Population Pharmacokinetics and Exposure‐Response Modeling Analyses of Ustekinumab in Adults With Moderately to Severely Active Ulcerative Colitis

Yan Xu; Chuanpu Hu; Yang Chen; Xin Miao; Omoniyi J. Adedokun; Zhenhua Xu; Amarnath Sharma; Honghui Zhou

doi:10.1002/jcph.1582

Population Pharmacokinetics and Exposure‐Response Modeling Analyses of Ustekinumab in Adults With Moderately to Severely Active Ulcerative Colitis

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1582 ◽

2020 ◽

Vol 60 (7) ◽

pp. 889-902

Author(s):

Yan Xu ◽

Chuanpu Hu ◽

Yang Chen ◽

Xin Miao ◽

Omoniyi J. Adedokun ◽

...

Keyword(s):

Ulcerative Colitis ◽

Population Pharmacokinetics ◽

Active Ulcerative Colitis ◽

Exposure Response ◽

Response Modeling

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Population Pharmacokinetics and Exposure–Response Modeling of Golimumab in Adults With Moderately to Severely Active Ulcerative Colitis

Clinical Therapeutics ◽

10.1016/j.clinthera.2019.11.010 ◽

2020 ◽

Vol 42 (1) ◽

pp. 157-174.e4 ◽

Cited By ~ 1

Author(s):

Omoniyi J. Adedokun ◽

Zhenhua Xu ◽

Sam Liao ◽

Richard Strauss ◽

Walter Reinisch ◽

...

Keyword(s):

Ulcerative Colitis ◽

Population Pharmacokinetics ◽

Active Ulcerative Colitis ◽

Exposure Response ◽

Response Modeling

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Population Pharmacokinetics and Exposure‐Response Modeling Analyses of Golimumab in Children With Moderately to Severely Active Ulcerative Colitis

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1353 ◽

2018 ◽

Cited By ~ 3

Author(s):

Yan Xu ◽

Omoniyi J. Adedokun ◽

Daphne Chan ◽

Chuanpu Hu ◽

Zhenhua Xu ◽

...

Keyword(s):

Ulcerative Colitis ◽

Population Pharmacokinetics ◽

Active Ulcerative Colitis ◽

Exposure Response ◽

Response Modeling

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Pharmacokinetics and Exposure-response Relationship of Golimumab in Patients with Moderately-to-severely Active Ulcerative Colitis: Results from Phase 2/3 PURSUIT Induction and Maintenance Studies

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjw141 ◽

2016 ◽

Vol 11 (1) ◽

pp. 1-2 ◽

Cited By ~ 3

Author(s):

Iris Detrez ◽

Ann Gils

Keyword(s):

Ulcerative Colitis ◽

Active Ulcerative Colitis ◽

Phase 2 ◽

Response Relationship ◽

Exposure Response ◽

Relationship Of

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Modeling near-continuous clinical endpoint as categorical: application to longitudinal exposure–response modeling of Mayo scores for golimumab in patients with ulcerative colitis

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-018-9610-0 ◽

2018 ◽

Vol 45 (6) ◽

pp. 803-816 ◽

Cited By ~ 6

Author(s):

Chuanpu Hu ◽

Omoniyi J. Adedokun ◽

Liping Zhang ◽

Amarnath Sharma ◽

Honghui Zhou

Keyword(s):

Ulcerative Colitis ◽

Clinical Endpoint ◽

Exposure Response ◽

Response Modeling

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Population Pharmacokinetics and Exposure‐Response Modeling of Daratumumab Subcutaneous Administration in Patients With Light‐chain Amyloidosis

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1994 ◽

2021 ◽

Author(s):

Man (Melody) Luo ◽

Peijuan (Penny) Zhu ◽

Ivo Nnane ◽

Yuan Xiong ◽

Giampaolo Merlini ◽

...

Keyword(s):

Population Pharmacokinetics ◽

Light Chain ◽

Subcutaneous Administration ◽

Light Chain Amyloidosis ◽

Exposure Response ◽

Response Modeling

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Population pharmacokinetics and exposure–response modeling and simulation for evolocumab in healthy volunteers and patients with hypercholesterolemia

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-018-9592-y ◽

2018 ◽

Vol 45 (3) ◽

pp. 505-522 ◽

Cited By ~ 1

Author(s):

Mita Kuchimanchi ◽

Anita Grover ◽

Maurice G. Emery ◽

Ransi Somaratne ◽

Scott M. Wasserman ◽

...

Keyword(s):

Modeling And Simulation ◽

Healthy Volunteers ◽

Population Pharmacokinetics ◽

Exposure Response ◽

Response Modeling

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Etrolizumab Population Pharmacokinetics (Pop PK) and Covariate Analysis in Patients With Moderately to Severely Active Ulcerative Colitis (UC)

The American Journal of Gastroenterology ◽

10.14309/00000434-201410002-01673 ◽

2014 ◽

Vol 109 ◽

pp. S496 ◽

Cited By ~ 1

Author(s):

Xiaohui (Tracey) Wei ◽

Diana Luca ◽

Yehong Wang ◽

Sharon O’Byrne ◽

Rich Erickson ◽

...

Keyword(s):

Ulcerative Colitis ◽

Population Pharmacokinetics ◽

Active Ulcerative Colitis ◽

Covariate Analysis

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Pharmacokinetics and Exposure-response Relationship of Golimumab in Patients with Moderately-to-Severely Active Ulcerative Colitis: Results from Phase 2/3 PURSUIT Induction and Maintenance Studies

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjw133 ◽

2016 ◽

Vol 11 (1) ◽

pp. 35-46 ◽

Cited By ~ 64

Author(s):

Omoniyi J. Adedokun ◽

Zhenhua Xu ◽

Colleen W. Marano ◽

Richard Strauss ◽

Hongyan Zhang ◽

...

Keyword(s):

Ulcerative Colitis ◽

Active Ulcerative Colitis ◽

Phase 2 ◽

Response Relationship ◽

Exposure Response ◽

Relationship Of

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Brivaracetam Population Pharmacokinetics and Exposure-Response Modeling in Adult Subjects With Partial-Onset Seizures

The Journal of Clinical Pharmacology ◽

10.1002/jcph.761 ◽

2016 ◽

Vol 56 (12) ◽

pp. 1591-1602 ◽

Cited By ~ 22

Author(s):

Rik Schoemaker ◽

Janet R. Wade ◽

Armel Stockis

Keyword(s):

Population Pharmacokinetics ◽

Exposure Response ◽

Response Modeling

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DOP041. Etrolizumab population pharmacokinetics (Pop PK) and covariate analysis in patients with moderately to severely active ulcerative colitis (UC)

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jju027.069 ◽

2015 ◽

Vol 9 (suppl 1) ◽

pp. S46-S47

Keyword(s):

Ulcerative Colitis ◽

Population Pharmacokinetics ◽

Active Ulcerative Colitis ◽

Covariate Analysis

Download Full-text