Ethanol exposure during peripubertal period increases the mast cell number and impairs meiotic and spermatic parameters in adult male rats

2016 ◽  
Vol 79 (6) ◽  
pp. 541-549 ◽  
Author(s):  
Ana Paula Franco Punhagui ◽  
Henrique Rodrigues Vieira ◽  
Gláucia Eloisa Munhoz De Lion Siervo ◽  
Renata da Rosa ◽  
Glaura Scantamburlo Alves Fernandes
Keyword(s):  
Mast Cell ◽  
Adult Male ◽  
Cell Number ◽  
Ethanol Exposure ◽  
Male Rats ◽  
Mast Cell Number

scholarly journals Mast Cells in the Developing Brain Determine Adult Sexual Behavior

2017 ◽  
Author(s):  
Kathryn M. Lenz ◽  
Lindsay A. Pickett ◽  
Christopher L. Wright ◽  
Katherine T. Davis ◽  
Anabel Galan ◽  
...  
Keyword(s):  
Mast Cell ◽  
Sex Differences ◽  
Mast Cells ◽  
Copulatory Behavior ◽  
Cell Number ◽  
Gonadal Hormones ◽  
Male Rats ◽  
Sex Behavior ◽  
Mast Cell Number ◽  
Brain And Behavior

AbstractSex differences in brain and behavior are programmed during development by gonadal hormones. We found that the immune system-derived mast cell is a primary target for the masculinizing hormone, estradiol. Male rats had more mast cells in the preoptic area (POA), a brain region essential for male copulatory behavior, during the critical period for sexual differentiation. Activating mast cells in females masculinized POA neuronal and microglial morphology and adult sex behavior, and inhibiting mast cells in males blunted masculinization. Estradiol increased mast cell number and caused mast cells to release histamine, which stimulated microglia to release prostaglandins and thereby induced male-typical synaptic patterning. Inducing an allergic reaction in pregnant dams increased mast cell number in the brains of female fetuses and masculinized neuronal and microglia morphology and adult copulatory behavior. These findings identify a novel non-neuronal origin of brain sex differences and non-steroidal source of variability in brain feminization.

scholarly journals GPR30 decreases cardiac chymase/angiotensin II by inhibiting local mast cell number

2015 ◽  
Vol 459 (1) ◽  
pp. 131-136 ◽  
Author(s):  
Zhuo Zhao ◽  
Hao Wang ◽  
Marina Lin ◽  
Leanne Groban
Keyword(s):  
Mast Cell ◽  
Angiotensin Ii ◽  
Cell Number ◽  
Mast Cell Number

The expulsion of Echinostoma trivolvis: worm kinetics and intestinal cytopathology in conventional and congenitally athymic BALB/c mice

Parasitology ◽  
1993 ◽  
Vol 106 (3) ◽  
pp. 297-304 ◽  
Author(s):  
T. Fujino ◽  
B. Fried ◽  
I. Tada
Keyword(s):  
Mast Cell ◽  
Goblet Cells ◽  
Cell Number ◽  
Athymic Mice ◽  
Post Exposure ◽  
Mucosal Mast Cells ◽  
Worm Recovery ◽  
Mast Cell Number ◽  
Echinostoma Trivolvis ◽  
Over Time

SUMMARYThe infectivity and distribution of Echinostoma trivolvis were studied in male, conventional and congenitally athymic nude mice, each infected with 30 metacercarial cysts. In conventional mice, worm recoveries at 6 and 8 days post-exposure were58·3 and 54·0%, respectively. Worm recovery declined to 44·0% by day 10, to 4·3% by day 13, and 0% by day 17. In athymic mice, worm recoveries at 6 and 8 days post-exposure were 61·7 and 36·3%, respectively. Worm recovery declined to 27·7% by day 10, to 0·7% by day 13, and 0% by day 17. The distribution of worms demonstrated a posteriad migration over time in both groups. Kinetic changes in the number of goblet and mucosal mast cells in the upper ileum of mice infected with E. trivolvis were examined. In conventional mice, the number of goblet cells increased rapidly to reach a peak at day 13 and then declined gradually. The number of goblet cells in athymic mice also increased to reach a peak at day 13, and then declined rapidly. However, the number of goblet cells in athymic mice was always less than that inconventional mice. The mast cell number in infected conventional mice increased rapidly to reach a peak at day 17 and then declined. There was no increase in the mast cell number of infected athymic mice throughout the experiment. Whereas common pathological changes occurred in the intestines of both mice groups infected with echinostomes some ultrastructural differences were observed in the gut epithelial cells of conventional versus athymic mice.

Altered hippocampal neurogenesis in adult male rats after prenatal ethanol exposure

2006 ◽  
Vol 27 (1) ◽  
pp. 100-101 ◽  
Author(s):  
Joanna H. Sliwowska ◽  
Jennifer M. Barker ◽  
Cindy Barha ◽  
Linda Ellis ◽  
Wayne Yu ◽  
...  
Keyword(s):  
Adult Male ◽  
Ethanol Exposure ◽  
Hippocampal Neurogenesis ◽  
Male Rats ◽  
Prenatal Ethanol Exposure

The effects of gonadectomy and binge-like ethanol exposure during adolescence on open field behaviour in adult male rats

2015 ◽  
Vol 604 ◽  
pp. 52-57 ◽  
Author(s):  
Wensheng Yan ◽  
Jie Kang ◽  
Guoliang Zhang ◽  
Shuangcheng Li ◽  
Yunxiao Kang ◽  
...  
Keyword(s):  
Open Field ◽  
Adult Male ◽  
Ethanol Exposure ◽  
Male Rats ◽  
Field Behaviour ◽  
Open Field Behaviour

Mast Cell Chymase Regulates Dermal Mast Cell Number in Mice

2002 ◽  
Vol 290 (5) ◽  
pp. 1478-1482 ◽  
Author(s):  
Yoshiaki Tomimori ◽  
Tsuyoshi Muto ◽  
Harukazu Fukami ◽  
Kayo Saito ◽  
Chika Horikawa ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Number ◽  
Mast Cell Number ◽  
Mast Cell Chymase

Human testicular mast cells contain tryptase: increased mast cell number and altered distribution in the testes of infertile men

2000 ◽  
Vol 74 (2) ◽  
pp. 239-244 ◽  
Author(s):  
Viktor Meineke ◽  
Monica B Frungieri ◽  
Berthold Jessberger ◽  
Hermann-Josef Vogt ◽  
Artur Mayerhofer
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Cell Number ◽  
Infertile Men ◽  
Mast Cell Number
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