scholarly journals Effectiveness of a multimodal intervention in functionally impaired older people with type 2 diabetes mellitus

2019 ◽  
Vol 10 (4) ◽  
pp. 721-733 ◽  
Author(s):  
Leocadio Rodriguez‐Mañas ◽  
Olga Laosa ◽  
Bruno Vellas ◽  
Giuseppe Paolisso ◽  
Eva Topinkova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Older People ◽  
Multimodal Intervention ◽  
Functionally Impaired

scholarly journals 5.1 The Role of Blood Pressure, Aortic Stiffness, and Haemodynamics in Brain Health in Older People with Type 2 Diabetes Mellitus

2020 ◽  
Vol 25 (Supplement 1) ◽  
pp. S37
Author(s):  
Christopher Karayiannis ◽  
Chris Moran ◽  
Richard Beare ◽  
James Sharman ◽  
Thanh Phan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Older People ◽  
Aortic Stiffness ◽  
Brain Health

scholarly journals P4-343: THE ROLE OF BLOOD PRESSURE, AORTIC STIFFNESS, AND HAEMODYNAMICS IN BRAIN HEALTH IN OLDER PEOPLE WITH TYPE 2 DIABETES MELLITUS

2019 ◽  
Vol 15 ◽  
pp. P1428-P1429
Author(s):  
Christopher C. Karayiannis ◽  
Chris Moran ◽  
Richard Beare ◽  
James Sharman ◽  
Thanh G. Phan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Older People ◽  
Aortic Stiffness ◽  
Brain Health

scholarly journals Identification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study

Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 199 ◽  
Author(s):  
Riccardo Calvani ◽  
Leocadio Rodriguez-Mañas ◽  
Anna Picca ◽  
Federico Marini ◽  
Alessandra Biancolillo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Older Adults ◽  
Amino Acids ◽  
Type 2 Diabetes Mellitus ◽  
Older Persons ◽  
Functionally Impaired ◽  
Frail Older Persons ◽  
Amino Acids And Derivatives

Diabetes and frailty are highly prevalent conditions that impact the health status of older adults. Perturbations in protein/amino acid metabolism are associated with both functional impairment and type 2 diabetes mellitus (T2DM). In the present study, we compared the concentrations of a panel of circulating 37 amino acids and derivatives between frail/pre-frail older adults with T2DM and robust non-diabetic controls. Sixty-six functionally impaired older persons aged 70+ with T2DM and 30 age and sex-matched controls were included in the analysis. We applied a partial least squares-discriminant analysis (PLS-DA)-based analytical strategy to characterize the metabotype of study participants. The optimal complexity of the PLS-DA model was found to be two latent variables. The proportion of correct classification was 94.1 ± 1.9% for frail/pre-frail persons with T2DM and 100% for control participants. Functionally impaired older persons with T2DM showed higher levels of 3-methyl histidine, alanine, arginine, glutamic acid, ethanolamine sarcosine, and tryptophan. Control participants had higher levels of ornithine and taurine. These findings indicate that a specific profile of amino acids and derivatives characterizes pre-frail/frail older persons with T2DM. The dissection of these pathways may provide novel insights into the metabolic perturbations involved in the disabling cascade in older persons with T2DM.

The “Metabolic biomarkers of frailty in older people with type 2 diabetes mellitus” (MetaboFrail) study: Rationale, design and methods

2020 ◽  
Vol 129 ◽  
pp. 110782 ◽  
Author(s):  
Riccardo Calvani ◽  
Leocadio Rodriguez-Mañas ◽  
Anna Picca ◽  
Federico Marini ◽  
Alessandra Biancolillo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Older People ◽  
Metabolic Biomarkers ◽  
Design And Methods

scholarly journals The prevalence of type 2 diabetes mellitus among older people in Africa: a systematic review study protocol

BMJ Open ◽  
2014 ◽  
Vol 4 (6) ◽  
pp. e004747-e004747 ◽  
Author(s):  
M. Werfalli ◽  
A. Musekiwa ◽  
M. E. Engel ◽  
I. Ross ◽  
A. P. Kengne ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Older People ◽  
Study Protocol ◽  
Review Study
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