Orthostatic dizziness in Parkinson's disease is attributed to cerebral hypoperfusion: A transcranial doppler study

2017 ◽  
Vol 45 (6) ◽  
pp. 337-342 ◽  
Author(s):  
Jinse Park ◽  
Hee-Tae Kim ◽  
Kang Min Park ◽  
Sam Yeol Ha ◽  
Sung Eun Kim ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Transcranial Doppler ◽  
Cerebral Hypoperfusion ◽  
Doppler Study

Is cerebral autoregulation impaired in Parkinson's disease? A transcranial Doppler study

2007 ◽  
Vol 254 (1-2) ◽  
pp. 49-53 ◽  
Author(s):  
N. Vokatch ◽  
H. Grötzsch ◽  
B. Mermillod ◽  
P.R. Burkhard ◽  
R. Sztajzel
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Transcranial Doppler ◽  
Cerebral Autoregulation ◽  
Doppler Study

Potential Mechanism of Venous System for Leukoaraiosis: From post-mortem to in vivo Research

2019 ◽  
Vol 19 (3-4) ◽  
pp. 101-108
Author(s):  
Di Nan ◽  
Yingying Cheng ◽  
Liangshu Feng ◽  
Mingming Zhao ◽  
Di Ma ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Small Vessel Disease ◽  
Venous System ◽  
Cerebral Hypoperfusion ◽  
Periventricular White Matter ◽  
Post Mortem ◽  
In Vivo Evaluation ◽  
In Vivo Models

Background: Leukoaraiosis (LA), widely accepted as a feature of cerebral small vessel disease, significantly increases the incidence of stroke, dementia, and death. Cerebral small artery disease has been considered as one of the main causes of LA. However, since the term “venous collagenosis” (VC) was proposed in an atrophy research in 1995, there have been pathological and neuroimaging studies proving the association between the venous system and LA in aging, Alz­heimer’s disease (AD), and Parkinson’s disease. Summary: Autopsy studies confirmed that thickening of the lumen wall in venules, which results from the deposition of collagen I and III, leading to vessel stenosis or occlusion, is closely associated with LA. Susceptibility-weighted imaging research revealed a controversial association of deep medullary veins and LA in vivo, regarding which there are no standard criteria currently. Nevertheless, retinal venous changes had been reported to increase the risk of LA development, providing a novel way for in vivo evaluation. As for the internal jugular vein, jugular venous reflux could double the LA score in aging and modulate circulation of cerebral spinal fluids. Key Messages: Disruption of the venous system was notably associated with LA in aging, AD, and Parkinson’s disease post-mortem and in in vivo models. The venous pathological changes may induce cerebral hypoperfusion, drainage system disruption, and vasogenic oedema in the veins around the periventricular white matter. The clarification of VC in LA may provide an early prevention and early treatment strategy for LA patients.

Case 41: Atypical Parkinsonism

2019 ◽  
pp. 237-240
Author(s):  
Peter Novak
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Multiple System Atrophy ◽  
Small Fiber Neuropathy ◽  
Cerebral Hypoperfusion ◽  
Vitamin B ◽  
Atypical Parkinsonism ◽  
Small Fiber

The testing for this patient showed minimal dysautonomia, small fiber neuropathy, and orthostatic cerebral hypoperfusion syndrome (OCHOS). Small fiber neuropathy can be due to vitamin B12 deficiency. Mild dysautonomia is not suggestive of Parkinson’s disease or multiple system atrophy.

scholarly journals Comparing Cerebral Perfusion in Alzheimer's Disease and Parkinson's Disease Dementia: An ASL-MRI Study

2014 ◽  
Vol 34 (6) ◽  
pp. 964-970 ◽  
Author(s):  
Campbell J Le Heron ◽  
Sarah L Wright ◽  
Tracy R Melzer ◽  
Daniel J Myall ◽  
Michael R MacAskill ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Parkinson's Disease ◽  
Blood Flow ◽  
Sex Education ◽  
Cerebral Perfusion ◽  
Principal Component ◽  
Cerebral Hypoperfusion ◽  
Parkinson’S Disease Dementia

Emerging evidence suggests that Alzheimer's disease (AD) and Parkinson's disease dementia (PDD) share neurodegenerative mechanisms. We sought to directly compare cerebral perfusion in these two conditions using arterial spin labeling magnetic resonance imaging (ASL-MRI). In total, 17 AD, 20 PDD, and 37 matched healthy controls completed ASL and structural MRI, and comprehensive neuropsychological testing. Alzheimer's disease and PDD perfusion was analyzed by whole-brain voxel-based analysis (to assess absolute blood flow), a priori specified region of interest analysis, and principal component analysis (to generate a network differentiating the two groups). Corrections were made for cerebral atrophy, age, sex, education, and MRI scanner software version. Analysis of absolute blood flow showed no significant differences between AD and PDD. Comparing each group with controls revealed an overlapping, posterior pattern of hypoperfusion, including posterior cingulate gyrus, precuneus, and occipital regions. The perfusion network that differentiated AD and PDD groups identified relative differences in medial temporal lobes (AD < PDD) and right frontal cortex (PDD < AD). In conclusion, the pattern of cerebral hypoperfusion is very similar in AD and PDD. This suggests closely linked mechanisms of neurodegeneration mediating the evolution of dementia in both conditions.

Tilt-table test during transcranial Doppler monitoring in Parkinson's disease

2003 ◽  
Vol 10 (1) ◽  
pp. 41-46 ◽  
Author(s):  
Silvia Angeli ◽  
Roberta Marchese ◽  
Giovanni Abbruzzese ◽  
Carlo Gandolfo ◽  
Massimo Conti ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Transcranial Doppler ◽  
Tilt Table Test ◽  
Tilt Table
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