Reply to: Letter to the Editor “Impact of the CYP2C19*17 Polymorphism on the Pharmacokinetics and Pharmacodynamics of Proton Pump Inhibitors”

2013 ◽  
Vol 53 (3) ◽  
pp. 360-360
Author(s):  
Fen Jiang ◽  
Jae-Gook Shin
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Letter To The Editor

Effects of Proton Pump Inhibitors on Metformin Pharmacokinetics and Pharmacodynamics

2014 ◽  
Vol 42 (7) ◽  
pp. 1174-1179 ◽  
Author(s):  
AnHye Kim ◽  
Inbum Chung ◽  
Seo Hyun Yoon ◽  
Kyung-Sang Yu ◽  
Kyoung Soo Lim ◽  
...  
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Pharmacokinetics And Pharmacodynamics

Effects of genetic polymorphisms on the pharmacokinetics and pharmacodynamics of proton pump inhibitors

2020 ◽  
Vol 152 ◽  
pp. 104606 ◽  
Author(s):  
He-Jian Zhang ◽  
Xue-Hui Zhang ◽  
Jie Liu ◽  
Lu-Ning Sun ◽  
Yi-Wen Shen ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Pharmacokinetics And Pharmacodynamics

scholarly journals Effect of Food and Dosing Regimen on Safety and Efficacy of Proton Pump Inhibitors Therapy—A Literature Review

2021 ◽  
Vol 18 (7) ◽  
pp. 3527
Author(s):  
Agnieszka Wiesner ◽  
Małgorzata Zwolińska-Wcisło ◽  
Paweł Paśko
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Gastric Acidity ◽  
Healthcare Professionals ◽  
Dosing Regimen ◽  
Pharmacokinetics And Pharmacodynamics ◽  
First Choice ◽  
Influence Of Food ◽  
Effect Of Food ◽  
Compliance To Treatment

Proton pump inhibitors (PPIs) are the first-choice drugs used to prevent and treat acid-related diseases. However, a lack of satisfactory response to the standard PPI dose (“PPI failure”) is often reported, especially in patients with gastroesophageal reflux disease. Poor compliance seems to be one of the main causes of PPI failure; hence, it is crucial to gain knowledge on how to properly administer PPIs. In this review, we aimed to evaluate the effect of food, beverages, and dosing regimen on pharmacokinetics and pharmacodynamics of PPIs and to frame recommendations for healthcare professionals to improve both patient’s counseling and compliance to treatment with PPIs. A total of 201 papers were identified following a literature search. After full-text evaluation, 64 studies were included in the review. Co-administration of PPIs with a meal may affect both their bioavailability and effectiveness; however, the influence of food depends on the type of drug and its formulation. Except for pantoprazole, PPIs can be administered in the morning or evening; however, morning intake generally provides better daytime control of gastric acidity. In most cases, the choice of the proper schedule of administration should be based on the patient’s symptoms and individual dosing preferences.

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