scholarly journals The influence of gender on carotid artery compliance and distensibility in children and adults

2012 ◽  
Vol 41 (6) ◽  
pp. 340-346 ◽  
Author(s):  
Kara L. Marlatt ◽  
Aaron S. Kelly ◽  
Julia Steinberger ◽  
Donald R. Dengel
Keyword(s):  
Carotid Artery ◽  
Carotid Artery Compliance

C-reactive protein genetics is associated with carotid artery compliance in men in The Cardiovascular Risk in Young Finns Study

2008 ◽  
Vol 196 (2) ◽  
pp. 841-848 ◽  
Author(s):  
C. Eklund ◽  
M. Kivimäki ◽  
Md. Shaheenul Islam ◽  
M. Juonala ◽  
M. Kähönen ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Carotid Artery ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Carotid Artery Compliance ◽  
Young Finns Study

scholarly journals Lack of changes in carotid artery compliance with systemic nitric oxide synthase inhibition

2014 ◽  
Vol 28 (8) ◽  
pp. 494-499 ◽  
Author(s):  
J Sugawara ◽  
Y Saito ◽  
S Maeda ◽  
M Yoshizawa ◽  
H Komine ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Carotid Artery ◽  
Oxide Synthase ◽  
Carotid Artery Compliance

Abstract 13: Mineralocorticoid Receptor Blockade does not Result in Arterial Destiffening in Healthy Older Adults

Hypertension ◽  
2012 ◽  
Vol 60 (suppl_1) ◽  
Author(s):  
Demetra D Christou ◽  
Jeung-Ki Yoo ◽  
Moon-Hyon Hwang ◽  
Meredith Luttrell ◽  
Han-Kyul Kim ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
Carotid Artery ◽  
Arterial Stiffness ◽  
Mineralocorticoid Receptor ◽  
Augmentation Index ◽  
Stiffness Index ◽  
Double Blind ◽  
Healthy Older Adults ◽  
Carotid Artery Compliance

Arterial stiffness, an independent predictor of cardiovascular disease, is increased in aging, but the underlying mechanisms are not completely understood. We hypothesized that mineralocorticoid receptor (MR) activation is partly responsible for increased arterial stiffness and that MR blockade would lead to arterial destiffening in healthy older adults. To test this hypothesis, we administered in a randomized, double blind, crossover study, 100 mg of Eplerenone (MR blocker) or placebo once per day for one month with one month washout, in 23 healthy older adults (age, 64±1 years; mean±SE) and assessed arterial stiffness (aortic, arm and leg pulse wave velocity (PWV; doppler flowmeter) and carotid artery compliance, distensibility, beta-stiffness index, augmentation index (high resolution ultrasonography and applanation tonometry). Despite reductions in blood pressure in response to Eplerenone (systolic blood pressure: 127±3 vs. 120±2 mmHg, P=0.01; diastolic blood pressure: 74±1 vs.72±1 mmHg, P=0.02; placebo vs. Eplerenone), arterial stiffness did not change (aortic PWV, 9.2±1.2 vs. 8.9±1.2m/sec, P=0.5; arm PWV, 11.4±0.6 vs. 11.7±0.7 m/sec, P=0.7; leg PWV, 13.4±0.4 vs.12.8±0.5 m/sec, P=0.3; carotid artery compliance, 0.17±0.02 vs. 0.16±0.02 mm 2 /mmHg, P=0.6; distensibility, 12.7±1.6 vs.13.6±1.5 10 -3 kPa -1 , P=0.6; beta stiffness index, 3.2±0.3 vs. 3.4±0.3, P=0.5; augmentation index, 24.3±2.9 vs. 22.0±2.9 %, P=0.3, placebo vs. Eplerenone). In conclusion, MR blockade does not result in arterial destiffening in healthy older adults despite reductions in blood pressure.

Acute effects of supramaximal exercise on carotid artery compliance and pulse pressure in young men and women

2010 ◽  
Vol 110 (4) ◽  
pp. 729-737 ◽  
Author(s):  
Lindy Rossow ◽  
Christopher A. Fahs ◽  
Myriam Guerra ◽  
Sae Young Jae ◽  
Kevin S. Heffernan ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Pulse Pressure ◽  
Young Men ◽  
Supramaximal Exercise ◽  
Acute Effects ◽  
Men And Women ◽  
Carotid Artery Compliance

Deletion polymorphism in the α2B-adrenergic receptor gene is associated with flow-mediated dilatation of the brachial artery

