scholarly journals Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice

2021 ◽  
Author(s):  
Megan E. Rosa‐Caldwell ◽  
Seongkyun Lim ◽  
Wesley S. Haynie ◽  
Jacob L. Brown ◽  
David E. Lee ◽  
...  
Keyword(s):  
Disuse Atrophy ◽  
Male And Female ◽  
Female Mice

scholarly journals OXIDATIVE METABOLISM DURING THE TIME-COURSE OF DISUSE ATROPHY IN MALE AND FEMALE MICE

2020 ◽  
Vol 52 (7S) ◽  
pp. 19-19
Author(s):  
Madeline G. Amos ◽  
Megan E. Rosa-Caldwell ◽  
Wesley S. Haynie ◽  
Kirsten R. Dunlap ◽  
Seongkyun Lim ◽  
...  
Keyword(s):  
Oxidative Metabolism ◽  
Time Course ◽  
Disuse Atrophy ◽  
Male And Female ◽  
Female Mice

A subchronic oral toxicity study on medical herb extract, KIOM CRC#BP10A, in male and female mice

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
ES Cho ◽  
YJ Lee ◽  
JS Park ◽  
J Kim ◽  
NS Kim ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity ◽  
Male And Female ◽  
Female Mice ◽  
Subchronic Oral Toxicity Study ◽  
Herb Extract

Early Life Exposure to Antibiotic Alters Energy Balance during Chronic High-Fat Feeding in Adult Male and Female Mice

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1999-P ◽  
Author(s):  
HYE LIM NOH ◽  
SUJIN SUK ◽  
RANDALL H. FRIEDLINE ◽  
KUNIKAZU INASHIMA ◽  
DUY A. TRAN ◽  
...  
Keyword(s):  
Energy Balance ◽  
Adult Male ◽  
Early Life ◽  
High Fat ◽  
Male And Female ◽  
Female Mice ◽  
Early Life Exposure ◽  
Fat Feeding

Comparison of Antinociceptive Effects Induced by Kappa Opioid Agonists in Male and Female Mice

Analgesia ◽  
1999 ◽  
Vol 4 (3) ◽  
pp. 397-404 ◽  
Author(s):  
Corinne A. Patrick ◽  
M. C. Holden Ko ◽  
James H. Woods
Keyword(s):  
Kappa Opioid ◽  
Male And Female ◽  
Female Mice ◽  
Opioid Agonists ◽  
Antinociceptive Effects

Maternal separation affects the electrophysiological properties of Aδ‐fibres and nociceptive behaviours in male and female mice

2020 ◽  
Vol 80 (6) ◽  
pp. 538-546
Author(s):  
Nancy Paniagua ◽  
Rocío Girón ◽  
Carlos Goicoechea ◽  
Mª Isabel Martín‐Fontelles ◽  
Ana Bagues
Keyword(s):  
Maternal Separation ◽  
Male And Female ◽  
Electrophysiological Properties ◽  
Female Mice

scholarly journals Digging behavior discrimination test to probe burrowing and exploratory digging in male and female mice

2021 ◽  
Author(s):  
Heather L. Pond ◽  
Abigail T. Heller ◽  
Brian M. Gural ◽  
Olivia P. McKissick ◽  
Molly K. Wilkinson ◽  
...  
Keyword(s):  
Discrimination Test ◽  
Male And Female ◽  
Female Mice ◽  
Digging Behavior

scholarly journals Dissociating Representations of Time and Number in Reinforcement-Rate Learning by Deletion of the GluA1 AMPA Receptor Subunit in Mice

2021 ◽  
Vol 32 (2) ◽  
pp. 204-217
Author(s):  
Joseph M. Austen ◽  
Corran Pickering ◽  
Rolf Sprengel ◽  
David J. Sanderson
Keyword(s):  
Associative Strength ◽  
Ampa Receptor ◽  
Reinforcement Rate ◽  
Statistical Properties ◽  
Temporal Information ◽  
Receptor Subunit ◽  
Male And Female ◽  
Female Mice ◽  
Ampa Receptor Subunit ◽  
Numeric Information

Theories of learning differ in whether they assume that learning reflects the strength of an association between memories or symbolic encoding of the statistical properties of events. We provide novel evidence for symbolic encoding of informational variables by demonstrating that sensitivity to time and number in learning is dissociable. Whereas responding in normal mice was dependent on reinforcement rate, responding in mice that lacked the GluA1 AMPA receptor subunit was insensitive to reinforcement rate and, instead, dependent on the number of times a cue had been paired with reinforcement. This suggests that GluA1 is necessary for weighting numeric information by temporal information in order to calculate reinforcement rate. Sample sizes per genotype varied between seven and 23 across six experiments and consisted of both male and female mice. The results provide evidence for explicit encoding of variables by animals rather than implicit encoding via variations in associative strength.

scholarly journals Chronic non-discriminatory social defeat stress reduces effort-related motivated behaviors in male and female mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Andrew Dieterich ◽  
Tonia Liu ◽  
Benjamin Adam Samuels
Keyword(s):  
Mood Disorders ◽  
Chronic Stress ◽  
Choice Behavior ◽  
Progressive Ratio ◽  
Social Defeat ◽  
Social Defeat Stress ◽  
Male And Female ◽  
Female Mice ◽  
High Reward ◽  
Motivated Behaviors

AbstractReward and motivation deficits are prominent symptoms in many mood disorders, including depression. Similar reward and effort-related choice behavioral tasks can be used to study aspects of motivation in both rodents and humans. Chronic stress can precipitate mood disorders in humans and maladaptive reward and motivation behaviors in male rodents. However, while depression is more prevalent in women, there is relatively little known about whether chronic stress elicits maladaptive behaviors in female rodents in effort-related motivated tasks and whether there are any behavioral sex differences. Chronic nondiscriminatory social defeat stress (CNSDS) is a variation of chronic social defeat stress that is effective in both male and female mice. We hypothesized that CNSDS would reduce effort-related motivated and reward behaviors, including reducing sensitivity to a devalued outcome, reducing breakpoint in progressive ratio, and shifting effort-related choice behavior. Separate cohorts of adult male and female C57BL/6 J mice were divided into Control or CNSDS groups, exposed to the 10-day CNSDS paradigm, and then trained and tested in instrumental reward or effort-related behaviors. CNSDS reduced motivation to lever press in progressive ratio and shifted effort-related choice behavior from a high reward to a more easily attainable low reward in both sexes. CNSDS caused more nuanced impairments in outcome devaluation. Taken together, CNSDS induces maladaptive shifts in effort-related choice and reduces motivated lever pressing in both sexes.

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