Lack of a clinically important pharmacokinetic interaction between sofosbuvir or ledipasvir and hormonal oral contraceptives norgestimate/ethinyl estradiol in HCV-Uninfected female subjects

2014 ◽  
Vol 54 (11) ◽  
pp. 1290-1298 ◽  
Author(s):  
P. German ◽  
L. Moorehead ◽  
Phillip Pang ◽  
M. Vimal ◽  
A. Mathias
Keyword(s):  
Oral Contraceptives ◽  
Ethinyl Estradiol ◽  
Pharmacokinetic Interaction ◽  
Uninfected Female ◽  
Female Subjects

Decreased Levels of Histidine-Rich Glycoprotein (HRG) and Increased Levels of Free Plasminogen in Women on Oral Contraceptives Low in Estrogen

1982 ◽  
Vol 48 (03) ◽  
pp. 283-285 ◽  
Author(s):  
Jørgen Jespersen ◽  
Cornelis Kluft
Keyword(s):  
Oral Contraceptives ◽  
Ethinyl Estradiol ◽  
Relative Increase ◽  
Normal Group ◽  
Plasma Samples ◽  
Normal Women ◽  
Made In

SummaryDeterminations by immunologic methods of histidine-rich glycoprotein (HRG) and plasminogen, were made in plasma samples collected during one normal or hormone induced cycle in 15 young, normal women and in 11 women using oral contraceptives with 30 μg ethinyl estradiol and 150 μg levo-norgestrel. The hormone group showed an increase in plasminogen level to about 150% of normal, while the concentration of HRG was decreased to about 75% of normal. This resulted in a considerable relative increase in the concentration of free plasminogen in the hormone group (calculated from the equilibrium: HRG·plasminogen ⇌ HRG + plasminogen, using KD = 1.0 μM), representing a doubling of that in the normal group. Hence, more plasminogen is available for binding to fibrin and activation in the hormone group.

Combined oral contraceptives and treatment of new coronavirus infection (COVID-19): aspects of drug interactions

2021 ◽  
Vol 19 (1) ◽  
pp. 149-158
Author(s):  
O.A. Limanova ◽  
◽  
L.E. Fedotova ◽  
O.A. Gromova ◽  
◽  
...  
Keyword(s):  
Drug Interactions ◽  
Oral Contraceptives ◽  
Ethinyl Estradiol ◽  
Antihypertensive Drugs ◽  
Efficacy And Safety ◽  
Antiinflammatory Drugs ◽  
Combined Oral Contraceptives ◽  
Chlormadinone Acetate ◽  
Coronavirus Infection ◽  
Oral Hypoglycemic Drugs

This article discusses the problem of drug interactions between combined oral contraceptives on the example of Belara® (30 μg of ethinyl estradiol + 2 mg of chlormadinone acetate; Gedeon Richter, Hungary) and medications recommended for the treatment of new coronavirus infection (COVID-19) and concomitant disorders at the pharmacodynamic and pharmacokinetic levels with an assessment of the efficacy and safety of therapy for females. We described safe, potentially dangerous, and dangerous combinations of these drugs. Key words: new coronavirus infection (CAVID-19), combined oral contraceptives, antiviral drugs, antibacterial drugs, antiinflammatory drugs, anticoagulants, migraine drugs, antihypertensive drugs, oral hypoglycemic drugs, essential micronutrients, pharmacodynamic and pharmacokinetic interactions

scholarly journals Pharmacokinetic Interaction Between Nevirapine and Ethinyl Estradiol/Norethindrone When Administered Concurrently to HIV-Infected Women

2002 ◽  
Vol 29 (5) ◽  
pp. 471-477 ◽  
Author(s):  
Donna Mildvan ◽  
Robert Yarrish ◽  
Ann Marshak ◽  
Herbert W. Hutman ◽  
Marita McDonough ◽  
...  
Keyword(s):  
Ethinyl Estradiol ◽  
Pharmacokinetic Interaction

Conventional vs. Extended-Cycle Oral Contraceptives on the Quality of Sexual Life: Comparison between Two Regimens Containing 3mg Drospirenone and 20µg Ethinyl Estradiol

2011 ◽  
Vol 8 (5) ◽  
pp. 1478-1485 ◽  
Author(s):  
Salvatore Caruso ◽  
Marco Iraci Sareri ◽  
Carmela Agnello ◽  
Mattea Romano ◽  
Lucia Lo Presti ◽  
...  
Keyword(s):  
Oral Contraceptives ◽  
Ethinyl Estradiol ◽  
Sexual Life ◽  
Extended Cycle
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