Scaling up by thinking small: a perspective on the use of scale-down techniques in process design

Our philosophy of successful biotechnology transfer to industrial scale covers the comparison of complex sets of microbiological, analytical and bioengineering data from cultivations in various scales and different geometries of mixing with laboratory findings. In particular, the availability of nutrients to producing microorganism should be understood, therefore for quick scaling-up procedure of polyene antibiotics produced by Streptomyces noursei we recommend to use physiological marker as total dehydrogenase activity determination. The utility of scale-down tests for identification of process fluctuation, validation of new substrate batches and simultaneous control of inoculum quality was proved.

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Simulation and Sensitivity Analysis of Molybdenum Disulfide Nanoparticle Production Using Aspen Plus

International Journal of Chemical Engineering ◽

10.1155/2019/3953862 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Mouad Hachhach ◽

Hanane Akram ◽

Mounir Hanafi ◽

Ouafae Achak ◽

Tarik Chafik

Keyword(s):

Experimental Data ◽

Sensitivity Analysis ◽

Molybdenum Disulfide ◽

Process Design ◽

Elemental Sulfur ◽

Aspen Plus ◽

Scaling Up ◽

Synthesis Process ◽

Ammonium Heptamolybdate ◽

Nanoparticles Synthesis

The sensitivity analysis of molybdenum disulfide nanoparticles synthesis process is studied using Aspen Plus with the aim of investigating the effect of reactants’ amounts on the production of molybdenum disulfide nanoparticles. The adopted approach consists in simulating the synthesis process based on experimental data, obtained at laboratory scale followed by sensitivity analysis with respect to the following precursors: ammonium heptamolybdate, elemental sulfur, and hydrazine used as a reducing agent. The sensitivity analysis revealed that the precursors have more significant impact on the obtained amount of molybdenum disulfide compared to hydrazine. The obtained result showed that the approach adopted in the study might be of interest for further investigation of the process design and scaling-up.

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International Research-Policy Collaborations for Scaling Up Sustainable Early Development Services

PsycEXTRA Dataset ◽

10.1037/e500102015-006 ◽

2014 ◽

Author(s):

Pia Rebello Britto ◽

Hirokazu Yoshikawa ◽

June Lee ◽

Julieta Trias

Keyword(s):

Early Development ◽

International Research ◽

Research Policy ◽

Scaling Up

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The Real Leap Forward: Scaling up Poverty Reduction in China

PsycEXTRA Dataset ◽

10.1037/e646182010-001 ◽

2004 ◽

Keyword(s):

Poverty Reduction ◽

Scaling Up ◽

The Real

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Scaling up: single organisms and metagenomics

PSI Structural Genomics Knowledgebase ◽

10.1038/fa_sbkb.2010.40 ◽

2010 ◽

Author(s):

Katrin Legg

Keyword(s):

Scaling Up

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Track 6.c Introduction: Entrepreneurship in Design Education

Conference Proceedings of the Academy for Design Innovation Management ◽

10.33114/adim.2019.6c ◽

2019 ◽

Vol 2 (1) ◽

Author(s):

Bryan Howell ◽

Curt Anderson ◽

Nile Hatch ◽

Chia-Chi TENG; ◽

Neal Bangerter ◽

...

Keyword(s):

Design Education ◽

Management Strategy ◽

Business Models ◽

Scaling Up ◽

Engineering Management ◽

Significant Rise ◽

Limited Resources ◽

Multidisciplinary Teams ◽

Interdisciplinary Relationships ◽

Human Centred Design

Over that last few decades there has been a significant rise in interest for design-led entrepreneurship and innovation. This has brought about the need to expand on the principles and methods of human-centred design by incorporating knowledge from multiple disciplines, such as management, business, and entrepreneurship studies. This expansion aids designers, engineers, and marketing practitioners who strive to create innovative, meaningful and relevant services, business models and experiences. More often than not, ventures operate under very limited resources, and practitioners are often required to fulfil several roles. The concept of ‘multidisciplinary teams’ widely spread in this sphere often bears little resonance in these contexts. Designers possess valuable competencies that can have a significant impact on the venture, especially driving user and context-centred strategy and processes for the introduction, legitimization and scaling-up stages. However, engaging with these areas of practice requires skills and capacities that overlap traditional disciplinary roles. In doing so, the boundaries between design and engineering, branding and communications, cultural and behavioural insight, marketing and management strategy are blurred. As educators in design innovation, how do we explore, define and balance interdisciplinary relationships between design, engineering, management, business and entrepreneurship theories, methods, language and models of education? The purpose of the entrepreneurship in design education track is to discuss methods, models, case studies, research, insights and unexpected knowledge in benefits and limitations of design entrepreneurship education. In particular, the three papers presented in this track demonstrate different approaches to entrepreneurship and design education.

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