scholarly journals Do Children Have the Same Vulnerability to Metabolic Drug-Drug Interactions as Adults? A Critical Analysis of the Literature

2013 ◽  
Vol 53 (5) ◽  
pp. 559-566 ◽  
Author(s):  
Farzaneh Salem ◽  
Amin Rostami-Hodjegan ◽  
Trevor N. Johnson
Keyword(s):  
Drug Interactions ◽  
Critical Analysis ◽  
Metabolic Drug

A sensitive HPLC-FL method to simultaneously determine febuxostat and diclofenac in rat plasma: assessment of metabolic drug interactions in vitro and in vivo

2020 ◽  
Vol 12 (16) ◽  
pp. 2166-2175 ◽  
Author(s):  
Dong-Gyun Han ◽  
Kyu-Sang Kim ◽  
Seong-Wook Seo ◽  
Young Mee Baek ◽  
Yunjin Jung ◽  
...  
Keyword(s):  
Sample Preparation ◽  
Drug Interactions ◽  
Simultaneous Determination ◽  
Small Volume ◽  
Rat Plasma ◽  
Metabolic Drug ◽  
Simple Sample Preparation

We developed a sensitive, simple and validated HPLC-FL method for simultaneous determination of FEB and DIC in rat plasma. The method requires a relatively small volume of sample, has simple sample preparation and excellent sensitivity.

Critical Analysis of the Content and Enforcement of Mandatory Consultation and Patient Profile Laws

1992 ◽  
Vol 26 (9) ◽  
pp. 1149-1155 ◽  
Author(s):  
Michael B. Nichol ◽  
Lucy W. Michael
Keyword(s):  
Drug Interactions ◽  
Adverse Drug Reactions ◽  
Critical Analysis ◽  
Drug Information ◽  
Data Sources ◽  
Drug Reactions ◽  
Comprehensive List ◽  
Telephone Interviews ◽  
Patient Profile ◽  
Standard Of Practice

OBJECTIVE: This study evaluates the experience of 12 states that mandate that pharmacists provide consult services to patients and maintain drug profiles. DATA SOURCES: An analysis of each state's statutes and regulations was complemented by telephone interviews of state licensing board staff. RESULTS: Nine states specify the information to be provided during consultations, but only one (Florida) requires a comprehensive list of drug information, including adverse drug reactions, drug—drug interactions, directions for use, and necessary warnings. Eleven of the 12 states also require pharmacists to maintain patient drug profiles, but only 6 states specify the type of information to be included in profiles. State efforts to inform consumers about the pharmacist consultation requirement are limited, with only 7 states undertaking minimal promotional programs. The fact that no states reported any consumer consultation complaints or disciplinary actions against pharmacists for failure to consult illustrates the limited nature of mandatory consultation statutes and regulations. CONCLUSIONS: The wide variety of requirements demonstrates that these laws do not represent a uniform standard of practice. The lack of documented evidence regarding implementation invites questions regarding their usefulness and reinforces the need for enhanced monitoring activities.

Pharmacokinetics and Metabolic Drug Interactions

2006 ◽  
Vol 1 (1) ◽  
pp. 5-20 ◽  
Author(s):  
Sorin Leucuta ◽  
Laurian Vlase
Keyword(s):  
Drug Interactions ◽  
Metabolic Drug

FDA Evaluations Using In Vitro Metabolism to Predict and Interpret In Vivo Metabolic Drug-Drug Interactions: Impact on Labeling

1999 ◽  
Vol 39 (9) ◽  
pp. 899-910 ◽  
Author(s):  
Barbara Davit ◽  
Kellie Reynolds ◽  
Rae Yuan ◽  
Funmilayo Ajayi ◽  
Dale Conner ◽  
...  
Keyword(s):  
Drug Interactions ◽  
In Vitro Metabolism ◽  
Metabolic Drug
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