Enhanced trans -2,3-dihydro-3-hydroxyanthranilic acid production by pH control and glycerol feeding strategies in engineered Pseudomonas chlororaphis GP72

2018 ◽  
Vol 93 (6) ◽  
pp. 1618-1626 ◽  
Author(s):  
Sheng-Jie Yue ◽  
Muhammad Bilal ◽  
Shu-Qi Guo ◽  
Hong-Bo Hu ◽  
Wei Wang ◽  
...  
Keyword(s):  
Acid Production ◽  
Ph Control ◽  
Feeding Strategies ◽  
Pseudomonas Chlororaphis ◽  
Hydroxyanthranilic Acid ◽  
Pseudomonas Chlororaphis Gp72 ◽  
Glycerol Feeding

Production of trans-2,3-dihydro-3-hydroxyanthranilic acid by engineered Pseudomonas chlororaphis GP72

2017 ◽  
Vol 101 (17) ◽  
pp. 6607-6613 ◽  
Author(s):  
Hongbo Hu ◽  
Yifan Li ◽  
Kaiquan Liu ◽  
Jia Zhao ◽  
Wei Wang ◽  
...  
Keyword(s):  
Pseudomonas Chlororaphis ◽  
Hydroxyanthranilic Acid ◽  
Pseudomonas Chlororaphis Gp72

Development of a Plasmid-Free Biosynthetic Pathway for Enhanced Muconic Acid Production in Pseudomonas chlororaphis HT66

2018 ◽  
Vol 7 (4) ◽  
pp. 1131-1142 ◽  
Author(s):  
Songwei Wang ◽  
Muhammad Bilal ◽  
Yuanna Zong ◽  
Hongbo Hu ◽  
Wei Wang ◽  
...  
Keyword(s):  
Acid Production ◽  
Biosynthetic Pathway ◽  
Pseudomonas Chlororaphis ◽  
Muconic Acid

Development of a highly specific and productive process for n-caproic acid production: applying lessons from methanogenic microbiomes

2013 ◽  
Vol 69 (1) ◽  
pp. 62-68 ◽  
Author(s):  
M. T. Agler ◽  
C. M. Spirito ◽  
J. G. Usack ◽  
J. J. Werner ◽  
L. T. Angenent
Keyword(s):  
Carboxylic Acids ◽  
Acid Production ◽  
Waste Treatment ◽  
Liquid Product ◽  
Ph Control ◽  
Caproic Acid ◽  
Carbon Chain ◽  
Chain Elongation ◽  
Acid Extraction ◽  
High Productivity

High productivity and specificity in anaerobic digesters arise because complex microbiomes organize into a metabolic cascade to maximize energy recovery and to utilize the advantage that the gaseous end product methane freely bubbles out of the system. These lessons were applied to ascertain whether a reactor microbiome could be shaped to produce a different end product. The liquid product n-caproic acid was chosen, which is a 6-carbon-chain carboxylic acid that is valuable and that has a relatively low maximum solubility concentration for product recovery. Acetoclastic methanogenesis was inhibited by pH control and a route was provided for n-caproic acid extraction by implementing selective, in-line recovery. Next, ethanol was supplemented to promote chain elongation, which is a pathway in which short-chain carboxylic acids are elongated sequentially into medium-chain carboxylic acids with two-carbon units derived from ethanol. The reactor microbiome developed accordingly with the terminal process catalyzed by chain-elongating bacteria. As a result, n-caproic acid production rates increased to levels comparable to anaerobic digestion systems for solid waste treatment.

Efficient docosahexaenoic acid production by Schizochytrium sp. via a two-phase pH control strategy using ammonia and citric acid as pH regulators

2019 ◽  
Vol 77 ◽  
pp. 1-7 ◽  
Author(s):  
Feng-Wei Yin ◽  
Yu-Ting Zhang ◽  
Jia-Yi Jiang ◽  
Dong-Sheng Guo ◽  
Song Gao ◽  
...  
Keyword(s):  
Citric Acid ◽  
Docosahexaenoic Acid ◽  
Control Strategy ◽  
Acid Production ◽  
Ph Control ◽  
Two Phase
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