scholarly journals Serum amyloid A1 mediates myotube atrophy via Toll‐like receptors

2019 ◽  
Vol 11 (1) ◽  
pp. 103-119 ◽  
Author(s):  
Alexander Hahn ◽  
Melanie Kny ◽  
Cristina Pablo‐Tortola ◽  
Mihail Todiras ◽  
Michael Willenbrock ◽  
...  
Keyword(s):  
Serum Amyloid ◽  
Toll Like Receptors ◽  
Serum Amyloid A1

Serum Amyloid A, Serum Amyloid A1 and Haptoglobin in pregnant mares and their fetuses after experimental induction of placentitis

2021 ◽  
pp. 106766
Author(s):  
Y. Linhares Boakari ◽  
A. Esteller-Vico ◽  
S. Loux ◽  
H. El-Sheikh Ali ◽  
C. Barbosa Fernandes ◽  
...  
Keyword(s):  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Experimental Induction ◽  
Serum Amyloid A1

scholarly journals Serum Amyloid A1/Toll-Like Receptor-4 Axis, an Important Link between Inflammation and Outcome of TBI Patients

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 599
Author(s):  
Víctor Farré-Alins ◽  
Alejandra Palomino-Antolín ◽  
Paloma Narros-Fernández ◽  
Ana Belen Lopez-Rodriguez ◽  
Céline Decouty-Perez ◽  
...  
Keyword(s):  
Injury Severity ◽  
White Blood Cells ◽  
Serum Amyloid ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Important Link ◽  
Tlr4 Mrna ◽  
Serum Amyloid A1

Traumatic brain injury (TBI) is one of the leading causes of mortality and disability worldwide without any validated biomarker or set of biomarkers to help the diagnosis and evaluation of the evolution/prognosis of TBI patients. To achieve this aim, a deeper knowledge of the biochemical and pathophysiological processes triggered after the trauma is essential. Here, we identified the serum amyloid A1 protein-Toll-like receptor 4 (SAA1-TLR4) axis as an important link between inflammation and the outcome of TBI patients. Using serum and mRNA from white blood cells (WBC) of TBI patients, we found a positive correlation between serum SAA1 levels and injury severity, as well as with the 6-month outcome of TBI patients. SAA1 levels also correlate with the presence of TLR4 mRNA in WBC. In vitro, we found that SAA1 contributes to inflammation via TLR4 activation that releases inflammatory cytokines, which in turn increases SAA1 levels, establishing a positive proinflammatory loop. In vivo, post-TBI treatment with the TLR4-antagonist TAK242 reduces SAA1 levels, improves neurobehavioral outcome, and prevents blood–brain barrier disruption. Our data support further evaluation of (i) post-TBI treatment in the presence of TLR4 inhibition for limiting TBI-induced damage and (ii) SAA1-TLR4 as a biomarker of injury progression in TBI patients.

scholarly journals Hepatic Expression of Serum Amyloid A1 Is Induced by Traumatic Brain Injury and Modulated by Telmisartan

2015 ◽  
Vol 185 (10) ◽  
pp. 2641-2652 ◽  
Author(s):  
Sonia Villapol ◽  
Dmitry Kryndushkin ◽  
Maria G. Balarezo ◽  
Ashley M. Campbell ◽  
Juan M. Saavedra ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Serum Amyloid ◽  
Hepatic Expression ◽  
Serum Amyloid A1

scholarly journals Serum Amyloid A1 Induces Classically Activated Macrophages: A Role for Enhanced Fibril Formation

2021 ◽  
Vol 12 ◽  
Author(s):  
Ann-Kathrin Gaiser ◽  
Shanna Bauer ◽  
Stephanie Ruez ◽  
Karlheinz Holzmann ◽  
Marcus Fändrich ◽  
...  
Keyword(s):  
Amyloid Fibrils ◽  
Intervention Strategy ◽  
Serum Amyloid ◽  
Macrophage Phenotype ◽  
Aa Amyloidosis ◽  
Inflammatory Conditions ◽  
Serum Amyloid A1 ◽  
And Function

AA amyloidosis belongs to the group of amyloid diseases which can follow chronic inflammatory conditions of various origin. The disease is characterized by the deposition of insoluble amyloid fibrils formed by serum amyloid A1 (SAA1) leading eventually to organ failure. Macrophages are intimately involved in the fibrillogenesis as well as in the clearance of amyloid fibrils. In vivo, macrophages may occur as classically (M1) or alternatively activated (M2) macrophages. We investigate here how SAA1 might affect the macrophage phenotype and function. Gene microarray analysis revealed upregulation of 64 M1-associated genes by SAA1. M1-like polarization was further confirmed by the expression of the M1-marker MARCO, activation of the NF-κB transcription factor, and secretion of the M1-cytokines TNF-α, IL-6, and MCP-1. Additionally, we demonstrate here that M1-polarized macrophages exhibit enhanced fibrillogenic activity towards SAA1. Based on our data, we propose reconsideration of the currently used cellular amyloidosis models towards an in vitro model employing M1-polarized macrophages. Furthermore, the data suggest macrophage repolarization as potential intervention strategy in AA amyloidosis.

Serum amyloid A1 can be a novel biomarker for evaluating the presence and severity of acute coronary syndrome

2020 ◽  
Vol 85 ◽  
pp. 27-32
Author(s):  
Cheng Chang ◽  
Yilong Pan ◽  
Hongjiao Du ◽  
Xiao Wang ◽  
Xiaodong Li
Keyword(s):  
Acute Coronary Syndrome ◽  
Serum Amyloid ◽  
Coronary Syndrome ◽  
Serum Amyloid A1

scholarly journals Purification and Identification of a Tissue-specific Repressor Involved in Serum Amyloid A1 Gene Expression

1999 ◽  
Vol 274 (52) ◽  
pp. 37154-37160 ◽  
Author(s):  
Yongsheng Ren ◽  
Shrikanth A. G. Reddy ◽  
Warren S.-L. Liao
Keyword(s):  
Gene Expression ◽  
Serum Amyloid ◽  
Tissue Specific ◽  
Serum Amyloid A1

Abstract LB-428: Upregulation of serum amyloid A1 (SAA 1) gene is associated with ulcerative colitis-related colon cancer

2011 ◽  
Author(s):  
Michael W. Schaffer ◽  
Joan C. Smith ◽  
Tanusri Ghosh Roy ◽  
Harold L. Moses ◽  
Samuel E. Adunyah ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Colon Cancer ◽  
Serum Amyloid ◽  
Serum Amyloid A1

Abstract 3998: The role of serum amyloid A1 (SAA1) in nasopharyngeal carcinoma (NPC)

2012 ◽  
Author(s):  
Hong Lok Lung ◽  
Arthur Kwok Leung Cheung ◽  
Yeung Man Chung ◽  
Edison Tak-Bun Liu ◽  
Daniel Chua ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Serum Amyloid ◽  
Serum Amyloid A1

Serum amyloid A1 alleles and plasma concentrations of serum amyloid A

Amyloid ◽  
1999 ◽  
Vol 6 (3) ◽  
pp. 199-204 ◽  
Author(s):  
Toshiyuki Yamada ◽  
Atsufumi Wada ◽  
Yoshihisa Itoh ◽  
Kouichi Itoh
Keyword(s):  
Serum Amyloid A ◽  
Plasma Concentrations ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Serum Amyloid A1
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