scholarly journals Fatty acid-binding protein 4 regulates fatty infiltration after rotator cuff tear by hypoxia-inducible factor 1 in mice

2017 ◽  
Vol 8 (5) ◽  
pp. 839-850 ◽  
Author(s):  
Yong-Soo Lee ◽  
Ja-Yeon Kim ◽  
Kyung-Soo Oh ◽  
Seok Won Chung
Keyword(s):  
Fatty Acid ◽  
Rotator Cuff ◽  
Rotator Cuff Tear ◽  
Fatty Acid Binding Protein ◽  
Fatty Infiltration ◽  
Hypoxia Inducible Factor ◽  
Fatty Acid Binding ◽  
Hypoxia Inducible Factor 1 ◽  
Acid Binding Protein ◽  
Cuff Tear

scholarly journals Fatty-acid-induced FABP5/HIF-1 reprograms lipid metabolism and enhances the proliferation of liver cancer cells

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Jieun Seo ◽  
Do-Won Jeong ◽  
Jong-Wan Park ◽  
Kwang-Woong Lee ◽  
Junji Fukuda ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Lipid Metabolism ◽  
Fatty Acid Binding Protein ◽  
Hypoxia Inducible Factor ◽  
Interacting Proteins ◽  
Proteomics Analysis ◽  
Fatty Acid Binding ◽  
Binding Partner ◽  
Hypoxia Inducible Factor 1 ◽  
Cancer Cell Survival

Abstract Hypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor essential for cancer cell survival. The reprogramming of lipid metabolism has emerged as a hallmark of cancer, yet the relevance of HIF-1α to this process remains elusive. In this study, we profile HIF-1α-interacting proteins using proteomics analysis and identify fatty acid-binding protein 5 (FABP5) as a critical HIF-1α-binding partner. In hepatocellular carcinoma (HCC) tissues, both FABP5 and HIF-1α are upregulated, and their expression levels are associated with poor prognosis. FABP5 enhances HIF-1α activity by promoting HIF-1α synthesis while disrupting FIH/HIF-1α interaction at the same time. Oleic-acid treatment activates the FABP5/HIF-1α axis, thereby promoting lipid accumulation and cell proliferation in HCC cells. Our results indicate that fatty-acid-induced FABP5 upregulation drives HCC progression through HIF-1-driven lipid metabolism reprogramming.

Calcium-dependent release of adipocyte fatty acid binding protein from human adipocytes

2014 ◽  
Vol 122 (03) ◽  
Author(s):  
I Schlottmann ◽  
M Ehrhart-Bornstein ◽  
M Wabitsch ◽  
SR Bornstein ◽  
V Lamounier-Zepter
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Human Adipocytes ◽  
Fatty Acid Binding ◽  
Calcium Dependent ◽  
Acid Binding Protein

Biochemical and Histochemical Studies of Liver Fatty Acid Binding Protein in Alcohol-Treated Rats.

1993 ◽  
Vol 14 (3) ◽  
pp. 171-181
Author(s):  
Shigeya WATANABE ◽  
Yoshio WAKATSUKI ◽  
Hideyuki YOSHIOKA ◽  
Masami INADA ◽  
Teruo ONO ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Liver Fatty Acid ◽  
Fatty Acid Binding ◽  
Acid Binding Protein
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