Novel involvement of PLD–PKCδ–CREB axis in regulating FGF‐2‐mediated pentraxin 3 production in human nasal fibroblast cells

2021 ◽  
Author(s):  
Yih‐Jeng Tsai ◽  
Ming‐Chieh Ma ◽  
Pi‐Hui Wu ◽  
Wen‐Bin Wu
Keyword(s):  
Fibroblast Cells ◽  
Pentraxin 3

scholarly journals Liver X Receptor Expression and Pentraxin 3 Production in Chronic Rhinosinusitis and Sinonasal Mucosal Fibroblast Cells

2021 ◽  
Vol 10 (3) ◽  
pp. 452
Author(s):  
Yih-Jeng Tsai ◽  
Ping-Hung Shen ◽  
Sheng-Dean Luo ◽  
Wen-Bin Wu
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Mucosa ◽  
Cholesterol Metabolism ◽  
Receptor Expression ◽  
Peroxisome Proliferator ◽  
Fibroblast Cells ◽  
Pentraxin 3 ◽  
Peroxisome Proliferator Activated Receptor ◽  
Phosphoinositide 3 Kinase ◽  
Sinonasal Mucosa

The long pentraxin 3 (PTX3) is a prototypic molecule for recognizing pathogens. Liver X receptors (LXRs), belonging to nuclear receptors (NRs) for cholesterol metabolism through heterodimerizing with other NRs, were recently reported to participate in inflammation. However, their roles in chronic rhinosinusitis without nasal polyps (CRSsNP) are unclear. Therefore, this study was sought to explore roles of LXRs in chronic rhinosinusitis (CRS) sinonasal tissues and derived fibroblasts. Immunohistochemistry indicated that LXRα and β expression and lipid/fat deposition were differentially expressed in the control and CRSsNP nasal mucosa. GW7647 (a peroxisome proliferator activated receptor α (PPARα) agonist) and GW3965 (a dual agonist for LXRα and β) significantly caused PTX3 induction in the fibroblast cells. GW3965 induced PTX3 mRNA and protein expression, and the induction substantially led to PTX3 secretion. Meanwhile, an endogenous agonist-cholesterol had a similar enhancing effect on the induction of PTX3 protein. LXR siRNA knockdown to lower LXRα or β expression significantly compromised PTX3 induction. Interestingly, GW3965 also induced phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) activation and its inhibition reduced PTX3 expression. Collectively, we demonstrated here for the first time that CRSsNP nasal mucosa differentially expresses LXRα and β and deposits lipids/fats that may contain cholesterol metabolites to activate LXRs. Activation of LXRs leads to PTX3 production in sinonasal mucosa-derived fibroblasts. Our previous study showed PTX3 overexpression in the nasal cavity of CRSsNP, whereas this study highlights that cholesterol metabolites and LXR activation regulate PTX3 production and may contribute to antimicrobial activity and tissue repair during CRSsNP progression.

Pentraxin 3: A novel biomarker for Heart failure?

2008 ◽  
Vol 7 ◽  
pp. 42-42
Author(s):  
S ABOURAYA ◽  
A ABOURAYA ◽  
M HELMII
Keyword(s):  
Heart Failure ◽  
Pentraxin 3

Statins Pentraxin 3 and Heart Failure: What is the link?

2008 ◽  
Vol 7 ◽  
pp. 187-187
Author(s):  
A ABOURAYA ◽  
S ABOURAYA ◽  
M HELMII
Keyword(s):  
Heart Failure ◽  
Pentraxin 3

Pentraxin-3 as a more sensitive marker of coronary artery disease severity than C-reactive protein

2013 ◽  
Author(s):  
Janusz Szkodzinski ◽  
Bartosz Hudzik ◽  
Aleksander Danikiewicz ◽  
Anna Pietka-Rzycka ◽  
Andrzej Lekston ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Disease Severity ◽  
Pentraxin 3 ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Coronary Artery Disease Severity ◽  
Artery Disease ◽  
Sensitive Marker

Susceptibility of Intracellular Coxiella burnetii to Antimicrobial Peptides in Mouse Fibroblast Cells

2013 ◽  
Vol 21 (2) ◽  
pp. 115-123 ◽  
Author(s):  
Nathan Unsworth ◽  
Raymond Dawson ◽  
John Wade ◽  
Chun-Qiang Liu
Keyword(s):  
Antimicrobial Peptides ◽  
Coxiella Burnetii ◽  
Mouse Fibroblast ◽  
Fibroblast Cells
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