scholarly journals Exogenous insulin‐like growth factor 1 attenuates cisplatin‐induced muscle atrophy in mice

2021 ◽  
Author(s):  
Hiroyasu Sakai ◽  
Maho Asami ◽  
Hiroaki Naito ◽  
Satoko Kitora ◽  
Yuta Suzuki ◽  
...  
Keyword(s):  
Growth Factor ◽  
Muscle Atrophy ◽  
Insulin Like Growth Factor ◽  
Exogenous Insulin

scholarly journals Local insulin-like growth factor I prevents sepsis-induced muscle atrophy

Metabolism ◽  
2009 ◽  
Vol 58 (6) ◽  
pp. 787-797 ◽  
Author(s):  
Gerald Nystrom ◽  
Anne Pruznak ◽  
Danuta Huber ◽  
Robert A. Frost ◽  
Charles H. Lang
Keyword(s):  
Growth Factor ◽  
Muscle Atrophy ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

Insulin-like growth factor I slows the rate of denervation induced skeletal muscle atrophy

2005 ◽  
Vol 15 (2) ◽  
pp. 139-146 ◽  
Author(s):  
Thea Shavlakadze ◽  
Jason D. White ◽  
Marilyn Davies ◽  
Joseph F.Y. Hoh ◽  
Miranda D. Grounds
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Muscle Atrophy ◽  
Skeletal Muscle Atrophy ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

Exogenous insulin-like growth factor 2 administration enhances memory consolidation and persistence in a time-dependent manner

2015 ◽  
Vol 1622 ◽  
pp. 466-473 ◽  
Author(s):  
Younghwan Lee ◽  
Young Woo Lee ◽  
Qingtao Gao ◽  
Younghwa Lee ◽  
Hyung Eun Lee ◽  
...  
Keyword(s):  
Growth Factor ◽  
Memory Consolidation ◽  
Time Dependent ◽  
Dependent Manner ◽  
Insulin Like Growth Factor ◽  
Exogenous Insulin

THE EFFECTS OF INSULIN-LIKE GROWTH FACTOR-1 AND NERVE GROWTH FACTOR ON DENERVATED MUSCLE ATROPHY

2001 ◽  
Vol 05 (03) ◽  
pp. 193-203 ◽  
Author(s):  
Boonsin Buranapanitkit ◽  
Zhuqing Qu ◽  
Morey M. Moreland ◽  
Alan Geater ◽  
George Somogyi ◽  
...  
Keyword(s):  
Growth Factors ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Muscle Atrophy ◽  
Interstitial Fibrosis ◽  
Insulin Like Growth Factor ◽  
Denervated Muscle ◽  
Nerve Growth ◽  
Wet Weight ◽  
The Mean

The effects of growth factors on denervated muscle atrophy in mouse gastrocnemius muscle were studied by morphometric, physiologic and histologic methods. Fifteen mice were randomized into three groups: intact, denervated-insulin-like growth factor-1-treated (D-IGF-1) and denervated-nerve growth factor-treated (D-NGF). In denervated animals, the left sides were used as a control by injecting balanced salt solution (HBSS), while the right sides were injected with growth factors. The mean wet weight and the mean wet weight/body weight were significantly higher in D-IGF-1 muscles compared to the D-NGF and D-HBSS muscles, but were not different from the muscle of intact controls. Physiologic testing showed that the mean maximal tetanic twitch strength and the mean maximal fast twitch strength were also significantly higher in the D-IGF-1 muscles than in the D-NGF and D-HBSS muscles. Mean time-to-peak was significantly only decreased in the D-NGF muscles. Histological studies found that the mean percentage of type 2 fiber was significantly higher in D-NGF muscles. The types I and II mean diameters in the D-IGF-1 muscles were larger than in the D-NGF and D-HBSS muscles, but all denervated muscles had higher interstitial fibrosis than the intact controls. In conclusion, we show that IGF-1 can effectively retard denervated muscle atrophy by increasing types I and II fibre muscle diameter. However, IGF-1 cannot prevent interstitial fibrosis in the denervated muscle.

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