Contrast-enhanced endoscopic ultrasonography can predict a higher malignant potential of gastrointestinal stromal tumors by visualizing large newly formed vessels

2014 ◽  
Vol 43 (2) ◽  
pp. 89-97 ◽  
Author(s):  
Yasunobu Yamashita ◽  
Jun Kato ◽  
Kazuki Ueda ◽  
Yasushi Nakamura ◽  
Hiroko Abe ◽  
...  
Keyword(s):  
Endoscopic Ultrasonography ◽  
Gastrointestinal Stromal Tumors ◽  
Malignant Potential ◽  
Stromal Tumors ◽  
Contrast Enhanced

The efficacy of PET-CT for predicting the malignant potential of gastrointestinal stromal tumors

Surgery Today ◽  
2012 ◽  
Vol 43 (10) ◽  
pp. 1162-1167 ◽  
Author(s):  
Kozo Yoshikawa ◽  
Mitsuo Shimada ◽  
Nobuhiro Kurita ◽  
Hirohiko Sato ◽  
Takashi Iwata ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Malignant Potential ◽  
Stromal Tumors ◽  
Pet Ct

Gastrointestinal Stromal Tumors: A “Benign” Tumor with Hepatic Metastasis after 11 Years

1998 ◽  
Vol 84 (1) ◽  
pp. 78-81 ◽  
Author(s):  
Carlo Ballarini ◽  
Mattia Intra ◽  
Andrea Pisani Ceretti ◽  
Francesco Prestipino ◽  
Filippo Maria Bianchi ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Hepatic Metastasis ◽  
Tumor Size ◽  
Gastrointestinal Stromal Tumors ◽  
Cellular Proliferation ◽  
Malignant Potential ◽  
Mitotic Count ◽  
Proliferation Index ◽  
Ki 67 ◽  
Stromal Tumors

Gastrointestinal stromal tumors (GIST) constitue the largest category of primary non-epithelial neoplasms of the stomach and small bowel. They are characterized by a remarkable cellular variability and their malignant potential is sometimes difficult to predict. Very recent studies, using mitotic count and tumor size as the best determinants of biological behavior, divide GISTs into three groups: benign, borderline and malignant tumors. We report on a male patient who underwent a right hepatectomy for a large metastasis 11 years after the surgical treatment of an antral-pyloric gastric neoplasm, histologically defined as leiomyoblastoma and with clinical, morphological and immunohistochemical features of benignity (low mitotic count, tumor size < 5 cm, low cellular proliferation index). Histological and immunohistochemical analysis of the hepatic metastasis showed the cellular proliferation index (Ki-67) to be positive in 25% of neoplastic cells, as opposed to the primary gastric tumor in which Ki-67 was positive in only 5% of neoplastic cells. In conclusion, although modern immunohistochemical techniques are now available to obtain useful prognostic information, the malignant potential of GISTs is sometimes difficult to predict: neoplasms clinically and histologically defined as benign could metastasize a long time after oncologically correct surgical treatment. Therefore, benign GISTs also require consistent, long-term follow-up.

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