Impact of SLCO1B1
 Genotype on Pediatric Simvastatin Acid Pharmacokinetics

Jonathan B. Wagner; Susan Abdel-Rahman; Leon Van Haandel; Andrea Gaedigk; Roger Gaedigk; Geetha Raghuveer; Ralph Kauffman; J. Steven Leeder

doi:10.1002/jcph.1080

Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1080 ◽

2018 ◽

Vol 58 (6) ◽

pp. 823-833 ◽

Cited By ~ 16

Author(s):

Jonathan B. Wagner ◽

Susan Abdel-Rahman ◽

Leon Van Haandel ◽

Andrea Gaedigk ◽

Roger Gaedigk ◽

...

Keyword(s):

Simvastatin Acid

Download Full-text

Development and Validation of an LC–MS-MS Method for the Simultaneous Determination of Simvastatin, Simvastatin Acid and Ezetimibe in Human Plasma and Its Application to Pharmacokinetic Study in the Indian Population

Journal of Chromatographic Science ◽

10.1093/chromsci/bmw043 ◽

2016 ◽

Vol 54 (6) ◽

pp. 985-996 ◽

Cited By ~ 5

Author(s):

Sathish Babu Munaga ◽

Rajani Kumar Valluru ◽

Phani Bhushana Reddy Bonga ◽

V. Sumathi Rao ◽

Hemanth Kumar Sharma

Keyword(s):

Simultaneous Determination ◽

Human Plasma ◽

Pharmacokinetic Study ◽

Indian Population ◽

Simvastatin Acid ◽

Development And Validation

Download Full-text

Bioerodible devices for intermittent release of simvastatin acid

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2007.03.007 ◽

2007 ◽

Vol 340 (1-2) ◽

pp. 6-12 ◽

Cited By ~ 32

Author(s):

J JEON ◽

M THOMAS ◽

D PULEO

Keyword(s):

Simvastatin Acid

Download Full-text

High-throughput salting-out assisted liquid/liquid extraction with acetonitrile for the simultaneous determination of simvastatin and simvastatin acid in human plasma with liquid chromatography

Analytica Chimica Acta ◽

10.1016/j.aca.2009.12.023 ◽

2010 ◽

Vol 661 (2) ◽

pp. 167-172 ◽

Cited By ~ 58

Author(s):

Jun Zhang ◽

Ramona Rodila ◽

Eric Gage ◽

Mathew Hautman ◽

Leimin Fan ◽

...

Keyword(s):

Liquid Chromatography ◽

Simultaneous Determination ◽

Human Plasma ◽

High Throughput ◽

Liquid Extraction ◽

Salting Out ◽

Liquid Liquid Extraction ◽

Simvastatin Acid

Download Full-text

Simultaneous determination of simvastatin and simvastatin acid in human plasma by LC-MS/MS without polarity switch: Application to a bioequivalence study

Journal of Separation Science ◽

10.1002/jssc.200700367 ◽

2008 ◽

Vol 31 (2) ◽

pp. 301-313 ◽

Cited By ~ 19

Author(s):

Bhavin N. Patel ◽

Naveen Sharma ◽

Mallika Sanyal ◽

Pranav S. Shrivastav

Keyword(s):

Simultaneous Determination ◽

Human Plasma ◽

Bioequivalence Study ◽

Simvastatin Acid ◽

Polarity Switch

Download Full-text

Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach

Pharmaceutical Research ◽

10.1007/s11095-014-1581-2 ◽

2014 ◽

Vol 32 (6) ◽

pp. 1864-1883 ◽

Cited By ~ 37

Author(s):

Nikolaos Tsamandouras ◽

Gemma Dickinson ◽

Yingying Guo ◽

Stephen Hall ◽

Amin Rostami-Hodjegan ◽

...

Keyword(s):

Active Metabolite ◽

Pharmacokinetic Model ◽

Simvastatin Acid

Download Full-text

Oxygen plasma surface modification enhances immobilization of simvastatin acid

Biomedical Research ◽

10.2220/biomedres.27.29 ◽

2006 ◽

Vol 27 (1) ◽

pp. 29-36 ◽

Cited By ~ 32

Author(s):

Masao YOSHINARI ◽

Tohru HAYAKAWA ◽

Kenichi MATSUZAKA ◽

Takashi INOUE ◽

Yutaka ODA ◽

...

Keyword(s):

Surface Modification ◽

Oxygen Plasma ◽

Plasma Surface Modification ◽

Plasma Surface ◽

Simvastatin Acid

Download Full-text

Development of a validated liquid chromatography-tandem mass spectrometry assay for the quantification of simvastatin acid, the active metabolite of simvastatin, in human plasma

Translational and Clinical Pharmacology ◽

10.12793/tcp.2016.24.1.22 ◽

2016 ◽

Vol 24 (1) ◽

pp. 22

Author(s):

Hyun-Jung Park ◽

Ae-Kyung Hwang ◽

A-Reum Kim ◽

Soo-Hyeon Kim ◽

Eun-Hwa Kim ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Human Plasma ◽

Active Metabolite ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Simvastatin Acid ◽

Liquid Chromatography Tandem Mass ◽

Mass Spectrometry Assay

Download Full-text

Identification of the Effect of Multiple Polymorphisms on the Pharmacokinetics of Simvastatin and Simvastatin Acid Using a Population-Modeling Approach

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.2014.55 ◽

2014 ◽

Vol 96 (1) ◽

pp. 90-100 ◽

Cited By ~ 31

Author(s):

N Tsamandouras ◽

G Dickinson ◽

Y Guo ◽

S Hall ◽

A Rostami-Hodjegan ◽

...

Keyword(s):

Population Modeling ◽

Modeling Approach ◽

Simvastatin Acid

Download Full-text

Simultaneous Quantification of Simvastatin and Simvastatin Acid in Human Plasma with a Highly Sensitive LC-ESI-MS/MS Method: Application to a Pharmacokinetic Study in Healthy Chinese Volunteers with a Fixed Dose of Simvastatin and Extended-Release Niacin Combination Tablet

Current Pharmaceutical Analysis ◽

10.2174/1573412911666150630182218 ◽

2016 ◽

Vol 12 (2) ◽

pp. 96-106 ◽

Cited By ~ 3

Author(s):

Qiuying Li ◽

Yan Yang ◽

Guobing Shi ◽

Jie Zhang ◽

Guoqing Li ◽

...

Keyword(s):

Human Plasma ◽

Pharmacokinetic Study ◽

Extended Release ◽

Fixed Dose ◽

Combination Tablet ◽

Esi Ms ◽

Simultaneous Quantification ◽

Simvastatin Acid ◽

Highly Sensitive ◽

Healthy Chinese

Download Full-text

Individual and Combined Associations of Genetic Variants in CYP3A4, CYP3A5, and SLCO1B1 With Simvastatin and Simvastatin Acid Plasma Concentrations

Journal of Cardiovascular Pharmacology ◽

10.1097/fjc.0000000000000246 ◽

2015 ◽

Vol 66 (1) ◽

pp. 80-85 ◽

Cited By ~ 13

Author(s):

Jasmine A. Luzum ◽

Elizabeth Theusch ◽

Kent D. Taylor ◽

Ann Wang ◽

Wolfgang Sadee ◽

...

Keyword(s):

Genetic Variants ◽

Plasma Concentrations ◽

Simvastatin Acid

Download Full-text