Ontogeny of the androgen receptor expression in the fetal and postnatal testis: Its relevance on Sertoli cell maturation and the onset of adult spermatogenesis

2009 ◽  
Vol 72 (11) ◽  
pp. 787-795 ◽  
Author(s):  
Rodolfo A. Rey ◽  
Mariana Musse ◽  
Marcela Venara ◽  
Héctor E. Chemes
Keyword(s):  
Androgen Receptor ◽  
Sertoli Cell ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Cell Maturation

scholarly journals Sertoli Cell Androgen Receptor Expression Regulates Temporal Fetal and Adult Leydig Cell Differentiation, Function, and Population Size

Endocrinology ◽  
2013 ◽  
Vol 154 (9) ◽  
pp. 3410-3422 ◽  
Author(s):  
Rasmani Hazra ◽  
Mark Jimenez ◽  
Reena Desai ◽  
David J. Handelsman ◽  
Charles M. Allan
Keyword(s):  
Androgen Receptor ◽  
Population Size ◽  
Sertoli Cell ◽  
Serum Testosterone ◽  
Absolute Number ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Adult Type ◽  
Dependent Relationship ◽  
Regulated Expression

We recently created a mouse model displaying precocious Sertoli cell (SC) and spermatogenic development induced by SC-specific transgenic androgen receptor expression (TgSCAR). Here we reveal that TgSCAR regulates the development, function, and absolute number of Leydig cells (LCs). Total fetal and adult type LC numbers were reduced in postnatal and adult TgSCAR vs control testes, despite normal circulating LH levels. Normal LC to SC ratios found in TgSCAR testes indicate that SC androgen receptor (SCAR)-mediated activity confers a quorum-dependent relationship between total SC and LC numbers. TgSCAR enhanced LC differentiation, shown by elevated ratios of advanced to immature LC types, and reduced LC proliferation in postnatal TgSCAR vs control testes. Postnatal TgSCAR testes displayed up-regulated expression of coupled ligand-receptor transcripts (Amh-Amhr2, Dhh-Ptch1, Pdgfa-Pdgfra) for potential SCAR-stimulated paracrine pathways, which may coordinate LC differentiation. Neonatal TgSCAR testes displayed normal T and dihydrotestosterone levels despite differential changes to steroidogenic gene expression, with down-regulated Star, Cyp11a1, and Cyp17a1 expression contrasting with up-regulated Hsd3b1, Hsd17b3, and Srd5a1 expression. TgSCAR males also displayed elevated postnatal and normal adult serum testosterone levels, despite reduced LC numbers. Enhanced adult-type LC steroidogenic output was revealed by increased pubertal testicular T, dihydrotestosterone, 3α-diol and 3β-diol levels per LC and up-regulated steroidogenic gene (Nr5a1, Lhr, Cyp11a1, Cyp17a1, Hsd3b6, Srd5a1) expression in pubertal or adult TgSCAR vs control males, suggesting regulatory mechanisms maintain androgen levels independently of absolute LC numbers. Our unique gain-of-function TgSCAR model has revealed that SCAR activity controls temporal LC differentiation, steroidogenic function, and population size.

Effects of cypermethrin on cytokeratin 8/18 and androgen receptor expression in the adult mouse Sertoli cell

2017 ◽  
Vol 15 (2) ◽  
pp. 51-57 ◽  
Author(s):  
Hector Rodríguez ◽  
Hector Jara ◽  
Sergio Legua ◽  
Danitza Campos ◽  
Jorge Morales ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Sertoli Cell ◽  
Adult Mouse ◽  
Receptor Expression ◽  
Androgen Receptor Expression

Effect of Temporal Sertoli Cell Androgen Receptor Expression on Leydig Cell Development and Function in Mice.

2012 ◽  
Vol 87 (Suppl_1) ◽  
pp. 22-22
Author(s):  
Rasmani Hazra ◽  
Lisa Corcoran ◽  
Xin He ◽  
Reena Desai ◽  
David J. Handelsman ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Sertoli Cell ◽  
Leydig Cell ◽  
Cell Development ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
And Function

Androgen receptor expression in normal, hyperplastic and neoplastic hepatoid glands in the dog

2006 ◽  
Vol 81 (2) ◽  
pp. 231-236 ◽  
Author(s):  
G. Pisani ◽  
F. Millanta ◽  
D. Lorenzi ◽  
I. Vannozzi ◽  
A. Poli
Keyword(s):  
Androgen Receptor ◽  
Receptor Expression ◽  
Androgen Receptor Expression

scholarly journals Enhanced Sexual Behaviors and Androgen Receptor Immunoreactivity in the Male Progesterone Receptor Knockout Mouse

Endocrinology ◽  
2005 ◽  
Vol 146 (10) ◽  
pp. 4340-4348 ◽  
Author(s):  
Johanna S. Schneider ◽  
Carly Burgess ◽  
Nicole C. Sleiter ◽  
Lydia L. DonCarlos ◽  
John P. Lydon ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Androgen Receptor ◽  
Progesterone Receptor ◽  
Sexual Behaviors ◽  
Gene Deletion ◽  
Biological Significance ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Testicular Development ◽  
Testicular Weight

Reproductive and behavioral functions of progesterone receptors (PRs) in males were assessed by examining consequences of PR gene deletion. Basal hormone levels were measured in male progesterone receptor knockout (PRKO) mice and compared to wild-type (WT) counterparts. RIA of serum LH, testosterone, and progesterone levels revealed no significant differences. Levels of FSH were moderately but significantly lower and inhibin levels were higher in PRKOs; these differences were not accompanied by gross differences in testicular weight or morphology. PRKOs exhibited significant alterations in sexual behavior. In initial tests PRKOs exhibited reduced latency to mount, compared with WT. In second sessions, PRKOs again showed a significantly reduced latency to mount and increased likelihood of achieving ejaculation. RU486 treatment in WT produced increased mount and intromission frequency and decreased latency to intromission. In anxiety-related behavior tests, PRKO mice exhibited intermediate anxiety levels, compared with WT, suggesting that enhanced sexual behavior in PRKOs is not secondary to reduced anxiety. Immunohistochemical analysis revealed significantly enhanced androgen receptor expression in the medial preoptic nucleus and bed nucleus of the stria terminalis of PRKO. We conclude that testicular development and function and homeostatic regulation of the hypothalamic-pituitary testicular axis are altered to a lesser extent by PR gene deletion. In contrast, PR appears to play a substantial role in inhibiting the anticipatory/motivational components of male sexual behavior in the mouse. The biological significance of this inhibitory mechanism and the extent to which it is mediated by reduced androgen receptor expression remain to be clarified.

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