scholarly journals Pharmacokinetics and Safety of Ferric Pyrophosphate Citrate Intravenous: Equivalence to Administration via Dialysate

2021 ◽  
Author(s):  
Thomas Marbury ◽  
Fred Heuveln ◽  
Eric Horst ◽  
Raymond D Pratt
Keyword(s):  
Ferric Pyrophosphate ◽  
Ferric Pyrophosphate Citrate

scholarly journals Physicochemical characterization of ferric pyrophosphate citrate

BioMetals ◽  
2018 ◽  
Vol 31 (6) ◽  
pp. 1091-1099
Author(s):  
Ajay Gupta ◽  
Raymond Pratt ◽  
Bhoopesh Mishra
Keyword(s):  
Physicochemical Characterization ◽  
Ferric Pyrophosphate ◽  
Ferric Pyrophosphate Citrate

scholarly journals Ferric pyrophosphate citrate (Triferic™) administration via the dialysate maintains hemoglobin and iron balance in chronic hemodialysis patients

2015 ◽  
Vol 30 (12) ◽  
pp. 2019-2026 ◽  
Author(s):  
Steven N. Fishbane ◽  
Ajay K. Singh ◽  
Serge H. Cournoyer ◽  
Kailash K. Jindal ◽  
Paolo Fanti ◽  
...  
Keyword(s):  
Hemodialysis Patients ◽  
Chronic Hemodialysis ◽  
Ferric Pyrophosphate ◽  
Ferric Pyrophosphate Citrate

scholarly journals Pharmacokinetics of Ferric Pyrophosphate Citrate, a Novel Iron Salt, Administered Intravenously to Healthy Volunteers

2016 ◽  
Vol 57 (3) ◽  
pp. 312-320 ◽  
Author(s):  
Raymond D. Pratt ◽  
Dorine W. Swinkels ◽  
T. Alp Ikizler ◽  
Ajay Gupta
Keyword(s):  
Healthy Volunteers ◽  
Iron Salt ◽  
Ferric Pyrophosphate ◽  
Ferric Pyrophosphate Citrate

scholarly journals Ferric pyrophosphate citrate: interactions with transferrin

BioMetals ◽  
2018 ◽  
Vol 31 (6) ◽  
pp. 1081-1089 ◽  
Author(s):  
Raymond Pratt ◽  
Garry J. Handelman ◽  
Thomas E. Edwards ◽  
Ajay Gupta
Keyword(s):  
Ferric Pyrophosphate ◽  
Ferric Pyrophosphate Citrate

scholarly journals Analytical Methods for Ionic Profile of Dialysate Iron Therapy Drug Ferric Pyrophosphate Citrate By Ion Chromatography using Suppressed and Non-Suppressed Conductivity Detection

2020 ◽  
Vol 32 (6) ◽  
pp. 1393-1398
Keyword(s):  
Metal Ion ◽  
Iron Supplementation ◽  
Exchange Chromatography ◽  
Drug Molecule ◽  
Conductivity Detection ◽  
Ferric Pyrophosphate ◽  
Ferric Pyrophosphate Citrate ◽  
Suppressed Conductivity Detection ◽  
Pharmaceutical Industries ◽  
Gradient Separation

In present study, ionic profile of pharmaceutical drug molecule ferric pyrophosphate citrate by ion exchange chromatography using conductivity detection was carried out. Ferric pyrophosphate citrate is an iron organic complex used for hemodialysis for the chronic kidney disease patients. The drug is used as iron supplementation to balance the iron loss during the dialysis for the kidney affected patients. Anions, cation and metal ion were analyzed by ion chromatographic method. Relevant anions sulphate, phosphate, citrate and pyrophosphate were analyzed by suppressed conductivity detection. Both isocratic and gradient separation methods were developed for the anions analysis. Cation sodium was analyzed by non-suppressed conductivity detection. Metal iron was determined by direct conductivity detection. All the analyses were done covering selectivity, precision, linearity and accuracy aspects of analysis. Calibration outcome of RSD 0.4 to 3.0% and correlation coefficient values greater than 0.999 were observed during the studies. Spiking studies were done to check the accuracy of the analysis and the recovery values ranging from 93 to 110% were observed. Around 90% ionic content of the drug molecule can be characterized using the developed ion chromatographic methods. These methods can be directly applied for the routine analysis of drug in the pharmaceutical industries.

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