scholarly journals Pathological gallbladder wall thickening is associated with advanced chronic liver disease and independent of serum albumin

2021 ◽  
Author(s):  
Sebastian C. B. Bremer ◽  
Richard F. Knoop ◽  
Melissa Porsche ◽  
Ahmad Amanzada ◽  
Volker Ellenrieder ◽  
...  
Keyword(s):  
Liver Disease ◽  
Serum Albumin ◽  
Chronic Liver Disease ◽  
Gallbladder Wall ◽  
Chronic Liver ◽  
Wall Thickening ◽  
Gallbladder Wall Thickening

Gallbladder wall thickening (congestive cholecystopathy) in chronic liver disease: a sign of portal hypertension

1990 ◽  
Vol 63 (756) ◽  
pp. 922-925 ◽  
Author(s):  
S. H. Saverymuttu ◽  
A. Grammatopoulos ◽  
C. I. Meanock ◽  
J. D. Maxwell ◽  
A. E. A. Joseph
Keyword(s):  
Portal Hypertension ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Gallbladder Wall ◽  
Chronic Liver ◽  
Wall Thickening ◽  
Gallbladder Wall Thickening

scholarly journals Thickening of Gallbladder Wall in Chronic Liver Disease - A Marker for Esophageal Varices

2013 ◽  
Vol 6 (1) ◽  
pp. 18-20
Author(s):  
Shamsi Ara Begum ◽  
Arif Akbar Saibal ◽  
Kanta Das ◽  
Sharmistha Dey ◽  
Akhtar Uddin Ahmed ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Esophageal Varices ◽  
Gallbladder Wall ◽  
Chronic Liver ◽  
Wall Thickening ◽  
Oesophageal Varices ◽  
Group A ◽  
The Mean ◽  
Group B

This study was done to find out the relationship between gallbladder wall thickening and esophageal varices in chronic liver disease (CLD) patients. A total of 61 CLD patients were included and divided into two groups. Group A included 13 CLD patients with no oesophageal varices and Group B composed of 48 CLD patients with esophageal varices. Mean gallbladder wall thickness (GBWT) of Group B was 5.6±0.2mm compared to 2.7±0.1mm of Group A. The mean differences of GBWT were statistically significant between group A and group B (P<0.05). The mean GBWT was significantly (p<0.05) higher in CLD patients with grade III and IV varices (6.1±.8 mm) compared to grade I and II (3.9±0.7 mm). The result suggests that GBWT may be considered as an important marker for the presence of esophageal varices in CLD patients. DOI: http://dx.doi.org/10.3329/imcj.v6i1.14713 Ibrahim Med. Coll. J. 2012; 6(1): 18-20

Antibodies to polymerized human serum albumin in acute and chronic liver disease

Hepatology ◽  
1987 ◽  
Vol 7 (5) ◽  
pp. 906-912 ◽  
Author(s):  
William M. Lee ◽  
Lizabeth McLeod ◽  
Kylie Martin ◽  
David L. Emerson ◽  
Robert M. Galbraith
Keyword(s):  
Liver Disease ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Polymerized Human Serum Albumin

scholarly journals A Study of Hypoalbuminaemia in Chronic Liver Disease and its Correlation with Development of Esophageal Varices

2013 ◽  
Vol 22 (1) ◽  
pp. 17-20
Author(s):  
SF Hossain ◽  
QT Islam ◽  
MR Siddiqui ◽  
A Hossain ◽  
N Jahan ◽  
...  
Keyword(s):  
Liver Disease ◽  
Serum Albumin ◽  
Chronic Liver Disease ◽  
Esophageal Varices ◽  
Predictive Value ◽  
Chronic Liver ◽  
Full Blood Count ◽  
Group A ◽  
Pugh Class ◽  
Group B

