scholarly journals Model-Based Evaluation of Exenatide Effects on the QT Interval in Healthy Subjects Following Continuous IV Infusion

2017 ◽  
Vol 57 (8) ◽  
pp. 956-965 ◽  
Author(s):  
Brenda Cirincione ◽  
Frank LaCreta ◽  
Philip Sager ◽  
Donald E. Mager
Keyword(s):  
Qt Interval ◽  
Healthy Subjects ◽  
Model Based

Aclidinium Bromide, a Long-Acting Antimuscarinic, Does Not Affect QT Interval in Healthy Subjects

2011 ◽  
Vol 51 (6) ◽  
pp. 923-932 ◽  
Author(s):  
Kenneth C. Lasseter ◽  
Jordi Aubets ◽  
Ferran Chuecos ◽  
Esther Garcia Gil
Keyword(s):  
Qt Interval ◽  
Healthy Subjects ◽  
Aclidinium Bromide ◽  
Long Acting

Early repolarization and short QT interval in healthy subjects

Heart Rhythm ◽  
2012 ◽  
Vol 9 (8) ◽  
pp. 1265-1271 ◽  
Author(s):  
Gopi Krishna Panicker ◽  
Deepak Manohar ◽  
Dilip R. Karnad ◽  
Vaibhav Salvi ◽  
Snehal Kothari ◽  
...  
Keyword(s):  
Qt Interval ◽  
Healthy Subjects ◽  
Early Repolarization

scholarly journals Entropy Analysis of RR and QT Interval Variability during Orthostatic and Mental Stress in Healthy Subjects

Entropy ◽  
2014 ◽  
Vol 16 (12) ◽  
pp. 6384-6393 ◽  
Author(s):  
Mathias Baumert ◽  
Barbora Czippelova ◽  
Anand Ganesan ◽  
Martin Schmidt ◽  
Sebastian Zaunseder ◽  
...  
Keyword(s):  
Qt Interval ◽  
Mental Stress ◽  
Healthy Subjects ◽  
Entropy Analysis ◽  
Qt Interval Variability

scholarly journals Correction to: Ibrutinib does not prolong the corrected QT interval in healthy subjects: results from a thorough QT study

2017 ◽  
Vol 81 (2) ◽  
pp. 423-423
Author(s):  
Jan de Jong ◽  
Peter Hellemans ◽  
James Juhui Jiao ◽  
Yuhan Huang ◽  
Sofie Mesens ◽  
...  
Keyword(s):  
Qt Interval ◽  
Healthy Subjects ◽  
Corrected Qt Interval ◽  
Thorough Qt Study

scholarly journals Comparison of methods of chemical loop gain measurement during tidal ventilation in awake healthy subjects

2018 ◽  
Vol 125 (6) ◽  
pp. 1681-1692 ◽  
Author(s):  
Plamen Bokov ◽  
Boris Matrot ◽  
Jorge Gallego ◽  
Christophe Delclaux
Keyword(s):  
Healthy Subjects ◽  
Minute Ventilation ◽  
Loop Gain ◽  
Tidal Breathing ◽  
Medium Frequency ◽  
Model Based ◽  
Gain Measurement ◽  
Explained Variance ◽  
End Tidal ◽  
Constrained Models

The loop gain (LG) is defined as the ratio of a ventilatory response over the perturbation in ventilation, and it is used to analyze ventilatory control stability. The LG can be derived from minute ventilation (V̇e), end-tidal Pco2 ([Formula: see text]), and end-tidal Po2 ([Formula: see text]) values. Several methods of LG assessment have been developed, which have never been compared. We evaluated the computability, the short-term repeatability, and the agreement of six published (or slightly modified) models for LG determination. These models included three unconstrained autoregressive models, univariate (V̇e), bivariate (V̇e, [Formula: see text]), and trivariate (V̇e, [Formula: see text], and [Formula: see text]), and three analytical transfer function constrained models based on V̇e, V̇e and CO2-sensitivity, and V̇e and central and peripheral CO2 sensitivities, respectively. The models were tested with tidal breathing data in 37 awake healthy subjects (median age 35 yr; 23 women, 14 men). Modeling failed in 11, 0, and 0 subjects for the three unconstrained models, respectively, and 4, 1, and 9 subjects for the three constrained models, respectively. Bland and Altman analyses of the LG values in the medium frequency range of two separate recordings demonstrated good repeatability for four models, excluding univariate and trivariate unconstrained models. The four repeatable models gave LG values that were in agreement (medium frequency LG, median 0.100–0.210), although the constrained model based on V̇e systematically overestimated LG values. The variances explained by these models were ∼20%. In conclusion, model-based analyses of tidal breathing were performed with different approaches that gave comparable results for chemical LG and explained variance. NEW & NOTEWORTHY Several methods of chemical loop gain measurement have been published but never compared. We show that a better repeatability is obtained with analytical constrained models compared with autoregressive unconstrained models and that the repeatable models gave comparable results of loop gain, even if the calculation based on ventilation-only recording gave higher values than those obtained with both ventilation and end-tidal Pco2 recording. The explained variance of ventilation was similar whatever the model.

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