C1q, the classical complement pathway protein binds Hirano bodies in Pick's disease

2013 ◽  
Vol 76 (6) ◽  
pp. 606-611 ◽  
Author(s):  
Sim K. Singhrao
Keyword(s):  
Pick's Disease ◽  
Pick’S Disease ◽  
Complement Pathway ◽  
Hirano Bodies ◽  
Classical Complement Pathway ◽  
Classical Complement

scholarly journals Carbamylation of immunoglobulin abrogates activation of the classical complement pathway

2014 ◽  
Vol 44 (11) ◽  
pp. 3403-3412 ◽  
Author(s):  
Catalin Koro ◽  
Ewa Bielecka ◽  
Anders Dahl‐Knudsen ◽  
Jan J. Enghild ◽  
Carsten Scavenius ◽  
...  
Keyword(s):  
Complement Pathway ◽  
Classical Complement Pathway ◽  
Classical Complement

scholarly journals Herpes Simplex Virus Type 1 and 2 Glycoprotein C Prevents Complement-Mediated Neutralization Induced by Natural Immunoglobulin M Antibody

2006 ◽  
Vol 80 (8) ◽  
pp. 4038-4046 ◽  
Author(s):  
Lauren M. Hook ◽  
John M. Lubinski ◽  
Ming Jiang ◽  
Michael K. Pangburn ◽  
Harvey M. Friedman
Keyword(s):  
Herpes Simplex ◽  
Human Serum ◽  
Immunoglobulin M ◽  
Complement Pathway ◽  
Glycoprotein C ◽  
Classical Complement Pathway ◽  
Simplex Virus ◽  
Classical Complement ◽  
Hsv 1

ABSTRACT Glycoprotein C (gC) of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) binds complement component C3b and protects virus from complement-mediated neutralization. Differences in complement interacting domains exist between gC of HSV-1 (gC1) and HSV-2 (gC2), since the amino terminus of gC1 blocks complement C5 from binding to C3b, while gC2 fails to interfere with this activity. We previously reported that neutralization of HSV-1 gC-null virus by HSV antibody-negative human serum requires activation of C5 but not of downstream components of the classical complement pathway. In this report, we evaluated whether activation of C5 is sufficient to neutralize HSV-2 gC-null virus, or whether formation of the membrane attack complex by C6 to C9 is required for neutralization. We found that activation of the classical complement pathway up to C5 was sufficient to neutralize HSV-2 gC-null virus by HSV antibody-negative human serum. We evaluated the mechanisms by which complement activation occurred in seronegative human serum. Interestingly, natural immunoglobulin M antibodies bound to virus, which triggered activation of C1q and the classical complement pathway. HSV antibody-negative sera obtained from four individuals differed over an approximately 10-fold range in their potency for complement-mediated virus neutralization. These findings indicate that humans differ in the ability of their innate immune systems to neutralize HSV-1 or HSV-2 gC-null virus and that a critical function of gC1 and gC2 is to prevent C5 activation.

I11 Pharmacologic inhibition of the classical complement pathway enhances neuronal function and HD R6/2 mouse survival

2021 ◽  
Author(s):  
Alessia Tassoni ◽  
Vidhu Mathur ◽  
Joseph Vereen ◽  
Ellen Cahir-McFarland ◽  
Sethu Sankaranarayanan ◽  
...  
Keyword(s):  
Complement Pathway ◽  
Neuronal Function ◽  
Classical Complement Pathway ◽  
Pharmacologic Inhibition ◽  
Classical Complement
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