Background: The aim and objective of this study was to evaluate relationship of serum albumin and esophageal varices in chronic liver disease (CLD) admitted in the medicine unit and gastroenterology department of Dhaka Medical College Hospital. Method: In this cross-sectional study, a total number of 100 randomly selected, clinically diagnosed patients of chronic liver disease were studied from June 2010 to November 2010 (6 months). All patients were assessed as per Child-Pugh class and had full blood count, HBsAg, Anti-HCV antibodies by ELISA, abdominal ultrasound and Endoscopy of upper gastrointestinal tract. Patients were divided into Group A (serum albumin <3.5 gm%) and Group B (3.55). Result: Seventy-three male (73%) and twenty seven female patients (27%)] with age range of 16 to 75 years were evaluated. Out of 100 patients 24% were in between 46-55 years age group. 63% patient fall in child Pugh class A group, 32% fall in child Pugh class B & 5% fall in child Pugh class C. Mean Serum albumin was 3.8 gm%, (range 2.4-4.9). Esophageal varices (EV) were present in 32 patients (32%) and absent in 68 patients (68%). Group A had 29 patients (29% of the total) with 18 patients (62.06%) having EV. Group B had 71 patients (71% of the total) with 14 patients (19.71%) having EV. Sensitivity of hypoalbuminaemia as a marker of EV was 56% and specificity 83.8%, positive predictive value 62.06% and negative predictive value 80.2% and Odds ratio was 6.6. P value is <0.001. Conclusion: In Group A that is hypoalbuminaemia (<3.5 gm%), the incidence of Esophageal varices was more than Group B that is albumin level (>3.5gm%). Hypoalbuminemia is a good surrogate marker for the presence of esophageal varices in CLD. DOI: http://dx.doi.org/10.3329/bjmed.v22i1.13595 Bangladesh J Medicine 2011; 22: 17-20

scholarly journals By-pass Marker for detecting Esophageal Varices in Patients with Chronic Liver Disease

2018 ◽  
Vol 28 (2) ◽  
pp. 15-21
Author(s):  
Sandipan Ghose ◽  
Md Azizul Hoque ◽  
MK Rahman ◽  
MMR Khan ◽  
Mohd Harun Or Rashid ◽  
...  
Keyword(s):  
Liver Disease ◽  
Gall Bladder ◽  
Chronic Liver Disease ◽  
Esophageal Varices ◽  
Gastrointestinal Endoscopy ◽  
Bladder Wall ◽  
Chronic Liver ◽  
Wall Thickening ◽  
Gall Bladder Wall ◽  
Grade 11

This study was designed to make a relation between gall bladder wall thickening (GBWT) measured by ultrasonography and esophageal varices (EV) measured byupper gastrointestinal endoscopy in chronic liver disease patients. Itwas cross- sectional descriptive study. 50 cases ofChronic Liver Disease were recruited. GBWT was measured by ultrasonography and upper gastrointestinal endoscopy was done for assessment of the presence and grade of EV in all cases. Among 50 cases, 34 (68%) were male and 16(32%) were female. Mean age (±SD) of the study population was 46.7 (±13.28) years of age. Esophageal varices were found in 42(84%) cases and 8(16%) cases had no varix. Among 42 cases of esophageal varices 9 cases had grade-I, 17 cases had grade-II and 16 cases had Grade-III esophageal varices. Gall bladder wall thickness up to 3mm was considered as normal. In this study GBWT value between (1-3) mm8 cases had no EV GBWT value between (3.1-5.9) mm ,10 cases had EV(9 cases had grade 1 and 1 case had grade 11 EV); GBWT value between (6-8.9) mm, 16 cases had grade 11 EV and GBWT value between (9-12) mm 16 cases had grade 111 EV. A significant statistical correlation was found between the level of GBWT and EV (P<0.001) and also between mean GBWT and EV (P<0.001). This study shows that the presence of EV is directly related to the level of GBWT and there is also association with the grade of EV and level of GBWT. This finding will permit the use of GBWT as a preliminary indirect parameter that will predict the presence EV. It can help clinicians in determining the urgency of care, especially where endoscopy facilities are not available.TAJ 2015; 28(2): 15-21

Impact of Intensive Dietary Counseling on Serum Albumin in Haemodialysis Patients with Chronic Liver Disease

