Incorporation of Gene‐Environment Interaction Terms Improved the Predictive Accuracy of Tacrolimus Stable Dose Algorithms in Chinese Adult Renal Transplant Recipients

2019 ◽  
Vol 59 (6) ◽  
pp. 890-899 ◽  
Author(s):  
Jie Tang ◽  
Jing Xu ◽  
Yue‐Li Zhang ◽  
Rong Liu ◽  
Mou‐Ze Liu ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Predictive Accuracy ◽  
Environment Interaction ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Stable Dose ◽  
Gene Environment Interaction ◽  
Interaction Terms ◽  
Chinese Adult ◽  
Gene Environment

Effects of CYP3A4 and CYP3A5 polymorphisms on tacrolimus pharmacokinetics in Chinese adult renal transplant recipients

2013 ◽  
Vol 23 (5) ◽  
pp. 251-261 ◽  
Author(s):  
Xiao-cong Zuo ◽  
Chee M. Ng ◽  
Jeffrey S. Barrett ◽  
Ai-jing Luo ◽  
Bi-kui Zhang ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Chinese Adult ◽  
Tacrolimus Pharmacokinetics

Evidence for the Scarr–Rowe Effect on Genetic Expressivity in the Health and Retirement Study

2021 ◽  
pp. 1-6
Author(s):  
Michael A. Woodley of Menie ◽  
Mateo Peñaherrera-Aguirre ◽  
Curtis S. Dunkel ◽  
Matthew A. Sarraf
Keyword(s):  
Educational Attainment ◽  
Cognitive Ability ◽  
Low Socioeconomic Status ◽  
Environment Interaction ◽  
Low Socioeconomic ◽  
Gene Environment Interaction ◽  
Interaction Terms ◽  
Gene Environment ◽  
Parental Educational Attainment ◽  
Retirement Study

Abstract The Scarr–Rowe effect is a gene × environment interaction, which is characterized by a negative association between exposure to low socioeconomic status (SES) environments and the additive heritability of cognitive ability. Utilizing a polygenic score for educational attainment (EA3), it was found that the two-way interaction between EA3 and parental educational attainment (EA; used as a proxy for parental SES) was a significant positive predictor of participants’ composite cognitive ability (IQ) score (β = .018, SE = .008, p = .028) after controlling hierarchically for the direct effects of (population-stratification-controlled) EA3, parental EA, and 20 distinct interaction terms (10 involving the interactions between the principal components [PCs] and EA3, and 10 involving the interaction between the PCs and parental EA). The presence of this interaction is consistent with the Scarr–Rowe effect, as the expressivity of EA3 on cognitive ability increases with increasing parental EA. No statistically significant sex differences in the effect magnitudes were found, although the effect was significantly present in the female but not male sample.

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