scholarly journals Endothelial function in patients with and without diabetes mellitus with different degrees of coronary artery stenosis

2009 ◽  
Vol 37 (1) ◽  
pp. 35-39 ◽  
Author(s):  
Iana I. Simova ◽  
Stefan V. Denchev ◽  
Simeon I. Dimitrov ◽  
Raia Ivanova
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery ◽  
Endothelial Function ◽  
Coronary Artery Stenosis ◽  
Artery Stenosis

Evaluation of the Associations between Vascular Endothelial Function and Coronary Artery Stenosis in Patients with Elevated Blood Pressure during Coronary Angiography

2014 ◽  
Vol 17 (3) ◽  
pp. 150 ◽  
Author(s):  
Ruijin Yang ◽  
Jun Yu
Keyword(s):  
Blood Pressure ◽  
Coronary Artery ◽  
Endothelial Function ◽  
Coronary Artery Stenosis ◽  
Artery Stenosis ◽  
Elevated Blood Pressure ◽  
Control Group ◽  
Vascular Endothelial ◽  
Elevated Blood ◽  
Vascular Endothelial Function

<p><b>Objectives:</b> The aim of the present study is to explore the correlation between vascular endothelial function and coronary artery stenosis in non-hypertensive patients with elevated blood pressure under stress.</p><p><b>Methods:</b> This study included 1141 patients suspected of having coronary artery disease (CAD) without hypertension. Coronary arteriography and ultrasonic detection were used to measure the flow-mediated dilatation (FMD) function in the brachial artery. Patients were divided into 2 groups according to coronary angiography: experiment group, patients with blood pressure ? 140/90 mm Hg; control group, patients with blood pressure <140/90 mm Hg. The correlation between vascular endothelial function and coronary artery stenosis was observed.</p><p><b>Results:</b> The majority of the patients in the control group were found to have either normal coronary arteries or stenosis <50%. Patients in the experiment group (those with invasive blood pressure [IBP] >140/90) were more likely to have some degree of coronary artery stenosis. Specifically, there were significantly more patients with >50% stenosis in the experiment when compared with the control group (<i>P</i> < .05). The FMD in the experiment group was significantly lower than that in the control group (<i>P</i> < .05).</p><p><b>Conclusion:</b> The non-hypertensive patients with elevated blood pressure under stress had coronary artery stenosis, which was associated with vascular endothelial dysfunction.</p>

scholarly journals Association of Cardiovascular Risk Factors and Coronary Artery Lesion Among Coronary Artery Disease Patients

2015 ◽  
Vol 12 (2) ◽  
pp. 137-140 ◽  
Author(s):  
R Koju ◽  
S Humagain ◽  
K Khanal
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Coronary Artery Disease ◽  
Cardiovascular Risk ◽  
Coronary Artery ◽  
Cardiovascular Risk Factors ◽  
Coronary Stenosis ◽  
Coronary Artery Stenosis ◽  
Artery Stenosis ◽  
Artery Disease

Background Coronary artery disease (CAD) is associated with the numbers of risk factors causing coronary atherosclerosis. Coronary artery stenosis is mostly caused by coronary atherosclerosis.Objective This study aims to analyze the association between coronary artery stenosis and cardiovascular risk factors.Methods An observational study was conducted among CAD patients. The diagnostic coronary angiogram was performed from femoral approach using standard catheters and techniques to find out any abnormalities.Result A total 73 patients (44 male and 29 female) with coronary artery disease undergoing diagnostic coronary angiography was included with the documented cardiovascular risk factors. The coronary stenosis was found in 40 patients on the basis of stenosis grading. Among the established cardiovascular risk factors, sex, diabetes mellitus and smokers show are significantly associated with coronary stenosis among CAD patients. The present study shows the significant association of coronary stenosis among male CAD patients (OR 2.47; CI 0.94 – 6.48, p <0.05) and similar association has been observed in diabetes mellitus (OR 3.32; CI 1.12 – 9.84, p <0.05) and smoking (OR 4.10; CI 1.45 – 11.61, p <0.01).Conclusion The prevalence of CAD is increased with numbers of presence of cardiovascular risk factors. Male gender, diabetes mellitus and smoking are significantly associated with coronary stenosis among CAD patients. However, hypertension and dyslipidemia are comparable between coronary stenosis and no significant stenosis group.Kathmandu University Medical Journal Vol.12(2) 2014: 137-140

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