Effect of Agomelatine and Fluoxetine on HAM-D Score, Serum Brain-Derived Neurotrophic Factor, and Tumor Necrosis Factor-αLevel in Patients With Major Depressive Disorder With Severe Depression

2017 ◽  
Vol 57 (12) ◽  
pp. 1519-1526 ◽  
Author(s):  
Keshav Gupta ◽  
Rachna Gupta ◽  
M.S. Bhatia ◽  
A.K. Tripathi ◽  
Lalit K. Gupta
Keyword(s):  
Major Depressive Disorder ◽  
Tumor Necrosis Factor ◽  
Depressive Disorder ◽  
Neurotrophic Factor ◽  
Tumor Necrosis ◽  
Severe Depression ◽  
Brain Derived Neurotrophic Factor ◽  
Major Depressive ◽  
Necrosis Factor

scholarly journals Increased soluble tumor necrosis factor-α receptors in patients with major depressive disorder

2009 ◽  
Vol 63 (2) ◽  
pp. 202-208 ◽  
Author(s):  
Rodrigo Grassi-Oliveira ◽  
Elisa Brietzke ◽  
Júlio C. Pezzi ◽  
Rodrigo P. Lopes ◽  
Antonio L. Teixeira ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Tumor Necrosis Factor ◽  
Depressive Disorder ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Major Depressive ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Low tumor necrosis factor-α levels predict symptom reduction during electroconvulsive therapy in major depressive disorder

2018 ◽  
Vol 8 (4) ◽  
pp. e00933 ◽  
Author(s):  
Annamari Sorri ◽  
Kaija Järventausta ◽  
Olli Kampman ◽  
Kai Lehtimäki ◽  
Minna Björkqvist ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Tumor Necrosis Factor ◽  
Depressive Disorder ◽  
Electroconvulsive Therapy ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Symptom Reduction ◽  
Major Depressive ◽  
Factor Α ◽  
Necrosis Factor

Associations of Tumor Necrosis Factor–α G-308A (rs1800629) Gene Polymorphisms with Major Depressive Disorder

2021 ◽  
Vol 19 (7) ◽  
pp. 133-136
Author(s):  
Aamal Muhsen Kadhum ◽  
Bayader M. Abd Al–Kadim ◽  
Thanaa Chasib Kareem ◽  
Ali Ahmed Nayyef ◽  
Mona N. Al-Terehi
Keyword(s):  
Major Depressive Disorder ◽  
Tumor Necrosis Factor ◽  
Depressive Disorder ◽  
Gene Polymorphisms ◽  
Tumor Necrosis ◽  
Control Group ◽  
Major Depressive ◽  
Allele Distribution ◽  
Tnf Α ◽  
Necrosis Factor

Pro-inflammatory cytokine polymorphisms like Tumor Necrosis Factor- (TNF), has been found associated to severe depressive disorder (MDD). The Pro-inflammatory cytokines tumor necrosis factor (TNF-α) G-308A (rs1800629) have been discovered to have an important role in the pathophysiology of depressive disorders and the mechanism of antidepressant treatment. The present study aims to study TNF-α gene polymorphisms in Major depressive disorder using allele specific PCR. The results show that family history are non- significant different between patients and control group (0.6346) and also there was non- significant different in BMI (0.3417), The genotyping data show tow alleles and three genotyping (AG, GG, AA) the statically analysis show non-significant differences between patients and controls groups (0.095, 0.800) for GG, AA and GA respectively with more frequent of GA in patients than control group, the G allele was less frequent in patient than control while A allele was more frequent in patients than control group in significant differences (0.0001). It can be concluded that TNF genotyping didn’t impact in the Major depressive disorder but the allele distribution may have potential role in MDD patients.

S94. Tumor Necrosis Factor Alpha in Major Depressive Disorder: Effects of Anti-Depressant Treatments

2019 ◽  
Vol 85 (10) ◽  
pp. S333
Author(s):  
Conrad Stasieluk ◽  
Edwin Meresh ◽  
Debra Hoppensteadt ◽  
Jawed Fareed ◽  
James Sinacore ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Tumor Necrosis Factor ◽  
Depressive Disorder ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Major Depressive ◽  
Necrosis Factor Alpha ◽  
Disorder Effects ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Serum Levels of Tumor Necrosis Factor-α and Loudness Dependence of Auditory Evoked Potentials at Pretreatment and Posttreatment in Patients with Major Depressive Disorder

2019 ◽  
Vol 9 (10) ◽  
pp. 253
Author(s):  
Bun-Hee Lee ◽  
Young-Min Park ◽  
Seung-Hwan Lee ◽  
Miseon Shim
Keyword(s):  
Major Depressive Disorder ◽  
Tumor Necrosis Factor ◽  
Depressive Disorder ◽  
Tumor Necrosis ◽  
Auditory Evoked Potentials ◽  
Major Depressive ◽  
Tnf Α ◽  
Loudness Dependence ◽  
Α Level ◽  
Necrosis Factor

Background: Proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), are associated with the pathophysiology of major depressive disorder (MDD). Several studies have reported that increased TNF-α might be associated with tryptophan depletion, which eventually could result in MDD. However, other studies revealed that TNF-α increased serotonin firing in raphe. Therefore, whether TNF-α increases or decreases serotonin activity remains unclear. Here, we aimed to determine the relationship between serum TNF-α level and central serotonergic activity using the loudness dependence of auditory evoked potentials (LDAEP) and standardized low-resolution brain electromagnetic tomography (sLORETA), as well as to evaluate the effects of antidepressants on TNF-α levels. Methods: LDAEP, serum TNF-α level, and depression severity were measured in 64 MDD outpatients pre and post 3 months of treatment. Results: Pretreatment TNF-α levels were negatively correlated with the pretreatment N1 sLORETA-LDAEP, P2 sLORETA-LDAEP, and N1/P2 sLORETA-LDAEP (p < 0.05). In multiple regression analysis for N1/P2 sLORETA-LDAEP, lower N1/P2 sLORETA-LDAEP was significantly related to higher TNF-α (CE = −0.047, p = 0.017) when all subjects were dichotomized based on the median TNF-α level (7.16 pg/mL) into pretreatment low- and high-TNF-α groups. In addition, the pretreatment Beck Depression Inventory, P2 LDAEP, and N1/P2 sLORETA-LDAEP were greater in the high-TNF-α groups than in the low-TNF-α groups (p < 0.05). Moreover, the posttreatment TNF-α level was significantly decreased compared to the pretreatment TNF-α level (z = −2.581, p = 0.01). However, the posttreatment TNF-α levels were not associated with posttreatment LDAEP. Conclusions: Higher TNF-α level is associated with decreased LDAEP, which could indicate compensatory elevation of central serotonin activity in outpatients with MDD, although this effect disappeared and TNF-α level was reduced after three months of antidepressant treatment.

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