2017 ◽  
Vol 68 (11) ◽  
pp. 2573-2577
Author(s):  
Luciana Carmen Nitoi ◽  
Laura Florea ◽  
Alina Aspazia Stefan ◽  
Cristian Ionita ◽  
Carina Andrei ◽  
...  
Keyword(s):  
Liver Disease ◽  
Nutritional Status ◽  
Serum Albumin ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Biochemical Tests ◽  
Anthropometric Measures ◽  
Dietary Counseling ◽  
Inflammatory Status ◽  
The Impact

People on maintenance haemodialysis (MHD) are at risk of developing malnutrition, which is defined as the consequence of insufficient food intake or a suboptimal quality diet. The kidney and the liver play a central role in protein metabolism. The major aim of the study was to evaluate, for the first time in Romania, the impact of intensive dietary counseling and personalised diets on serum albumin (SA) and others nutritional parameters, but also the relationship between albumin level, inflammation and nutritional status in a cohort of haemodialysis patients which associate or not chronic liver disease (CLD). We prospectively analysed the inflammatory status and malnutrition in 162 HD patients, mean age 56�13 years, from a single dialysis centre. At baseline we evaluated: a. calorie-protein intake using patient�s diet history with the help of 72 hrs recall method;b. nutritional status by anthropometric measures- post dialysis body weight (BW), body mass index (BMI), TSF (tricipital skinfold), MAC (mid-arm circumference), MAMC (mid-arm muscle circumference);c. modified subjective global assessment score (mSGA);d. biochemical tests: pre-dialysis serum albumin, serum creatinine, alkaline reserve, Kt/V and Protein C Reactive (CRP). The patients were followed-up for 6 months.

scholarly journals The association between serum albumin and depression in chronic liver disease may differ by liver histology

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Junyan Cao ◽  
Weihong Qiu ◽  
Yong Yu ◽  
Na Li ◽  
Huixiang Wu ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Liver Disease ◽  
Serum Albumin ◽  
Chronic Liver Disease ◽  
The United States ◽  
Chronic Liver ◽  
Liver Histology ◽  
Depression Symptoms ◽  
Inverse Association ◽  
The Impact

Abstract Background There are conflicting results regarding the association between chronic liver disease (CLD) and depression and the underlying biological mechanisms are lack of investigation. To address the impact of depression and its effects on the management of CLD, its biological marker is critical to be identified. The present study explored the association between serum albumin and depression in CLD patients and whether the association varied in different liver histological stages. Methods Based on the United States National Health and Nutrition Examination Survey 2017–2018, the data of serum albumin and depressive symptoms from 627 participants with CLD were used. Depression symptoms were assessed with the nine-item Patient Health Questionnaire (PHQ-9). We used multivariate linear regression to evaluate the association between serum albumin and PHQ-9 scores. Stratified analysis was performed according to the liver histology examined by vibration controlled transient elastography. Results Serum albumin level was inversely associated with PHQ-9 scores in the multivariate regression model after adjusting for mainly potential confounders (β = − 1.113, 95% CI: − 2.065 to − 0.162, P = 0.0221). In the subgroup analysis stratified by gender, controlled attenuation parameter (CAP) and liver stiffness measurement (LSM), the inverse association remained significant in female (β = − 2.002, 95% CI: − 3.515 to − 0.489, P = 0.0100), patients with CAP < 274 dB/m (β = − 2.215, 95% CI: − 3.621 to − 0.808, P = 0.0023) and patients with LSM ≥8.2 kPa (β = − 4.074, 95% CI: − 6.237 to − 1.911, P = 0.0003). Moreover, the association was much stronger when the serum albumin was higher than 3.4 g/dL among patients with LSM ≥8.2 kPa (β = − 4.835, 95% CI: − 7.137 to − 2.533, P < 0.0001). Conclusion Our study revealed an inverse association between serum albumin and depression in CLD patients and this association differed according to liver histological changes. Serum albumin could be a warning marker for depressive symptoms in CLD patients. It is essential for taking corresponding intervention strategies.

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