Interstitial pregnancy undetected during earlier first-trimester screening for fetal aneuploidy at 13 weeks' gestation

2009 ◽  
Vol 37 (3) ◽  
pp. 168-170 ◽  
Author(s):  
David M. Sherer ◽  
Mudar Dalloul ◽  
Margarita Sokolovski ◽  
Dorota Borawski ◽  
Freda Granderson ◽  
...  
Keyword(s):  
First Trimester ◽  
First Trimester Screening ◽  
Interstitial Pregnancy ◽  
Fetal Aneuploidy ◽  
Trimester Screening

Ten Years of Experience with First-Trimester Screening for Fetal Aneuploidy Employing Biochemistry from Gestational Weeks 6+0 to 13+6

2014 ◽  
Vol 37 (1) ◽  
pp. 51-57 ◽  
Author(s):  
Niels Tørring ◽  
Olav Bjørn Petersen ◽  
Niels Uldbjerg
Keyword(s):  
Trisomy 21 ◽  
High Performance ◽  
Protein A ◽  
First Trimester ◽  
Trisomy 13 ◽  
First Trimester Screening ◽  
Blood Samples ◽  
Fetal Aneuploidy ◽  
Trimester Screening ◽  
Gestational Week

Objectives: To validate the performance of first-trimester screening for fetal aneuploidy employing blood samples drawn in gestational weeks 6-13. Methods: Prospective combined first-trimester screening for fetal aneuploidy in Denmark was validated in two large datasets: (1) a dataset from the Central Denmark Region including 147,768 pregnancies from October 2003 to October 2013, and (2) a national dataset including 220,739 pregnancies from January 2008 to August 2011. Results: For trisomy 21, the weekly median multiple of the median (MoM) increased from 0.37 in week 6 to 0.70 in week 13 (pregnancy-associated plasma protein-A), and from 0.99 in week 6 to 2.68 in week 13 (free βhCG). The overall detection rate (DR) for fetal trisomy 21 was 91.2%. Employing blood samples from gestational week 9, the DR was 97% (p = 0.05). For fetal trisomy 18, trisomy 13 and triploidy, the overall DRs after first-trimester screening were 79.5, 86 and 85%. In the national dataset, the overall DR for trisomy 21 was 86.3% ranging from 89 (weeks 9 and 10) to 80% (weeks 12 and 13). Conclusion: The results from both datasets show that blood sampling in gestational weeks 9-10 is a robust and high-performance strategy, which can be applied for routine first-trimester screening in clinical practice.

scholarly journals First-trimester screening for fetal aneuploidy: biochemistry and nuchal translucency

1997 ◽  
Vol 10 (6) ◽  
pp. 381-386 ◽  
Author(s):  
F. Orlandi ◽  
G. Damiani ◽  
T. W. Hallaban ◽  
D. A. Krantz ◽  
J. N. Macri
Keyword(s):  
First Trimester ◽  
Nuchal Translucency ◽  
First Trimester Screening ◽  
Fetal Aneuploidy ◽  
Trimester Screening

Sensitivity of multiple first trimester sonomarkers in fetal aneuploidy detection

2015 ◽  
Vol 43 (3) ◽  
Author(s):  
Pharuhas Chanprapaph ◽  
Chitnapin Dulyakasem ◽  
Buraya Phattanchindakun
Keyword(s):  
Prenatal Diagnosis ◽  
First Trimester ◽  
Trisomy 13 ◽  
Ductus Venosus ◽  
Specific Marker ◽  
First Trimester Screening ◽  
Crown Rump Length ◽  
Fetal Aneuploidy ◽  
Single Marker ◽  
Trimester Screening

AbstractMultiple first trimester aneuploidy sonomarkers have been introduced recently.To evaluate the efficacy of first trimester sonomarkers in fetal aneuploidy detection without serum markers.There were entirely 280 fetuses with 11–13+6 weeks’ gestation (crown-rump -length between 45–84 mm) enrolled to assess nuchal translucency thickness (NT), nasal bone (NB), tricuspid regurgitation (TR) and ductus venosus (DV) flow. The performance of each single marker and multiple markers for major fetal aneuploidy screening were determined.Totally, 190 fetuses (67.85%) underwent invasive prenatal diagnosis with 14 major chromosome abnormalities identified including 4 cases of trisomy 21, 4 cases of trisomy 18, 3 cases of trisomy 13 and 3 cases of 45, XO. NT was the most accurate single marker with sensitivity of 71.43% and false-positive rate (FPR) of 4.14% while NB or TR was the most specific marker (99.6%) but lacked sensitivity. Among multiple first trimester-screening sonomarkers, NT plus TR evaluation were the most sensitive test (78.57%) with FPR of 4.76%.NT was the most accurate first trimester-screening marker for fetal aneuploidy. NT plus TR assessment as double-screening markers could improve the sensitivity by 7% leading to the lower number of unnecessary invasive prenatal diagnosis.

Noninvasive First-Trimester Screening for Fetal Aneuploidy

1997 ◽  
Vol 52 (2) ◽  
pp. 123-129 ◽  
Author(s):  
David M. Sherer ◽  
Allan T. Bombard ◽  
Leonard H. Kellner ◽  
Michael Y. Divon
Keyword(s):  
First Trimester ◽  
First Trimester Screening ◽  
Fetal Aneuploidy ◽  
Trimester Screening

Noninvasive First-Trimester Screening for Fetal Aneuploidy

1999 ◽  
Vol 54 (Supplement) ◽  
pp. 42-48
Author(s):  
David M. Sherer ◽  
Allan T. Bombard ◽  
Leonard H. Kellner ◽  
Michael Y. Divon
Keyword(s):  
First Trimester ◽  
First Trimester Screening ◽  
Fetal Aneuploidy ◽  
Trimester Screening
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