Association between steroid use and nephropathy in patients who were administered a proton pump inhibitor: Analysis of the Japanese Adverse Event Report database

2021 ◽  
Author(s):  
Satoru Mitsuboshi ◽  
Ryohei Kaseda ◽  
Ichiei Narita
Keyword(s):  
Adverse Event ◽  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Adverse Event Report ◽  
Event Report ◽  
Steroid Use ◽  
Inhibitor Analysis

scholarly journals Hepatotoxicity-Related Adverse Effects of Proton Pump Inhibitors: A Cross-Sectional Study of Signal Mining and Analysis of the FDA Adverse Event Report System Database

2021 ◽  
Vol 8 ◽  
Author(s):  
Yifan Zeng ◽  
Ying Dai ◽  
Ziye Zhou ◽  
Xuben Yu ◽  
Dawei Shi
Keyword(s):  
Adverse Event ◽  
Adverse Effects ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Case Reports ◽  
Adverse Event Reporting System ◽  
Adverse Event Report ◽  
Event Report ◽  
Hepatocellular Injury ◽  
Suspect Drug

Background and Objectives: Mounting evidence demonstrates that proton pump inhibitors (PPIs) are associated with a number of adverse effects. However, the literatures about hepatotoxicity-related adverse effects (HRAEs) of PPIs are mostly case reports and a few clinical studies.Methods: We evaluated the association between PPIs and HAREs using the reporting odd ratio (ROR) for mining the adverse event report signals in the FDA Adverse Event Reporting System (FAERS) database.Results: There were 23,825 reports of PPIs as primary suspect drug or second suspect drug, of which 3,253 reports were HRAEs. The top five HRAE signals caused by PPIs were hepatitis cholestatic, cholestasis, fulminant hepatitis, subacute hepatic failure, and acute hepatitis. We also summarized the signals of the HRAEs caused by each PPI. The simultaneous signals were cholestasis and hepatitis cholestatic. For the cholestasis signal, esomeprazole showed an ROR of 21.556 (95% CI 17.592–26.413); pantoprazole showed the highest ROR of 22.611 (95% CI 17.794–28.733) in the hepatic cholestatic signal; lansoprazole was the only PPI with expression in the coma hepatic signal, with an ROR of 10.424 (95% CI 3.340–32.532). By analyzing the reports of pantoprazole-induced hepatic encephalopathy, we found that patients aged over 65 years and males reported the highest rate. And from the combination of drugs and indications of drugs, no significant results were obtained.Conclusions: The RORs of signals of “cholestasis” were generally higher than those of “hepatocellular injury.” And the signals about “cholestasis” in HRAE caused by PPIs are more reported.

Adverse Event Reporting for Proton Pump Inhibitor Therapy

2016 ◽  
Vol 155 (4) ◽  
pp. 547-554 ◽  
Author(s):  
Jason Abramowitz ◽  
Punam Thakkar ◽  
Arton Isa ◽  
Alan Truong ◽  
Connie Park ◽  
...  
Keyword(s):  
Adverse Event ◽  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Proton Pump Inhibitor Therapy ◽  
Adverse Event Reporting ◽  
Inhibitor Therapy ◽  
Event Reporting

scholarly journals Drug target prediction using adverse event report systems: a pharmacogenomic approach

2012 ◽  
Vol 28 (18) ◽  
pp. i611-i618 ◽  
Author(s):  
M. Takarabe ◽  
M. Kotera ◽  
Y. Nishimura ◽  
S. Goto ◽  
Y. Yamanishi
Keyword(s):  
Adverse Event ◽  
Drug Target ◽  
Target Prediction ◽  
Adverse Event Report ◽  
Event Report ◽  
Drug Target Prediction
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