scholarly journals Varying patterns of brachial artery flow-mediated dilatation in women with polycystic ovary syndrome and controls: An application of the group-based trajectory modeling

2015 ◽  
Vol 44 (1) ◽  
pp. 46-54 ◽  
Author(s):  
Michelle L. Meyer ◽  
Ping G. Tepper ◽  
Emma Barinas-Mitchell ◽  
Mary T. Korytkowski ◽  
Evelyn O. Talbott
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Brachial Artery ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Trajectory Modeling ◽  
Flow Mediated Dilatation ◽  
Artery Flow

scholarly journals Brachial artery conductance during reactive hyperemia is increased in women with polycystic ovary syndrome

2011 ◽  
Vol 155 (1) ◽  
pp. 49-53 ◽  
Author(s):  
Nazia Raja-Khan ◽  
Showieb A. Shuja ◽  
Allen R. Kunselman ◽  
Cynthia S. Hogeman ◽  
Laurence M. Demers ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Brachial Artery ◽  
Polycystic Ovary ◽  
Reactive Hyperemia ◽  
Ovary Syndrome

scholarly journals Improvement of endothelial function with metformin and rosiglitazone treatment in women with polycystic ovary syndrome

2008 ◽  
Vol 159 (4) ◽  
pp. 399-406 ◽  
Author(s):  
Mojca Jensterle ◽  
Miran Sebestjen ◽  
Andrej Janez ◽  
Janez Prezelj ◽  
Tomaz Kocjan ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Endothelial Function ◽  
Brachial Artery ◽  
Polycystic Ovary ◽  
Early Stage ◽  
Free Testosterone ◽  
Model Assessment ◽  
Ovary Syndrome ◽  
Insulin Sensitizer ◽  
Insulin Resistant

ObjectiveThere is evidence of preclinical cardiovascular disease even in young women with polycystic ovary syndrome (PCOS). The aim of our study was to assess and compare the effects of metformin (MET) and rosiglitazone (ROSI) on endothelial function in PCOS patients.MethodsFor 6 months, 26 women with PCOS received either MET or ROSI. Blood samples for assessment of androgens, lipids, and high-sensitive C-reactive protein were taken at baseline and at endpoint. Endothelium-dependent flow-mediated dilation (FMD) and glyceryl trinitrate-induced endothelium-independent dilation of brachial artery were studied before and after treatment. Homeostasis model assessment (HOMAIR) calculation was applied as a measure of insulin resistance (IR).ResultsWith treatment, FMD of brachial artery improved significantly from 4.2±6.6 to 10.2±5.9% in MET group (P=0.036) and from 2.9±3.2 to 7.6±4.9% in ROSI group (P=0.026), MET being as effective as ROSI (P=0.70). The endothelium-independent dilation did not change. Additionally, administration of MET was associated with a significant decrease in HOMAIR (P=0.003), serum total and serum-free testosterone (P=0.045 and P=0.008 respectively) and significantly higher frequencies of menstrual bleeding (P=0.006).ConclusionsA 6-month therapy with insulin sensitizers, MET and ROSI, resulted in marked improvement of endothelial function in young PCOS patients without clinically evident atherosclerosis who were not severely insulin resistant. Neither drug was superior to the other. We conclude that therapeutic intervention with either insulin sensitizer may reverse the atherosclerotic process in PCOS patients at its early stage.

Reply of the Authors: Flow-mediated dilatation in polycystic ovary syndrome women

2009 ◽  
Vol 91 (5) ◽  
pp. e24-e24
Author(s):  
Senay Arikan ◽  
Hatice Akay ◽  
Mithat Bahceci ◽  
Alpaslan Tuzcu ◽  
Deniz Gokalp
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Flow Mediated Dilatation

Flow-mediated dilatation in polycystic ovary syndrome women

2009 ◽  
Vol 91 (5) ◽  
pp. e23-e23 ◽  
Author(s):  
Wellington P. Martins ◽  
Carolina O. Nastri ◽  
Carolina S. Vieira ◽  
Rui A. Ferriani
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Flow Mediated Dilatation
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