy specimens was prone to be associated with patients’ progression-free survival (PFS) and overall survival (OS), but not tumor response. The number of CD163+ cells and the ratio of nestin+ cells and CD133+ cells significantly increased after chemotherapy. The number of CD163+ cells, the ratio of nestin+ cells and CD133+ cells, and M2 (CD163+)/M1+M2 (CD68+) ratio in the post-chemotherapy specimens were negatively correlated with patients’ PFS and OS. There was no difference between chemotherapy regimens (temozolomide versus nitrosourea-based) in the number of CD163+ cells and the ratio of nestin+ and CD133+ cells. CONCLUSIONS GSCs in conjunction with M2 macrophages constitute the mechanism of resistance to and recurrence after alkylating agents chemotherapy in LrGGs.


2002 ◽  
Vol 41 (4) ◽  
pp. 369-371 ◽  
Author(s):  
A Cavazza ◽  
G Pasquinelli ◽  
L Agostini ◽  
KO Leslie ◽  
TV Colby
Keyword(s):  

1986 ◽  
Vol 36 (12) ◽  
pp. 1863-1869
Author(s):  
Tokuhiro Ishihaea ◽  
Noboru Matsumoto ◽  
Yoshiko Okuzono ◽  
Yoshimi Yamashita ◽  
Takaaki Nagasawa ◽  
...  

1996 ◽  
Vol 29 (3) ◽  
pp. 271-274 ◽  
Author(s):  
S. MATSUKUMA ◽  
K. SUDA

2013 ◽  
Vol 8 (1) ◽  
Author(s):  
Simona Stolnicu ◽  
Enoe Quiñonez ◽  
Monica Boros ◽  
Claudiu Molnar ◽  
Isabel Dulcey ◽  
...  
Keyword(s):  

2014 ◽  
Vol 465 (2) ◽  
pp. 215-224 ◽  
Author(s):  
Fredrik Petersson ◽  
Maris Sperga ◽  
Stela Bulimbasic ◽  
Petr Martinek ◽  
Marian Svajdler ◽  
...  

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