An extended bottleneck model: Accounting for the metabolic turnover effect in microorganisms

2008 ◽  
Vol 33 (3) ◽  
pp. 155-163 ◽  
Author(s):  
Pramod Agrawal ◽  
H. C. Lim ◽  
D. Ramkrishna
Keyword(s):  
Metabolic Turnover ◽  
Bottleneck Model

scholarly journals Metabolic Turnover Studies on the Two Major Forms of Rat and Rabbit Plasminogen

1974 ◽  
Vol 249 (5) ◽  
pp. 1434-1438
Author(s):  
Gerald E. Siefring ◽  
Francis J. Castellino
Keyword(s):  
Metabolic Turnover

scholarly journals Studies on the Metabolic Turnover of Muscle Proteins. Part I

1965 ◽  
Vol 39 (3) ◽  
pp. 109-113
Author(s):  
Ryuhei FUNABIKI ◽  
Makoto KANDATSU
Keyword(s):  
Muscle Proteins ◽  
Metabolic Turnover

scholarly journals Metabolic turnover of human c-rasH p21 protein of EJ bladder carcinoma and its normal cellular and viral homologs.

1984 ◽  
Vol 4 (8) ◽  
pp. 1647-1652 ◽  
Author(s):  
L S Ulsh ◽  
T Y Shih
Keyword(s):  
Bladder Carcinoma ◽  
Half Life ◽  
P21 Protein ◽  
Metabolic Turnover ◽  
Ras Genes ◽  
Murine Sarcoma Virus ◽  
Sarcoma Virus ◽  
Processed Products ◽  
Murine Sarcoma ◽  
P21 Proteins

The EJ bladder carcinoma oncogene is activated by a point mutation in the c-rasH proto-oncogene at the 12th amino acid codon. In an attempt to understand the mechanism of oncogenic activation, a comparative study was undertaken to examine the metabolic turnover and subcellular localization of the p21 protein encoded by the EJ oncogene, the viral oncogene, and its normal cellular homolog. Pulse-labeling experiments indicated that both c-ras p21 proteins were synthesized by a very similar pathway, as was observed for the viral p21 protein of Harvey murine sarcoma virus. The pro-p21 proteins were detected in free cytosol, and the processed products were associated with plasma membrane. The intracellular half-life of p21 proteins was determined by pulse-labeling and chasing in the presence of excess unlabeled methionine. Although both p21 proteins of EJ and the normal c-ras genes which are not phosphorylated have a half-life of 20 h, the viral p21 protein of Harvey murine sarcoma virus which includes a phosphorylated form is much more stable in cells, having a half-life of 42 h, apparently due to phosphorylation.

scholarly journals On the Existence and Uniqueness of Equilibrium in the Bottleneck Model with Atomic Users

2017 ◽  
Vol 51 (3) ◽  
pp. 863-881 ◽  
Author(s):  
Hugo E. Silva ◽  
Robin Lindsey ◽  
André de Palma ◽  
Vincent A. C. van den Berg
Keyword(s):  
Existence And Uniqueness ◽  
Bottleneck Model ◽  
Uniqueness Of Equilibrium

Stimulation of Na(+)-K(+)-ATPase by thyrotropin in cultured thyroid follicular cells

1995 ◽  
Vol 268 (5) ◽  
pp. C1252-C1258 ◽  
Author(s):  
T. A. Pressley ◽  
S. C. Higham ◽  
L. A. Joson ◽  
D. W. Mercer
Keyword(s):  
Thyroid Stimulating Hormone ◽  
Follicular Cells ◽  
Hormone Synthesis ◽  
Metabolic Turnover ◽  
Striking Increase ◽  
Thyroid Follicular Cells ◽  
A Cell ◽  
Messenger System ◽  
Rat Thyroid ◽  
Stimulation Of

Thyroid-stimulating hormone (TSH; thyrotropin) produces a pleiotropic response in the thyroid gland, accelerating nearly every aspect of metabolic turnover within the follicular epithelia. We examined the effects of TSH on expression of Na(+)-K(+)-ATPase in FRTL-5 cells, a cell line derived from rat thyroid. TSH (10 mU/ml) produced a nearly twofold increase in abundance of the mRNA encoding the catalytic alpha 1-subunit within 6 h of treatment. With the four mRNAs encoding the beta 1-subunit, TSH produced a striking increase in abundance, but this regulation was discoordinate, and some species increased more than others. Similar increases in mRNA abundance were elicited by activators of the adenosine 3',5'-cyclic monophosphate second messenger system. In contrast to the alpha 1- and beta 1-mRNAs, the abundance of the mRNA encoding the beta 2-subunit was unchanged with TSH after 6 h, indicating that the effects of thyrotropin were not universal or indiscriminate. Thyrotropin also caused a 76% increase in Na(+)-K(+)-ATPase activity and a 46% increase in pump-mediated transport after 48 h. These studies suggest that the changes in metabolic turnover initiated by TSH during hormone synthesis include upregulation of the N(+)-K+ pump.

Variation in the tracheary elements in species of Coryphantha (Cacteae-Cactoideae) with contrasting morphology: the bottleneck model

2016 ◽  
Vol 39 (2) ◽  
pp. 669-678 ◽  
Author(s):  
Teresa Terrazas ◽  
Rocío Escamilla-Molina ◽  
Monserrat Vázquez-Sánchez
Keyword(s):  
Tracheary Elements ◽  
Bottleneck Model

The metabolic turnover of the major proteins of the postsynaptic density

1986 ◽  
Vol 1 (3) ◽  
pp. 221-230 ◽  
Author(s):  
G.L. Sedman ◽  
P.L. Jeffrey ◽  
L. Austin ◽  
J.A.P. Rostas
Keyword(s):  
Postsynaptic Density ◽  
Metabolic Turnover
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