2002 ◽  
Vol 103 (5) ◽  
pp. 517-524 ◽  
Author(s):  
Paula HEINONEN ◽  
Laura JARTTI ◽  
Mikko J. JÄRVISALO ◽  
Ullamari PESONEN ◽  
Jaakko A. KAPRIO ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Endothelial Function ◽  
Brachial Artery ◽  
Adrenergic Receptor ◽  
Intima Media Thickness ◽  
Deletion Variant ◽  
Media Thickness ◽  
Increased Risk ◽  
Flow Mediated Dilatation ◽  
Carotid Artery Compliance

A deletion variant of the α2B-adrenergic receptor (α2B-AR) has been associated with an increased risk of acute cardiac events in middle-aged men. Our aim was to determine the possible associations between the α2B-AR gene deletion variant and indicators of subclinical atherosclerosis in the brachial and carotid arteries. A total of 148 middle-aged men participating in an epidemiological twin study on risk factors for subclinical coronary heart disease were genotyped using PCR. Flow-mediated dilatation (FMD) of the brachial artery, carotid artery compliance and carotid intima-media thickness were measured using high-resolution ultrasound. FMD was 6.2±5.0% in subjects with the I/I (insertion/insertion) genotype, 5.5±4.1% in the I/D (insertion/deletion) group and 4.1±3.8% in the D/D (deletion/deletion) group (P = 0.03 for trend). In multivariate regression analysis controlling for age, presence of hypertension, smoking, use of angiotensin-converting enzyme inhibitors and plasma levels of low-density lipoprotein cholesterol and lipoprotein (a), the association between the α2B-AR genotype and FMD remained significant (P = 0.04 for trend). The α2B-AR genotype was not associated with intima-media thickness or carotid artery compliance. These findings indicate that subjects homozygous for the deletion allele of α2B-AR appear to have an increased risk of impaired endothelial function, which may provide an explanation for the previously observed increased risk of myocardial infarction in male subjects with this genotype. It is not known whether the association of the α2B-AR polymorphism with endothelial function is direct, or is mediated via altered sympathetic activation.

Ascorbic acid does not affect large elastic artery compliance or central blood pressure in young and older men

2004 ◽  
Vol 286 (4) ◽  
pp. H1528-H1534 ◽  
Author(s):  
Iratxe Eskurza ◽  
Kevin D. Monahan ◽  
Jed A. Robinson ◽  
Douglas R. Seals
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Ascorbic Acid ◽  
Carotid Artery ◽  
Vitamin C ◽  
Older Men ◽  
Healthy Men ◽  
Arterial Blood ◽  
Elastic Artery ◽  
Carotid Artery Compliance

Large elastic artery compliance is reduced and arterial blood pressure (BP) is increased in the central (cardiothoracic) circulation with aging. Reactive oxygen species may tonically modulate central arterial compliance and BP in humans, and oxidative stress may contribute to adverse changes with aging. If so, antioxidant administration may have beneficial effects. Young (Y; 26 ± 1 yr, mean ± SE) and older (O; 63 ± 2 yr, mean ± SE) healthy men were studied at baseline and during acute (intravenous infusion; Y: n = 13, O: n = 12) and chronic (500 mg/day for 30 days; Y: n = 10, O: n = 10) administration of ascorbic acid (vitamin C). At baseline, peripheral (brachial artery) BP did not differ in the two groups, but carotid artery compliance was 43% lower (1.2 ± 0.1 vs. 2.1 ± 0.1 mm2/mmHg × 10–1, P < 0.01) and central (carotid) BP (systolic: 116 ± 5 vs. 101 ± 3 mmHg, P < 0.05, and pulse pressure: 43 ± 4 vs. 36 ± 3 mmHg, P = 0.16), carotid augmentation index (AIx; 27.8 ± 7.8 vs. –20.0 ± 6.6%, P < 0.001), and aortic pulse wave velocity (PWV; 950 ± 88 vs. 640 ± 38 cm/s, P < 0.01) were higher in the older men. Plasma ascorbic acid concentrations did not differ at baseline (Y: 71 ± 5 vs. O: 61 ± 7 μmol/l, P = 0.23), increased ( P < 0.001) to supraphysiological levels during infusion (Y: 1,240 ± 57 and O: 1,056 ± 83 μmol/l), and were slightly elevated ( P < 0.001 vs. baseline) with supplementation (Y: 96 ± 5 μmol/l vs. O: 85 ± 6). Neither ascorbic acid infusion nor supplementation affected peripheral BP, heart rate, carotid artery compliance, central BP, carotid AIx, or aortic PWV (all P > 0.26). These results indicate that the adverse changes in large elastic artery compliance and central BP with aging in healthy men are not 1) mediated by ascorbic acid-sensitive oxidative stress (infusion experiments) and 2) affected by short-term, moderate daily ascorbic acid (vitamin C) supplementation.

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